I am a clinician-scientist in infectious and tropical diseases, working towards the better understanding of the pathophysiology of malaria and other tropical diseases of public health importance in our region, and new ways of prevention and treatment.
Improving Health Outcomes In The Tropical North: A Multidisciplinary Collaboration
Funder
National Health and Medical Research Council
Funding Amount
$5,997,916.00
Summary
Improving Health Outcomes in the Tropical North will strengthen partnerships with research institutions in the NT, Qld, WA, NSW, Vic and SA, by undertaking a research agenda that will help close the gap in Indigenous health disadvantage, protect the north from emerging infectious threats and engage regional neighbours. We will establish a northern Australian network that incorporates Indigenous engagement, mentoring and knowledge translation, and facilitates collaboration with southern partners.
Linking Genomics Of Burkholderia Pseudomallei To Melioidosis: Diversity Of Clinical Manifestations, Changing Epidemiology And Microevolution In Chronic Carriage.
Funder
National Health and Medical Research Council
Funding Amount
$602,769.00
Summary
The Darwin Prospective Melioidosis Study has documented 761 cases since 1989, with 102 fatalities. This study has led to improved therapy and public health initiatives. New technology to sequence whole bacterial genomes provides an opportunity to determine why urban melioidosis is increasing and to analyse this unique 22+ year set of bacteria and their linked patient data to find the important bacterial virulence factors, forming a foundation for future diagnostics, therapeutics, and vaccines.
Immunity And Pathogenesis In Tropical And Infectious Diseases: Implications For Vaccines And
Funder
National Health and Medical Research Council
Funding Amount
$15,794,553.00
Summary
Malaria, streptococcal diseases, helminthiases and scabies are diseases of indigenous people on a massive scale, which lack vaccines. We aim to understand the pathogenesis of these diseases and develop vaccines and other treatments to combat them. Team includes senior experts on infectious diseases with long collaborative histories and younger members with impressive credentials. The work proposed also concerns inventive new ways of making such vaccines by novel chemical methods and aspects of d ....Malaria, streptococcal diseases, helminthiases and scabies are diseases of indigenous people on a massive scale, which lack vaccines. We aim to understand the pathogenesis of these diseases and develop vaccines and other treatments to combat them. Team includes senior experts on infectious diseases with long collaborative histories and younger members with impressive credentials. The work proposed also concerns inventive new ways of making such vaccines by novel chemical methods and aspects of delivery.Read moreRead less
Exploring Resistance Of Plasmodium Vivax To Antimalarial Drugs: A Retrospective And Prospective Study
Funder
National Health and Medical Research Council
Funding Amount
$439,230.00
Summary
Although previously considered a 'benign' form of the disease, vivax malaria is increasingly recognised as a cause of complications and even death. Unfortunately, the parasite is developing resistance to conventional drugs. Papua New Guinea was where resistance to chloroquine was first detected and other drugs are following suit. We plan to examine the parasite genes involved in this process, including before and after the introduction of a new strategy in PNG, artemisinin combination therapy.
This Fellowship will provide support for the Marshall Centre which is providing research and research training in the fields of bacteriology, epidemiology and vaccinology. It has significant regional collaborative links. Molecular epidemiology and pathogenesis of Helicobacter pylori, the stomach bacteria which causes ulcers and for which Warren and Marshall won the 2005 Nobel Prize in Medicine. Development of animal models to study the immune response so that the new bacterium can be used as a v ....This Fellowship will provide support for the Marshall Centre which is providing research and research training in the fields of bacteriology, epidemiology and vaccinology. It has significant regional collaborative links. Molecular epidemiology and pathogenesis of Helicobacter pylori, the stomach bacteria which causes ulcers and for which Warren and Marshall won the 2005 Nobel Prize in Medicine. Development of animal models to study the immune response so that the new bacterium can be used as a vaccine delivery agent.Read moreRead less
Control Of Neglected Tropical Diseases In The Pacific: Integration Of Programs To Increase Their Impact
Funder
National Health and Medical Research Council
Funding Amount
$1,499,801.00
Summary
Our goal is to improve programs to control neglected tropical diseases, diseases of poverty common in Australia's neighbours: Papua New Guinea, Solomon Islands and Vanuatu. Our partners are supporting the Ministries of Health in these countries to implement integrated programs to better control these diseases. Our multidisciplinary research will use improved diagnostics, spatial mapping, health systems, social science and health economics to evaluate this integrated approach to disease control.
The Darwin Prospective Melioidosis Study: Years 27-31
Funder
National Health and Medical Research Council
Funding Amount
$1,281,718.00
Summary
The Darwin Prospective Melioidosis Study has documented 914 cases since 1989, with 115 fatalities. A surge in Darwin melioidosis cases over the past 5 years has been linked to urban development and the discovery of a new bacterial strain. Whole genome sequencing of our unique 25+ year set of bacteria and their linked patient data will unravel the changing epidemiology and identify important virulence factors, forming a foundation for future diagnostics, therapeutics, and vaccines.