I am a pharmacologist-cell biologist-molecular biologist and chemist examining the metabolism of iron in normal and neoplastic cells and the development of iron chelators for the treatment of a variety of diseases e.g., ?-thalassaemia and cancer.
I am a molecular biologist interested in understanding how cells are able to actively kill themselves, and how cells make the decision to live or die. Understanding how cells kill themselves will ultimately lead to better therapies designed to kill cancer
I am cellular immunologist determining the important host immune cell types and effector molecules that control tumour initiation, growth, and metastasis.
Cancer immunology has emerged as a fundamental discipline of oncology and overwhelming new data from large patient studies reveals the importance of the immune reaction in patient prognosis. Professor Smyth has established a large body of work indicating that the immune reaction is rate limiting for the development of tumours. His previous fundamental work forms a platform to launch new studies that will greatly increase the sophistication with which we understand the various immune mechanisms t ....Cancer immunology has emerged as a fundamental discipline of oncology and overwhelming new data from large patient studies reveals the importance of the immune reaction in patient prognosis. Professor Smyth has established a large body of work indicating that the immune reaction is rate limiting for the development of tumours. His previous fundamental work forms a platform to launch new studies that will greatly increase the sophistication with which we understand the various immune mechanisms that control tumour initiation, growth and metastases. It is a major goal of Professor Smyth’s Australia Fellowship to understand why some tumours may be controlled by the immune response while others are apparently not. He has established mouse models of cancer where these questions can be directly addressed for the first time.Read moreRead less
I am a molecular-cell biologist determining the molecular regulation, cellular localisation and function of tumour suppressor proteins in cancer. We aim to elucidate pathways that can ultimately be targeted for intervention in breast and colon cancer.
My research straddles biochemistry, cell biology and immunology. I am interested in the mechanisms of antigen presentation by dendritic cells, and the functions of the cystatin family of protease inhibitors.