The Role Of Interferon-regulatory Factors In The Host Defense Against Bacterial Infection
Funder
National Health and Medical Research Council
Funding Amount
$355,711.00
Summary
Type I interferons are used in the treatment of viral infection. However, the therapeutic potential of type I interferons for the treatment of bacterial infection is not known because we do not fully understand their functional roles and regulation in hosts infected with bacteria. My proposal aims to investigate the role of one family of regulatory proteins, known as interferon-regulatory factors, in the host defense against foodborne bacteria.
Characterization Of Novel, Colitis Associated Pathobionts To Identify Therapeutic Targets In The Host Immune Response
Funder
National Health and Medical Research Council
Funding Amount
$684,609.00
Summary
Applying cutting edge methods to grow bacteria from the human gut, we have identified three species, two previously unknown, that are found in many inflammatory diseases including Inflammatory bowel disease, colorectal cancer and in cancer immunotherapy patients who experience colitis. By characterizing these bacteria and the immune response in human cells we are seeking to discover novel targetted methods to prevent colitis and gastrointestinal inflammation.