Pair bonding: is it all in the brain? This project aims to understand the interaction between classic pair bonding neural circuits, parasites, and the immune system in sleepy lizards. Social bonds are a cornerstone of human societies, especially true of the pair bond and this project expects to generate knowledge to help understand why healthy adult pair bonds are the single best predictor of longevity in humans. The expected outcomes of this project are to reveal the mechanistic basis of pair b ....Pair bonding: is it all in the brain? This project aims to understand the interaction between classic pair bonding neural circuits, parasites, and the immune system in sleepy lizards. Social bonds are a cornerstone of human societies, especially true of the pair bond and this project expects to generate knowledge to help understand why healthy adult pair bonds are the single best predictor of longevity in humans. The expected outcomes of this project are to reveal the mechanistic basis of pair bonding by identifying the brain regions, cell types and neurochemicals that promote pair bonding behaviour — for the first time in a wild animal. This project should provide significant benefits by increasing our knowledge of how pair bonds promote wellness.Read moreRead less
Coevolution of sundew bugs and sundews. This project aims to conduct a study of insect-plant interactions to determine if insects and plants coevolve or if they diversify by other evolutionary processes. Insect-plant coevolution is a hotly contested field in evolutionary biology. In Australia, a remarkable interaction exists between carnivorous plants and a group of bugs that steal the plant’s prey. This system offers a great opportunity to test competing coevolutionary theories through a combin ....Coevolution of sundew bugs and sundews. This project aims to conduct a study of insect-plant interactions to determine if insects and plants coevolve or if they diversify by other evolutionary processes. Insect-plant coevolution is a hotly contested field in evolutionary biology. In Australia, a remarkable interaction exists between carnivorous plants and a group of bugs that steal the plant’s prey. This system offers a great opportunity to test competing coevolutionary theories through a combination of historical and ecological approaches. The project expects to showcase the evolution and uniqueness of Australia’s native biota.Read moreRead less
Can parasites cause host population divergence? . Parasites have been proposed to be drivers of population divergence, and ultimately speciation, yet the dynamics of this process are not well understood. This project will utilise new genomic techniques, novel hybrid zone analyses, and data on mate choice, to investigate the hypothesis that parasites drive population divergence through an interaction with immune response genes in the sleepy lizard Tiliqua rugosa. This species provides an unpreced ....Can parasites cause host population divergence? . Parasites have been proposed to be drivers of population divergence, and ultimately speciation, yet the dynamics of this process are not well understood. This project will utilise new genomic techniques, novel hybrid zone analyses, and data on mate choice, to investigate the hypothesis that parasites drive population divergence through an interaction with immune response genes in the sleepy lizard Tiliqua rugosa. This species provides an unprecedented system, backed by 37 years of long term host-parasite and behavioural data, and recent genetic analyses. This project intends to produce significant data to allow an examination of the early stages of host-parasite evolution in action, providing novel insights into the speciation process. Read moreRead less
A new history of law in post-revolutionary England (c.1689-1760). This project seeks to recover and reassess the general history of English law during the seven decades following the Glorious Revolution of 1688–89, when limited monarchy, parliamentary government and the rule of law became new constitutional norms for an emergent imperial British state (and, eventually, for Australia). It aims to chart the modes of law and governance variously experienced, created and used by lay men and women, h ....A new history of law in post-revolutionary England (c.1689-1760). This project seeks to recover and reassess the general history of English law during the seven decades following the Glorious Revolution of 1688–89, when limited monarchy, parliamentary government and the rule of law became new constitutional norms for an emergent imperial British state (and, eventually, for Australia). It aims to chart the modes of law and governance variously experienced, created and used by lay men and women, husbands, wives and children, as well as by judges, lawyers, legislators and ministers. The results of this conceptual investigation, which aims to re-interpret the history of English law and government in the broadest possible way, is planned to appear as Volume IX in the Oxford History of the Laws of England series.Read moreRead less
How do protein quality control mechanisms maintain neuronal ageing? This project aims to interrogate how mechanisms of protein quality control act in the brain - an organ that is particularly vulnerable to a high load of misfolded protein - to maintain normal physiology during ageing. This project expects to make advances in cellular biochemistry and neuroscience, using an innovative proximity labelling approach to identify quality control regulators in neurons that specifically engage with misf ....How do protein quality control mechanisms maintain neuronal ageing? This project aims to interrogate how mechanisms of protein quality control act in the brain - an organ that is particularly vulnerable to a high load of misfolded protein - to maintain normal physiology during ageing. This project expects to make advances in cellular biochemistry and neuroscience, using an innovative proximity labelling approach to identify quality control regulators in neurons that specifically engage with misfolded proteins during ageing, within the nervous system of a living animal. Expected outcomes of this project will generate new knowledge of brain physiology and ageing relevant to all animals. This should provide significant benefits, such as a greater understanding of long-term brain functions including memory.Read moreRead less
