Nanoengineering materials to combat antimicrobial resistance. This project aims to understand how nanoengineered materials can be designed to kill bacteria and fungi without causing antimicrobial resistance. Resistance to antimicrobial drugs already leads to many thousands of deaths annually and costs society billions of dollars. Nanomaterials have unique abilities to attack microbes in multiple ways that could limit resistance. This project will engineer new antimicrobial nanomaterials tailored ....Nanoengineering materials to combat antimicrobial resistance. This project aims to understand how nanoengineered materials can be designed to kill bacteria and fungi without causing antimicrobial resistance. Resistance to antimicrobial drugs already leads to many thousands of deaths annually and costs society billions of dollars. Nanomaterials have unique abilities to attack microbes in multiple ways that could limit resistance. This project will engineer new antimicrobial nanomaterials tailored to selectively kill microbes with reduced likelihood of developing resistance by using synergies between inorganic nanoparticles and antimicrobial peptides. This technology could be used to prevent infections and biofilms on surfaces in a wide range of future applications, such as medical / veterinary devicesRead moreRead less
Orientated biointerfacing of cell-mimetic nanoparticles. The project aims to create next-generation cell-mimetic nanotechnology by providing in-depth understandings and precise control over cell membrane coating orientation of biomimetic nanoparticles. Our approach is to design and develop new synthetic and analytic strategies to construct and quantify orientated biointerfacing. This will generate new knowledge and patentable methodologies related to orientated biomimetic nanoparticles. Expected ....Orientated biointerfacing of cell-mimetic nanoparticles. The project aims to create next-generation cell-mimetic nanotechnology by providing in-depth understandings and precise control over cell membrane coating orientation of biomimetic nanoparticles. Our approach is to design and develop new synthetic and analytic strategies to construct and quantify orientated biointerfacing. This will generate new knowledge and patentable methodologies related to orientated biomimetic nanoparticles. Expected outcomes include significant contributions to Australia's scholarly outputs, enhanced national capacity in disruptive nanotechnology, new opportunities for national value-add material manufacturing, and long-term benefits to biomedical and veterinary industries through new materials and nanotechnologies.
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AI Assisted Continuous Flow Electrochemistry for Pharmaceutical Manufacture. This project aims to develop new chemical manufacturing processes for pharmaceutical products. In collaboration with Sun Pharma, it will tackle the challenge of replacing expensive and toxic chemicals in industrial reactions, to lower cost of manufacturing and improve its sustainability profile. Central to the realisation of this ambition is the use of electrocatalysis, machine learning and implementation of advanced co ....AI Assisted Continuous Flow Electrochemistry for Pharmaceutical Manufacture. This project aims to develop new chemical manufacturing processes for pharmaceutical products. In collaboration with Sun Pharma, it will tackle the challenge of replacing expensive and toxic chemicals in industrial reactions, to lower cost of manufacturing and improve its sustainability profile. Central to the realisation of this ambition is the use of electrocatalysis, machine learning and implementation of advanced continuous flow methods. These electricity- and technology-driven reactions will develop new strategies for the generation of important classes of molecules relevant to the Australia’s pharmaceutical sector, as well as their manufacture at industrially relevant scales.Read moreRead less
Next Generation Polymeric Scaffolds For Dual Agent Delivery. This project aims to provide a novel suite of degradable polymeric scaffolds for releasing multiple active agents with tailored release profiles by utilising both polymer and small molecule synthesis techniques. The project expects to generate new copolymers and polymer networks that exploit molecular architecture to regulate the release profile of the active agents incorporated. The expected outcome is the establishment of design crit ....Next Generation Polymeric Scaffolds For Dual Agent Delivery. This project aims to provide a novel suite of degradable polymeric scaffolds for releasing multiple active agents with tailored release profiles by utilising both polymer and small molecule synthesis techniques. The project expects to generate new copolymers and polymer networks that exploit molecular architecture to regulate the release profile of the active agents incorporated. The expected outcome is the establishment of design criteria for tailoring the release of active agent from the polymer scaffold. This should provide significant benefits by developing a new technology platform that could be readily adapted to applications in agriculture, pharmaceutical science and veterinary medicine where controlled release is required.
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Antibacterial Material Design via Mechanism-Based Mathematical Modelling. This Project aims to provide new rules for the design of novel polymer materials with antibacterial properties by employing mechanism-based mathematical modelling.
This Project expects to generate new understanding of those mechanisms which underpin the antibacterial activity of these materials, how bacteria respond to these through metabolic changes and emergence of resistance.These rules will govern material design to yi ....Antibacterial Material Design via Mechanism-Based Mathematical Modelling. This Project aims to provide new rules for the design of novel polymer materials with antibacterial properties by employing mechanism-based mathematical modelling.
This Project expects to generate new understanding of those mechanisms which underpin the antibacterial activity of these materials, how bacteria respond to these through metabolic changes and emergence of resistance.These rules will govern material design to yield new antibacterial materials with improved properties.
Expected outcomes of this project may be a novel mechanism-based mathematical model that will enable the next-generation of antibacterial materials.
This outcome will help address the increasing economic and social burden of antibiotic drug resistance in Australia.
