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Finally New Tools Are Available To Combat Drug Resistant Tuberculosis, But How Do We Make Them Work? Models To Determine Effective Implementation Strategies In Australia And Our Region
Funder
National Health and Medical Research Council
Funding Amount
$1,562,250.00
Summary
The risk of drug resistance in tuberculosis (MDR TB) is thwarting control efforts and must be addressed. Potential strategies being considered are; treating MDR TB in the latent phase, using new short-course treatment for active TB and using new vaccines. My work develops simulation models to test strategies before they are implemented, to maximise impact and avoid costly or low-impact interventions. I will examine strategies in Australia and in high burden countries in Australia’s region.
Improving The Diagnosis, Treatment And Prevention Of Infectious Diseases In Children
Funder
National Health and Medical Research Council
Funding Amount
$2,410,857.00
Summary
I am a clinician scientist whose research team bridges the gap between laboratory and clinical research to reduce the impact of childhood infectious diseases worldwide. The two main themes within my research program are: 1. Improving the diagnosis of childhood tuberculosis (TB) in resource-poor settings. 2. Understanding how BCG, the vaccine used to protect against TB, reduces other childhood illnesses, including non-TB infections, allergies, eczema and asthma.
Tuberculosis Elimination In Australia Through Targeting Latent Infection
Funder
National Health and Medical Research Council
Funding Amount
$950,000.00
Summary
Australia has committed to reducing the number of people who become sick with tuberculosis (TB), towards eventual elimination. Identification of those at risk is needed, which means significant expansion of detection and treatment of latent TB. This research will evaluate impact, cost-effectiveness and community priorities around TB elimination, and introduce a GP-based treatment service for safe and accessible care. It will provide a basis for large-scale programs towards TB elimination.
Spatially Targeted Intervention For Eliminating Tuberculosis In High-burden Countries
Funder
National Health and Medical Research Council
Funding Amount
$645,205.00
Summary
The overall goal of my research program is to design and implement an innovative approach for eliminating TB in high-burden countries such as Ethiopia and China. My project will integrate contemporary and sophisticated analytical methods (geospatial methods, network meta-analysis and economic analysis) within a single translational research framework and provide evidence to make a substantial shift from the current paradigm of passive case detection.
Is The Excess Mortality Amongst Tuberculosis Survivors Explained By Chronic Pulmonary Aspergillosis? Investigating Burden, Diagnosis, And Therapy
Funder
National Health and Medical Research Council
Funding Amount
$645,205.00
Summary
Chronic pulmonary aspergillosis (CPA) is a serious lung infection due to the mould Aspergillus. It affects people with damaged lungs, such as those who have had tuberculosis. In Vietnam, TB is extremely common, and there should be many cases of CPA. However, because diagnostic facilities are poor, CPA is often wrongly labelled as failed TB treatment, and patients receive the wrong therapy. My research will determine the size of the problem in Vietnam and how best to address it.