Indigenous foodways in colonial Cape York Peninsula. This project aims to trace historical Indigenous foodways in colonial Cape York Peninsula, Queensland, through a program of collaborative community-based archaeological and anthropological research. Food was a key medium for cultural exchanges between Indigenous peoples and settler-colonists. The analysis of foodways is known to provide unparalleled insights on daily life, as well as the development of both cultural values and social relations ....Indigenous foodways in colonial Cape York Peninsula. This project aims to trace historical Indigenous foodways in colonial Cape York Peninsula, Queensland, through a program of collaborative community-based archaeological and anthropological research. Food was a key medium for cultural exchanges between Indigenous peoples and settler-colonists. The analysis of foodways is known to provide unparalleled insights on daily life, as well as the development of both cultural values and social relationships. This has received limited attention in archaeological investigations in Australia. Results will provide greater insight into the history behind our current society.Read moreRead less
Mechanisms of memory function involving site-specific tau phosphorylation. This project aims to understand the molecular principles that facilitate encoding, maintenance and retrieval of memories in the brain. To store memories in brain circuits, electrical and chemical signals are crucial. Brain cells can integrate signals into biochemical modifications of intracellular proteins. The nature of the protein modifications that represent memory within brain cells is unknown. This project uses innov ....Mechanisms of memory function involving site-specific tau phosphorylation. This project aims to understand the molecular principles that facilitate encoding, maintenance and retrieval of memories in the brain. To store memories in brain circuits, electrical and chemical signals are crucial. Brain cells can integrate signals into biochemical modifications of intracellular proteins. The nature of the protein modifications that represent memory within brain cells is unknown. This project uses innovative genome editing, mathematical modelling and proteomic approaches, to study how biochemical modifications of a key protein called tau help encode and retrieve memories. These molecular insights will make a significant advance in the current understanding of a brain function that is essential to all human activities.Read moreRead less
Molecular control of memory traces. This project aims to understand how particular molecules help encode memories in the brain for future retrieval. Individual memories are encoded in brain cells through an unknown physical process. This project uses innovative approaches to manipulate memory-containing cells and will provide a new detailed explanation of memory. Outcomes of this work will significantly advance the current understanding of how memories are physically generated and maintained, wh ....Molecular control of memory traces. This project aims to understand how particular molecules help encode memories in the brain for future retrieval. Individual memories are encoded in brain cells through an unknown physical process. This project uses innovative approaches to manipulate memory-containing cells and will provide a new detailed explanation of memory. Outcomes of this work will significantly advance the current understanding of how memories are physically generated and maintained, which is an essential component of human and animal life. This research provides significant benefits in understanding the biology behind memory and in maintaining memory capacity in ageing.
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Mobilising Dutch East India Company collections for new global stories . Australia has a rich legacy of archives, art and artefacts, including 4 shipwrecks in WA, from its history of encounters with the Dutch East India Company (VOC). Through comparative research in Australian and overseas museums and archives we aim to situate Australian collections in a global context, creating new stories about Australia as part of the VOC global network. An interdisciplinary team will train 3 ECRs and 7 HDRs ....Mobilising Dutch East India Company collections for new global stories . Australia has a rich legacy of archives, art and artefacts, including 4 shipwrecks in WA, from its history of encounters with the Dutch East India Company (VOC). Through comparative research in Australian and overseas museums and archives we aim to situate Australian collections in a global context, creating new stories about Australia as part of the VOC global network. An interdisciplinary team will train 3 ECRs and 7 HDRs and forge partnerships with the Netherlands, Britain, Denmark, Germany, Sweden, Indonesia, Malaysia, and South Africa, strengthening national capacity. Our analysis will enrich the value of collections, provide narratives for museums and sites, and revitalise content for international and domestic tourism markets.Read moreRead less
Beyond Empire: Transnational religious networks and liberal cosmopolitanisms. This project aims to study religion as a dimension of international affairs between 1860 and 1950. It will examine the contribution of faith-based activity, networking and thought to global governance and peace building institutionalised in the United Nations, universal human rights and humanitarianism that shaped the second half of the twentieth century. The project will explore the emergence of these faith-based cosm ....Beyond Empire: Transnational religious networks and liberal cosmopolitanisms. This project aims to study religion as a dimension of international affairs between 1860 and 1950. It will examine the contribution of faith-based activity, networking and thought to global governance and peace building institutionalised in the United Nations, universal human rights and humanitarianism that shaped the second half of the twentieth century. The project will explore the emergence of these faith-based cosmopolitanisms at the interstices of multi-faith, multi-cultural and multi-racial webs of connection and their significance for Australian, regional and global history. This could show how secular and inter-faith activisms can produce cosmopolitan visions of practical co-existence.Read moreRead less