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Investigating The Utility Of Therapeutic Drug Monitoring Of Beta-lactam Antibiotics In Hospitalised Patients
Funder
National Health and Medical Research Council
Funding Amount
$215,887.00
Summary
The appropriate dosing of antibiotics for patients admitted to hospital is based on broad guidelines derived from studies in healthy volunteers or in patients that may have different types of infections. Minor changes in the clinical state of the patients can require significant dosing adjustments. The best way to guarantee appropriate antibiotic therapy is to individualize doses based on blood concentration data. We aim to determine the utility of dose adjustment in hospitalized patients.
Broad Spectrum Inhibition Of An Enzyme Antibiotic Target
Funder
National Health and Medical Research Council
Funding Amount
$321,534.00
Summary
There is a well-documented need to replenish the antibiotic pipeline with new products to combat the rise of drug resistant bacteria. In this project, the enzyme dihydrodipicolinate synthase (DHDPS) is targetted which is essential to bacterial viability. A number of independent but synergistic drug discovery approaches are investigated to develop and test DHDPS inhibitors in the pursuit of a novel class of antibiotics.
Assessing The Biogeography Of The Ocular Microbiota And The Impact Of Antibiotic Prophylaxis
Funder
National Health and Medical Research Council
Funding Amount
$314,644.00
Summary
Using DNA sequencing, recent studies have identified a diverse community of bacteria on the eye, once believed to be sparsely populated by microbes. This project will identify what is the resident bacteria of the eye and where these bacteria reside on the eye. Also, after cataract surgery some individuals experience dry eye problems. This project will investigate if antibiotic therapy, necessary to prevent infection, disrupts the microbial communities on the eye leading to development of dry eye
Novel Antibiotics Targeting Bacterial Secretion Systems
Funder
National Health and Medical Research Council
Funding Amount
$303,357.00
Summary
Infection caused by pathogenic bacteria is a major health concern. Strains of bacteria are constantly becoming resistant to front line antibiotics, driving the need for more effective treatments. A drug target that is not currently utilized in clinical treatment is a family of molecular nano-machines embedded in the bacterial cell wall. These machines are called sectretins. The aim of this research is to fundamentally understand their molecular architecture in order to guide the design of potent ....Infection caused by pathogenic bacteria is a major health concern. Strains of bacteria are constantly becoming resistant to front line antibiotics, driving the need for more effective treatments. A drug target that is not currently utilized in clinical treatment is a family of molecular nano-machines embedded in the bacterial cell wall. These machines are called sectretins. The aim of this research is to fundamentally understand their molecular architecture in order to guide the design of potent and selective inhibitory drugs.Read moreRead less
Improving Outcomes Of Severe Bacterial Infections In Northern Australia
Funder
National Health and Medical Research Council
Funding Amount
$217,274.00
Summary
Severe infections such as pneumonia can cause failure of vital organs (severe sepsis) and subsequent death. 30-40% of people who develop severe sepsis die, even with the best modern therapies. Sepsis is five times more common in northern Australia than elsewhere. In this program of research, we plan to test new therapies for sepsis; to determine the causes of and risk factors for severe pneumonia in northern Australia; and to use this information to inform new guidelines for the management of se ....Severe infections such as pneumonia can cause failure of vital organs (severe sepsis) and subsequent death. 30-40% of people who develop severe sepsis die, even with the best modern therapies. Sepsis is five times more common in northern Australia than elsewhere. In this program of research, we plan to test new therapies for sepsis; to determine the causes of and risk factors for severe pneumonia in northern Australia; and to use this information to inform new guidelines for the management of sepsis and pneumonia in northern Australia.Read moreRead less
Improving Translation Of Intensity And Quality Of Upper Limb Rehabilitation Provided By Occupational Therapists To Children With Unilateral Cerebral Palsy: A Cluster Randomised Controlled Trial
Funder
National Health and Medical Research Council
Funding Amount
$225,539.00
Summary
This study aims to increase occupational therapist's use of best available evidence of intensive upper limb therapy for children with unilateral cerebral palsy. The study will determine in a cluster randomised trial whether a multifaceted implementation program comprising: (a) audit & feedback, (b) identifying barriers to implementing best practice evidence, and (c) targeted interactive training is more effective than a single faceted program (audit & feedback alone) to increase evidence uptake.
Cerebral palsy is the most common physical disability in children. Rehabilitation focuses on improving hand use to enhance daily care, access to education and vocational aspirations. This research aims to change the type of rehabilitation therapists use to treat hand and arm problems and use more current training approaches which have been shown to improve hand and arm skills.
Engineering Powder Aerosols Of Antibacterial Nanomedicines For Treatment Of Respiratory Infections
Funder
National Health and Medical Research Council
Funding Amount
$195,338.00
Summary
This project aims to apply cutting-edge nanotechnology to develop new inhalation therapy for respiratory infections by delivering antibiotics directly to the lungs. The expected outcomes of this work are more efficacious, safer and cost effective treatments for patients suffering from respiratory infectious diseases such as pneumonia.