Prevention Of Multi-drug Resistant Tuberculosis In A High Prevalence Setting: ‘Connecting The DOTS’ In Vietnam
Funder
National Health and Medical Research Council
Funding Amount
$3,382,020.00
Summary
The close contacts of people with multi-drug resistant tuberculosis (MDR-TB) have a high risk of developing the disease. The V-QUIN MDR-TB Trial will evaluate the effectiveness of an oral antibiotic (levofloxacin) in preventing drug resistant TB among infected household contacts of TB patients. Household contacts from 10 Provinces in Vietnam will be randomly allocated to receive six-months of either levofloxacin or a placebo, and then followed for two years to see if they develop tuberculosis.
Osteoporotic Fracture-Mortality Association And The Effect Of Anti-osteoporosis Treatment: A Multinational Study
Funder
National Health and Medical Research Council
Funding Amount
$84,800.00
Summary
Osteoporosis burden is due primarily to osteoporotic fractures resulting in economic and public health burden, increased disability, further fracture risk and more importantly early death. However, it remains under-treated although treatment reduces the number of fractures and may reduce early death. This study aims to understand which types of fractures result in early death and for which age groups and whether osteoporosis treatment does or does not reduce early death.
Explaining The Causal Effect Of Obesity On Colorectal And Postmenopausal Breast Cancer
Funder
National Health and Medical Research Council
Funding Amount
$51,834.00
Summary
With rising rates in Australia and globally, obesity is fast surpassing smoking to become the biggest preventable cause of cancer. While losing weight might reduce the risk of cancer, most people find this hard to do. In this project, possible mechanisms linking obesity to bowel and postmenopausal breast cancer will be studied to work out how important they are for each cancer. Ultimately, the goal is to help design strategies for prevention and early detection of cancers caused by obesity.
Use Of Statistical And Mathematical Models To Investigate Infectious Disease Transmission Dynamics To Better Inform Control Measures In Hospitals And The Community
Funder
National Health and Medical Research Council
Funding Amount
$408,388.00
Summary
Globally tuberculosis infects over 9 million people yearly. In low incidence countries TB is re-emerging, with HIV, drug resistance and migration driving this. Australia needs to examine the transmission of TB within our country and The Asia-Pacific region. This proposal will quantify the risk for importation of highly drug resistant TB into Australia and assess the factors that lead to outbreaks. Models will be informative for Australian TB policy development and contribute to regional and glob ....Globally tuberculosis infects over 9 million people yearly. In low incidence countries TB is re-emerging, with HIV, drug resistance and migration driving this. Australia needs to examine the transmission of TB within our country and The Asia-Pacific region. This proposal will quantify the risk for importation of highly drug resistant TB into Australia and assess the factors that lead to outbreaks. Models will be informative for Australian TB policy development and contribute to regional and global efforts for TB control.Read moreRead less
Testing And Treatment For Prostate Cancer In Australia: Epidemiology And Modelling
Funder
National Health and Medical Research Council
Funding Amount
$267,886.00
Summary
We aim to use observational data and mathematical modelling to investigate testing and treatment for prostate cancer in Australia. We will incorporate changes in prostate-specific antigen (PSA) testing and in clinical practice to investigate: a) over-diagnosis, being cancer cases diagnosed through PSA testing that would not have been otherwise diagnosed; b) the effect of PSA testing on prostate cancer mortality; and c) mortality and health care use under different PSA test scenarios.
Who To Treat, When To Treat And How To Treat Prostate Cancer: Generating Evidence To Guide Prostate Cancer Treatment Decisions
Funder
National Health and Medical Research Council
Funding Amount
$408,768.00
Summary
There is considerable uncertainty about which treatments lead to better outcomes for men with prostate cancer and whether treatment is always necessary. This project will compare different treatment options for prostate cancer, including active surveillance, to determine which offers the best chance of survival and least harm to men’s physical and mental wellbeing. It will also explore whether some men who do not receive active treatment (healthy older men) would benefit if they did.