Imaging The Hepatitis C Virus Life Cycle In Real-time
Funder
National Health and Medical Research Council
Funding Amount
$477,504.00
Summary
Hepatitis C virus (HCV) is a serious viral pathogen that causes significant liver disease. This proposal plans to examine how two proteins from the HCV, core and NS5A, interact with host proteins and pathways to facilitate viral replication and release of HCV; two processes that are poorly understood. Specifically we will tag viral proteins to allow us to investigate the HCV life cycle in living cells and determine the role of core and NS5A in facilitating HCV replication. This proposal may unco ....Hepatitis C virus (HCV) is a serious viral pathogen that causes significant liver disease. This proposal plans to examine how two proteins from the HCV, core and NS5A, interact with host proteins and pathways to facilitate viral replication and release of HCV; two processes that are poorly understood. Specifically we will tag viral proteins to allow us to investigate the HCV life cycle in living cells and determine the role of core and NS5A in facilitating HCV replication. This proposal may uncover novel therapeutic strategies to combat HCV.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE120102821
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Molecular genetic adaptive processes in natural co-evolution between rabbits and the rabbit haemorrhagic disease virus. This project will use extensive sampling and long-term field data to reveal ongoing co-evolutionary mechanisms behind the increasing resistance of pest Australian wild rabbits against a viral pathogen. The results will increase the understanding of evolutionary mechanisms in nature and will provide basic information for biological pest control of rabbits.
What drives parasite spread through social networks: lessons from lizards. Australia's biodiversity is continually threatened by new epidemics of local and foreign diseases and parasites. This project will enhance our understanding of how these diseases spread, allowing more effective controls to be developed to protect wildlife species, animal populations and, ultimately, Australian ecosystems.
Parasite transmission through social networks in the pygmy bluetongue lizard. Australia's biodiversity is continually threatened by new epidemics of diseases and parasites, some local, others from overseas. This project will provide information on how they spread so that more effective management of these diseases can be developed to protect wildlife species, animal populations and, ultimately, Australian ecosystems.
I am a molecular virologist researching the host response to hepatitis C virus (HCV) infection with the aim of understanding how the liver clears HCV infection. An understanding of this process will hopefully lead to novel antiviral strategies to combat not only HCV but a broad range of other viral infections.
A Pragmatic Randomised Clinical Trial Of Nicotine Vaporisers Added To Smoking Cessation Treatment For Priority Populations Living With Comorbidities
Funder
National Health and Medical Research Council
Funding Amount
$1,499,145.00
Summary
Smoking is a leading cause of early death for people with certain health conditions because they are more likely to smoke and are also at greater risk of tobacco-related disease. This clinical trial will test whether encouraging people living with Hepatitis C Virus, people on opiate substitution therapy and people living with HIV who smoke to use nicotine vaporisers long-term, in addition to current smoking cessation treatments, will help them to stay abstinent from smoking.
Assessing the Role of Political and Regulatory Risks for Foreign Investors: A Multi-Country Study of Four Industry Sectors. This project will benefit Australian enterprise engaged in investment activities in Asia by providing them with the necessary methodological and analytical systems to identify, measure and assess political and regulatory risks to their investment interests. By doing so, the project will increase the investment transparency of Asia's emerging economies and thus the ability ....Assessing the Role of Political and Regulatory Risks for Foreign Investors: A Multi-Country Study of Four Industry Sectors. This project will benefit Australian enterprise engaged in investment activities in Asia by providing them with the necessary methodological and analytical systems to identify, measure and assess political and regulatory risks to their investment interests. By doing so, the project will increase the investment transparency of Asia's emerging economies and thus the ability of Australian enterprise to operate efficiently in institutionally complex and competitive offshore environments. This will benefit Australia's economy by strengthening Australia's national economic security and the safety of Australia's national savings invested in the region.Read moreRead less
Political Risk, Institutions and Regulatory Regimes: Business, Foreign Investment and Public Administration in Asia. Rating accurately the risk environment of emerging economies has always been problematic. Insufficiently developed methodological tools and the lack of institutional and regulatory data make the process imprecise. This project overcomes this problem, developing a new industry based risk assessment system for understanding political risk to commercial activities and foreign investo ....Political Risk, Institutions and Regulatory Regimes: Business, Foreign Investment and Public Administration in Asia. Rating accurately the risk environment of emerging economies has always been problematic. Insufficiently developed methodological tools and the lack of institutional and regulatory data make the process imprecise. This project overcomes this problem, developing a new industry based risk assessment system for understanding political risk to commercial activities and foreign investors in nine of Asia's most rapidly developing economies. The study, one of the first to correlate institutional and regulatory forms to the incidence, severity and recurrence of risk, will deepen our knowledge of political and regulatory institutions in Asia and provide investors with the ability to navigate those environments successfully. Read moreRead less
Predicting Drug-drug Interactions Due To Tyrosine Kinase Inhibitors: Inhibition Of Drug Metabolising Enzymes And Transporters
Funder
National Health and Medical Research Council
Funding Amount
$535,495.00
Summary
Tyrosine kinase inhibitors (TKIs) are a new class of anticancer agents. Cancer patients typically receive multiple drugs, for the treatment of cancer and other diseases, increasing the probability of interactions between coadministered drugs. Despite the widespread use of TKIs, their potential to cause drug interactions is poorly understood. Using novel in vitro approaches, this project will identify drug interactions precipitated by TKIs thereby improving drug efficacy and patient safety.
Shipwrecks of the Roaring Forties: a maritime archaeological reassessment of some of Australia's earliest shipwrecks. This project will evaluate new ways of investigating the history of Europeans in the Indian Ocean by using the latest technology to evaluate seven Western Australian shipwrecks excavated over 40 years ago. The project will work with emerging technologies to study these significant sites and collections.