Arbovirus Activation And Modulation Of NLRP3 Inflammasome
Funder
National Health and Medical Research Council
Funding Amount
$779,720.00
Summary
This project aims to establish how mosquito borne viruses such as Ross River and dengue viruses interacts with the human host to cause disease, including how the virus evades the host’s immune response to persist and cause disease for prolonged periods. Knowing how differences in the virus and the host’s immune system interplay to cause asymptomatic to severely disabling disease will assist in devising new treatments and prevention programs to lessen the impact of these diseases in Australia.
New Insights Into Viral Inflammatory Disease Mechanisms And Approaches To Therapy
Funder
National Health and Medical Research Council
Funding Amount
$631,010.00
Summary
This fellowship aims to establish how viruses cause disease, including how they evade the immune response to persist and cause disease for prolonged periods. My vision is that knowing how the virus and the immune system interact to determine disease severity will assist in devising new treatments and prevention programs to lessen the impact of viral diseases in Australia and worldwide.
Mosquito-borne alphaviruses such as Ross River and chikungunya viruses cause widespread epidemics and exert extreme pressure on the public health systems of affected regions. Alphaviruses spreads to joints and triggers a severe disease in those affected. There are no effective treatments or vaccines. The project will investigate virus-host interaction at the bite site. The outcome will be new knowledge to treat infection at the mosquito bite site to prevent joint disease.
Novel Insights Into The Pathobiology Of Alphavirus Infections
Funder
National Health and Medical Research Council
Funding Amount
$827,660.00
Summary
Infections with mosquito-borne viruses are increasing at an alarming rate worldwide. Ross River virus is endemic in parts of Australia, PNG and Pacific islands, while chikungunya virus is distributed globally and causes recurrent pandemics that involve millions of people. These viruses cause severe musculoskeletal disease for several months after infection. This project aims to establish how these viruses interact with the human host to cause disease and may provide a basis for new treatments.
Glycotherapeutics; A New Class Of Treatment For Alphavirus-induced Musculoskeletal Disease
Funder
National Health and Medical Research Council
Funding Amount
$449,868.00
Summary
The hallmark of alphavirus disease is crippling pain and joint arthritis, which often has an extended duration. Currently there is no licenced specific treatment for alphavirus disease and the increasing spread of infection highlights an urgent need for therapeutic intervention strategies. This grant looks at the potential of pentosan polysulfate as a promising drug-repurposing candidate for the treatment of alphavirus-induced arthritis.
Indigenous peoples, the British Empire, and self-government for the Australian colonies. This study enhances our understanding of the foundations and representative functions of Australian democratic institutions, especially as they concern Indigenous-settler-missionary-imperial relationships. In drawing out the connections between two major questions for Australian history and modern society - democracy and Indigenous dispossession - the project will contribute deeper historical knowledge to cu ....Indigenous peoples, the British Empire, and self-government for the Australian colonies. This study enhances our understanding of the foundations and representative functions of Australian democratic institutions, especially as they concern Indigenous-settler-missionary-imperial relationships. In drawing out the connections between two major questions for Australian history and modern society - democracy and Indigenous dispossession - the project will contribute deeper historical knowledge to current public debate about Indigenous policy past and present. It will also illuminate the importance of understanding Australian history in broad transcolonial and transnational contexts and enhance the contribution of Australian historians to imperial, missionary, and comparative settler-society histories.Read moreRead less
Shipwrecks of the Roaring Forties: a maritime archaeological reassessment of some of Australia's earliest shipwrecks. This project will evaluate new ways of investigating the history of Europeans in the Indian Ocean by using the latest technology to evaluate seven Western Australian shipwrecks excavated over 40 years ago. The project will work with emerging technologies to study these significant sites and collections.
Warriors, Patriots, Traitors and Opportunists: Chinese Women and War. This project furthers our knowledge of the workings of the political, military and security scene in one of our most strategically important neighbours, the PRC. The better we understand the PRC and how it responds in times of military disruption the more likely we are to be able to further Australian interests within this large market and ensure continued national security. The project also enhances Australia's strong reputat ....Warriors, Patriots, Traitors and Opportunists: Chinese Women and War. This project furthers our knowledge of the workings of the political, military and security scene in one of our most strategically important neighbours, the PRC. The better we understand the PRC and how it responds in times of military disruption the more likely we are to be able to further Australian interests within this large market and ensure continued national security. The project also enhances Australia's strong reputation as leaders in scholarship in Chinese Studies by producing research publications of high impact that present new perspectives on old projects. This project will keep Australia at the forefront of research in Chinese Studies.Read moreRead less