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IC7: A Gp130 Receptor Ligand To Treat Type 2 Diabetes
Funder
National Health and Medical Research Council
Funding Amount
$598,833.00
Summary
Over the past decade work from our group has identified that a group of proteins, termed gp130 receptor cytokines, can lead to improvements in both causes and symptoms of type 2 diabetes in both animals and humans. Unfortunately, due to side effects, clinical trial using analogues of these proteins have failed. We believe we know why this is the case and we now have developed new, improved peptides that should overcome these side effects. We hope that we have created a novel drug that will help ....Over the past decade work from our group has identified that a group of proteins, termed gp130 receptor cytokines, can lead to improvements in both causes and symptoms of type 2 diabetes in both animals and humans. Unfortunately, due to side effects, clinical trial using analogues of these proteins have failed. We believe we know why this is the case and we now have developed new, improved peptides that should overcome these side effects. We hope that we have created a novel drug that will help treat type 2 diabetes.Read moreRead less
The Role Of Vitamin D In Beta-cell Function And Diabetes
Funder
National Health and Medical Research Council
Funding Amount
$554,248.00
Summary
Vitamin D deficiency is common in Australia, with the success of the 'slip, slop, slap' campaigns. Low levels of Vitamin D have been associated with diabetes. This grant aims to determine how vitamin D affects insulin release and blood glucose levels.
There is a link between maternal lipids and newborn weight as well as other adverse pregnancy outcomes. Maternal lipids _ serum level, dietary intake and change in maternal lipids during pregnancy may be important in determining not only immediate pregnancy and newborn outcomes but also longer term problems for mother and child. As yet, we do not know whether altering maternal lipids will change outcomes or how to influence lipid levels in practice or how best to approach this.
This research proposal will identify changes in liver-secreted proteins during the development of fatty liver, and in the transition from fatty liver to the more advanced form of liver disease, non-alcoholic steatohepatitis (NASH). Understanding the differences in protein secretion between NASH patients and patients with normal/fatty liver will provide the opportunity to identify disease biomarkers that could be determined from a blood sample. This will provide a major shift in clinical care.
Exploring The Therapeutic Potential Of TRAIL In Diabetes And The Metabolic Syndrome
Funder
National Health and Medical Research Council
Funding Amount
$446,374.00
Summary
TNF-related apoptosis-inducing ligand (TRAIL) is a protein with potentially useful actions in human health and disease. TRAIL is able to prevent atherosclerosis, the cause of heart attacks and strokes. In addition, we have recently shown that its actions on fat and the pancreas may prevent the development of the metabolic syndrome and type 2 diabetes. These studies will explore the therapeutic potential of TRAIL for the prevention of diabetes and heart disease in a range of animal models.
Role Of AMP-activated Protein Kinase In Salt Excretion And Hypertension
Funder
National Health and Medical Research Council
Funding Amount
$133,351.00
Summary
High blood pressure is a significant health problem and may result from the kidneys not being able to get rid of salt properly. The mechanisms underlying this are unclear. I will investigate the role of a kidney protein, called AMPK, in salt excretion in mice. I will also look at the effects that diabetes and obesity have on the function of this protein. The overall aim is to improve the understanding of what causes high blood pressure which will ultimately aid the development of new treatments ....High blood pressure is a significant health problem and may result from the kidneys not being able to get rid of salt properly. The mechanisms underlying this are unclear. I will investigate the role of a kidney protein, called AMPK, in salt excretion in mice. I will also look at the effects that diabetes and obesity have on the function of this protein. The overall aim is to improve the understanding of what causes high blood pressure which will ultimately aid the development of new treatments for it.Read moreRead less
Protective Mechanisms Of MAP Kinase Phosphatase 5 In Adipose Tissue Fibrosis, Hepatic Steatosis And Atherosclerosis
Funder
National Health and Medical Research Council
Funding Amount
$352,729.00
Summary
Obesity and associated complications such as diabetes, non-alcoholic fatty liver disease and atherosclerosis are a serious health burden. Recently, we found that MKP5, a molecule that restricts intracellular signaling, plays a central role in preventing these diseases. This collaborative project will elucidate how precisely MKP5 acts and explore how this molecule can be targeted for the development of novel therapeutic strategies in prevention and treatment of human metabolic diseases.
Determining The Mechanism Of Obesity Induced Elevated Blood Pressure And Glucose Dysregulation.
Funder
National Health and Medical Research Council
Funding Amount
$314,644.00
Summary
My research focuses on determine the link and mechanisms behind the development of metabolic diseases in obesity and specifically determining the reason for the development of diabetes and cardiovascular diseases. In this area I have been able to generate strong physiological techniques which have enabled answering these questions possible, and I endeavor to continue to create and establish new techniques to continue to answer physiological questions.
Restoration Of Cognitive Deficits Induced By Diabetes Through The Modulation Of Cerebrovascular Integrity
Funder
National Health and Medical Research Council
Funding Amount
$261,251.00
Summary
Diabetes is a known risk factor for the development of dementia. However the details of this association have not been known. Recent evidence consistently shows that the integrity of blood vessels in the brain may be central to the onset of dementia, and consistently, damaged brain blood vessels are often reported in diabetic patients and animal models. This project is the first to target in restoring the integrity of those brain blood vessels in order to reverse diabetes-associated dementia.
New Insights Into Diabetes, Cerebrovascular Integrity And Dementia Risk
Funder
National Health and Medical Research Council
Funding Amount
$307,946.00
Summary
Studies report that subjects with diabetic insulin resistance are at higher risk of developing dementia. Recent data suggest that disturbances in specialized blood vessels of the brain are responsible for the association between diabetes and dementia. This project will utilize state-of-art methodologies to visually explore if drugs commonly used to treat diabetes, provide cerebrovascular benefits.