Is Leaky Gut A Precursor To Inflammatory Bowel Disease?
Funder
National Health and Medical Research Council
Funding Amount
$89,176.00
Summary
Inflammatory Bowel Diseases (IBD) are chronic idiopathic diseases, characterised by episodes of relapse and remission of intestinal inflammation. Whilst the exact cause remains unknown, there is mounting evidence that a defect exists in the gut lining protecting the body in patients who develop IBD allowing bacterial antigens to enter the body. We aim to use novel imaging combined with colonoscopy called confocal endomicroscopy to image the bowel lining at high power to demonstrate this defect.
Gene Therapy And Bone Marrow Transplantation For Treatment Of Experimental Autoimmune Uveitis
Funder
National Health and Medical Research Council
Funding Amount
$78,445.00
Summary
Bone marrow stem cells modified to express self antigen is proposed as a treatment for experimental autoimmune uveitis. A major goal of this research is to investigate the impact and possible mechanism of gene therapy on the development and progression of autoimmune disease in the eye to prevent or reduce the severity of disease.