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Unleashing the Hidden Chemical Diversity in Australian Fungi. This project aims to exploit an exclusive genomic resource consisting of >150 unique Australian filamentous fungi that has been built in a university-industry collaboration for genomic-guided biodiscovery. The genome sequence of these fungi revealed extensive hidden genetic instructions for production of novel biologically active molecules. The project will apply cutting-edge synthetic biology and chemical tools to tap into the hidden ....Unleashing the Hidden Chemical Diversity in Australian Fungi. This project aims to exploit an exclusive genomic resource consisting of >150 unique Australian filamentous fungi that has been built in a university-industry collaboration for genomic-guided biodiscovery. The genome sequence of these fungi revealed extensive hidden genetic instructions for production of novel biologically active molecules. The project will apply cutting-edge synthetic biology and chemical tools to tap into the hidden genomic potential of these Australian fungi. Expected outcomes of this project include new fine chemicals and lead molecules with desirable bioactivies. This will provide significant benefits to Australia's economy through the discovery of new pharmaceuticals, veterinary products and agrichemicals.Read moreRead less
Artificial intelligence to explore and combat eukaryotic pathogens. The revolution in artificial intelligence (AI) provides unprecedented opportunities for integrative analyses of complex multi-omics data sets and for creating radically new strategies to control some of the world’s most serious animal diseases. In a strong partnership with international experts, we will use AI-based methods to make major conceptual advances in our understanding of eukaryotic pathogens and host-pathogen interacti ....Artificial intelligence to explore and combat eukaryotic pathogens. The revolution in artificial intelligence (AI) provides unprecedented opportunities for integrative analyses of complex multi-omics data sets and for creating radically new strategies to control some of the world’s most serious animal diseases. In a strong partnership with international experts, we will use AI-based methods to make major conceptual advances in our understanding of eukaryotic pathogens and host-pathogen interactions, discover the "choke-points" in biological pathways, and develop novel treatments, vaccines and diagnostics. This leap forward will substantially enhance the global profile of pathogen research in Australia, build major capacity in a priority area, and enable access to international research funding and networks.Read moreRead less
Australian Laureate Fellowships - Grant ID: FL200100220
Funder
Australian Research Council
Funding Amount
$3,364,492.00
Summary
Understanding host-microbiome signalling axes in ageing. Ageing is an inevitable biological phenomenon and is characterised by alterations in multiple biochemical, immunological and mechanical processes, which are influenced by the gut bacteria. Poor ageing exerts a heavy socioeconomic burden both nationally and globally. The aim of this proposal is to deepen understanding of host-microbiome signalling in ageing by bringing together next generation sequencing technologies to characterise age-ass ....Understanding host-microbiome signalling axes in ageing. Ageing is an inevitable biological phenomenon and is characterised by alterations in multiple biochemical, immunological and mechanical processes, which are influenced by the gut bacteria. Poor ageing exerts a heavy socioeconomic burden both nationally and globally. The aim of this proposal is to deepen understanding of host-microbiome signalling in ageing by bringing together next generation sequencing technologies to characterise age-associated change in gut bacterial composition, metabolic profiling to identify changes in functionality of the ageing microbiome and a combination of in vitro and in vivo screening approaches to establish molecular mechanisms. The new knowledge will facilitate development of improved models of health care.Read moreRead less
Intelligent Robotics for Pharmaceutical Formulation Development. This project aims to transform the labour and time-intensive process of drug formulation development by optimising the process workflow, through collaboration between biochemists and the proposed intelligent and scalable robotic system. This project expects to enable the robot to leverage the expert knowledge of the biochemists while automating rote tasks. The expected outcome of this project is an intelligent robot that can collab ....Intelligent Robotics for Pharmaceutical Formulation Development. This project aims to transform the labour and time-intensive process of drug formulation development by optimising the process workflow, through collaboration between biochemists and the proposed intelligent and scalable robotic system. This project expects to enable the robot to leverage the expert knowledge of the biochemists while automating rote tasks. The expected outcome of this project is an intelligent robot that can collaborate with human coworkers to accelerate drug formulation. This should provide significant benefits by lowering drug costs and the development time of new drugs. Read moreRead less
Australian Laureate Fellowships - Grant ID: FL210100071
Funder
Australian Research Council
Funding Amount
$3,246,000.00
Summary
“L-form” bacteria: basic science, antibiotics, evolution and biotechnology. This Fellowship addresses key gaps in knowledge about cell wall deficient bacteria called L-forms: an altered state of bacteria with intriguing properties both structurally and functionally. The main aims of the research program are to improve our understanding of the basic biology of L-forms and employ them as tools in several important ways: for understanding the mechanisms of cell wall synthesis and how antibiotics wo ....“L-form” bacteria: basic science, antibiotics, evolution and biotechnology. This Fellowship addresses key gaps in knowledge about cell wall deficient bacteria called L-forms: an altered state of bacteria with intriguing properties both structurally and functionally. The main aims of the research program are to improve our understanding of the basic biology of L-forms and employ them as tools in several important ways: for understanding the mechanisms of cell wall synthesis and how antibiotics work, as models for early steps in the evolution of cellular life, and as a significant new platform for the production of proteins and fine chemicals. Outcomes and benefits include improved understanding of how to generate new antibiotics, and the development of new platforms for Australian biotechnology and biocommerce.Read moreRead less