Exploring The Efficacy And Biobehavioural Basis Of Baclofen In The Treatment Of Alcoholic Liver Disease.
Funder
National Health and Medical Research Council
Funding Amount
$661,197.00
Summary
Alcoholic liver disease (ALD) is the main cause of death from alcohol consumption. Early detection of the disease and subsequent abstinence from alcohol can prevent death and disability. Current medications to help control alcohol consumption are not suitable for use in this patient population owing to the risk of liver side-effects. This study investigates the novel use of an existing medication, baclofen, to safely help maintain abstinence from alcohol in patients suffering from ALD.
The N-ICE Trial: A Randomised Controlled Trial Of The Safety And Efficacy Of N-Acetyl Cysteine (NAC) As A Pharmacotherapy For Methamphetamine (“ice”) Dependence
Funder
National Health and Medical Research Council
Funding Amount
$1,551,368.00
Summary
Crystalline methamphetamine (aka ‘ice’) is a significant public health concern in Australia and globally. Currently there are no approved medications to treat methamphetamine dependence. We will trial tN-acetyl-cysteine (NAC) as a medications for methamphetamine dependence.
Standalone Internet Anxiety Treatment For Stuttering: A Randomised Trial
Funder
National Health and Medical Research Council
Funding Amount
$516,339.00
Summary
Anxiety-related mental health disorders, particularly social phobia, are common comorbid conditions among adults who stutter. This project establishes randomised controlled trial evidence for the psychological benefits of our Internet CBT treatment. This project also establishes whether our Internet CBT treatment reduces stuttering severity when combined with speech treatment. The design is an open plan, parallel, pragmatic randomised controlled trial.
Randomised Control Trial Of Exercise For The Management Of Cannabis Withdrawal In Adult Humans
Funder
National Health and Medical Research Council
Funding Amount
$542,036.00
Summary
This project will evaluate a novel approach to cannabis detoxification. It is hypothesized that undertaking an exercise intervention will reduce cannabis withdrawal symptoms by stimulating the release of cannabis-like compounds produced by the body and/or through promoting the release of THC (the main psychoactive component of cannabis) from fat stores. The potential public health, research and clinical implications are considerable, particularly given the high accessibility of the intervention.
A Stepped Care Approach For The Management Of Childhood Anxiety Disorders: A Randomised Controlled Trial
Funder
National Health and Medical Research Council
Funding Amount
$936,628.00
Summary
Anxiety disorders are the most common form of mental disorder in childhood. Research has led to some good treatments but these don't necessarily suit all families. Stepped care is a format that allows the least complicated treatment to be given to a child first, followed by more intense treatments only when needed. The current study aims to compare this approach against a standard, established treatment. We expect the stepped care approach to result in better outcomes at a lower overall cost.
The Efficacy Of Behavioural Activation Therapy In Treating Depression Among Individuals With Opioid Dependence
Funder
National Health and Medical Research Council
Funding Amount
$733,908.00
Summary
Heroin dependence is a chronic relapsing condition, associated with high levels of psychopathology. On entry to treatment at least one quarter of heroin users meet criteria for Major Depression. The co-occurrence of heroin dependence and depression is associated with a range of harms and has been linked to poorer treatment outcomes. Despite this, practical and effective treatment options are scarce. The proposed international collaboration will contribute significantly to understanding of the tr ....Heroin dependence is a chronic relapsing condition, associated with high levels of psychopathology. On entry to treatment at least one quarter of heroin users meet criteria for Major Depression. The co-occurrence of heroin dependence and depression is associated with a range of harms and has been linked to poorer treatment outcomes. Despite this, practical and effective treatment options are scarce. The proposed international collaboration will contribute significantly to understanding of the treatment of this comorbidity.Read moreRead less