Evolutionary history and impact of adeno-associated viruses in Australia. Recently accrued evidence identifies Australia as an ideal closed-model system in which to elucidate the evolutionary history of a group of non-pathogenic viruses, known as adeno-associated viruses (AAVs). This project aims to trace back the evolutionary history of AAVs for tens of millions of years via molecular fossil imprints left behind by ancient viral invasions of Australian marsupial genomes. Concurrently, the poten ....Evolutionary history and impact of adeno-associated viruses in Australia. Recently accrued evidence identifies Australia as an ideal closed-model system in which to elucidate the evolutionary history of a group of non-pathogenic viruses, known as adeno-associated viruses (AAVs). This project aims to trace back the evolutionary history of AAVs for tens of millions of years via molecular fossil imprints left behind by ancient viral invasions of Australian marsupial genomes. Concurrently, the potential impact that these viral invasions had on the evolutionary development of their ancestral hosts will be investigated. This could facilitate previously unattainable insights into both AAV and marsupial evolution, with broader implications relevant to the advancement of the fields of virology and mammalian evolution.Read moreRead less
Contact Networks, Immunity, and Evolution in Competing Cancer Epidemics. The project aims to evaluate evolutionary interactions between two transmissible cancer epidemics affecting Tasmanian devils and quantify their feedback on infection risk and epidemic behaviour. Using contact tracing and a phylogenetic framework we aim to quantify how tumour lineages evolve with each generation of infection and their effects on susceptibility to infection and disease progression. We expect to reveal the hos ....Contact Networks, Immunity, and Evolution in Competing Cancer Epidemics. The project aims to evaluate evolutionary interactions between two transmissible cancer epidemics affecting Tasmanian devils and quantify their feedback on infection risk and epidemic behaviour. Using contact tracing and a phylogenetic framework we aim to quantify how tumour lineages evolve with each generation of infection and their effects on susceptibility to infection and disease progression. We expect to reveal the host immuno-genetic basis underpinning cancer suppression and the adaptive capacity of populations in response to infectious diseases. This should significantly improve our ability to understand and manage this and other epidemic outbreaks in wildlife, as well as advancing our knowledge in cancer ecology and evolution.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE170101116
Funder
Australian Research Council
Funding Amount
$370,159.00
Summary
Adaptations in Tasmanian devil facial tumour disease. This project aims to understand how defence mechanisms against infectious diseases arise and evolve in nature. Infectious diseases exert strong evolutionary pressures on populations, forcing the development of adaptive strategies to fight the costs of infection. The project aims to determine individual differences in response to infection and how these affect population-scale transmission and evolutionary dynamics under natural and managed sc ....Adaptations in Tasmanian devil facial tumour disease. This project aims to understand how defence mechanisms against infectious diseases arise and evolve in nature. Infectious diseases exert strong evolutionary pressures on populations, forcing the development of adaptive strategies to fight the costs of infection. The project aims to determine individual differences in response to infection and how these affect population-scale transmission and evolutionary dynamics under natural and managed scenarios. This is expected to reveal populations’ adaptive capability and resilience against diseases and the effects of management interventions in controlling disease outbreaks and preventing population declines or extinctions.Read moreRead less
Democratization and conflict management in Eastern Indonesia. The proposed project directly addresses the priority goal of understanding our region and the world to safeguard Australia. Indonesia is not only Australia's closest northern neighbour and the world's most populous Muslim nation, but also the third-largest democracy and the strategically most important country in Southeast Asia. The project will greatly enhance our understanding of some of the least known areas of Indonesia and is int ....Democratization and conflict management in Eastern Indonesia. The proposed project directly addresses the priority goal of understanding our region and the world to safeguard Australia. Indonesia is not only Australia's closest northern neighbour and the world's most populous Muslim nation, but also the third-largest democracy and the strategically most important country in Southeast Asia. The project will greatly enhance our understanding of some of the least known areas of Indonesia and is intended to prescribe concrete recommendations for the Australian government and aid organizations to assist them in their endeavours to promote democratization and help prevent and/or resolve communal conflict.Read moreRead less
Globalization and New Wars: The War in Chechnya. Identifying the causes of conflict has practical applications for Australian security policy formulation, since an area of instability exists within our region. A finding that causes of war arise either from complex domestic political struggles, or processes of globalization, has implications for which strategic posture Australia should adopt in responding to crises. The project falls within Research Priority 4: 'Safeguarding Australia'. By addres ....Globalization and New Wars: The War in Chechnya. Identifying the causes of conflict has practical applications for Australian security policy formulation, since an area of instability exists within our region. A finding that causes of war arise either from complex domestic political struggles, or processes of globalization, has implications for which strategic posture Australia should adopt in responding to crises. The project falls within Research Priority 4: 'Safeguarding Australia'. By addressing the need to better understand causes of war, it assists Australian policymakers to better understand and manage potential threats. Greater knowledge of war likewise assists defence policy planners to maintain an operational advantage for Australia's defence forces.Read moreRead less
Australia and the OECD: A Neglected Arena in Multi-level Governance. Issues such as trade liberalisation and the development of international agreements are of considerable importance for domestic policy within Australia. Development of such ideas and policies often serve as the basis for subsequent agreements in the multilateral system through policy transfer or the strategy of ?forum shopping?. Australia's interests as a middle power lie in a rules-based system, and thus its ability to maximiz ....Australia and the OECD: A Neglected Arena in Multi-level Governance. Issues such as trade liberalisation and the development of international agreements are of considerable importance for domestic policy within Australia. Development of such ideas and policies often serve as the basis for subsequent agreements in the multilateral system through policy transfer or the strategy of ?forum shopping?. Australia's interests as a middle power lie in a rules-based system, and thus its ability to maximize its effectiveness in shaping those rules is of paramount importance. This project will contribute knowledge which will serve directly this goal, by enhancing our understanding of the OECD as an arena of multilevel governance and Australia's participation within it.Read moreRead less
Reform in the antipodes: Quaker humanitarians, imperial journeys and early histories of human rights. This study adds an important new chapter to the history of human rights by examining Quaker humanitarian tours to the antipodean colonies of Australia, Mauritius, and the Cape Colony, which led to major imperial reforms in the treatment of slaves, Indigenous peoples, convicts and indentured labourers in the British Empire.
Everyday Obligations: Households and Economic Change in the British Isles 1650-1850. The project will develop scholarship about the history of family and households in the British Isles during industrialisation and associated changes. The resulting published work will advance our knowledge of the social implications of demographic change; the relationship between people and environment; the impact of industrialisation on demography as well as the micro-economies of past households and families. ....Everyday Obligations: Households and Economic Change in the British Isles 1650-1850. The project will develop scholarship about the history of family and households in the British Isles during industrialisation and associated changes. The resulting published work will advance our knowledge of the social implications of demographic change; the relationship between people and environment; the impact of industrialisation on demography as well as the micro-economies of past households and families. An innovative aspect will be the use of Australian historical sources, particularly for Van Diemen's Land, to cast light on the history of Britain before 1850.Read moreRead less
Female Convicts as Women Travellers: an investigation into how the itineraries of convict experience affected life narratives. For convict women sent to Australia, ?transportation? meant international travel. By mapping the convicts as travellers, this project will afford a new perspective on women whose convict itineraries radically affected the direction of their lives. Alert to the specifics of time and place, the project investigates the carceral and non-carceral experiences of women whose s ....Female Convicts as Women Travellers: an investigation into how the itineraries of convict experience affected life narratives. For convict women sent to Australia, ?transportation? meant international travel. By mapping the convicts as travellers, this project will afford a new perspective on women whose convict itineraries radically affected the direction of their lives. Alert to the specifics of time and place, the project investigates the carceral and non-carceral experiences of women whose shared voyage as convicts was neither the beginning nor the end of their travels. The research involves a systematic cluster sampling of three ships which sailed to Van Diemen's Land while transportation was at its height: the Harmony (1829), Atwick (1838), and Elizabeth and Henry (1847). Read moreRead less
Intimacy and Violence in Anglo Pacific Rim settler colonial societies. Violence and intimacy were both fundamental to the formation of settler colonial societies, yet we know surprisingly little of how they were connected. Through a large-scale collaboration of leading scholars, this project aims to produce the first transnational analysis of intimacy and violence as key, intertwined vectors in the development of settler societies across the colonial Anglophone Pacific Rim. Drawing out connectio ....Intimacy and Violence in Anglo Pacific Rim settler colonial societies. Violence and intimacy were both fundamental to the formation of settler colonial societies, yet we know surprisingly little of how they were connected. Through a large-scale collaboration of leading scholars, this project aims to produce the first transnational analysis of intimacy and violence as key, intertwined vectors in the development of settler societies across the colonial Anglophone Pacific Rim. Drawing out connections between the broad-scale dynamics of colonial rule and the violent and intimate domains of its implementation on the ground, the project aims to generate new comparative insights into the development of colonial settler cultures and create enhanced understanding of their legacies for western settler democracies today.Read moreRead less