Improving Alcohol Treatment Outcomes: The Impact Of Client, Intervention And System Variables On Treatment Outcomes.
Funder
National Health and Medical Research Council
Funding Amount
$1,525,879.00
Summary
Patient outcomes are significantly influenced by a number of factors including the characteristics of the patient, the type of treatment provided, and the characteristics of the system in which care is delivered. This study aims to determine how these factors influence outcomes for people seeking treatment for alcohol dependence. It will provide critical information for policy makers on which to base minimum service standards.
Fracture Associated Premature Mortality; An International Consortium
Funder
National Health and Medical Research Council
Funding Amount
$579,807.00
Summary
Following an osteoporotic fracture there is an increased premature mortality compared with someone who has not fractured. There is also evidence that anti-osteoporosis medication reduces this premature mortality. This study will determine the size of the fracture-mortality relationship and the effect of treatment on this mortality for different fracture types and in different populations by integrating data from multiple international epidemiology studies of osteoporosis.
Clinical Outcomes With Electroconvulsive Therapy: Insights From Computational Modelling
Funder
National Health and Medical Research Council
Funding Amount
$347,767.00
Summary
Electroconvulsive therapy (ECT) is the treatment of choice for severe, resistant depression. However it use is reduced by concerns about memory problems. The effectiveness and side effects of ECT depend on how it is given, but clinical trials can only test 1 variation at a time. This study will use sophisticated computational modelling to understand how varying the treatment approach affects clinical outcomes, allowing the development of next-generation, custom-designed ECT treatment.
Quantifying The Burden Of Atrial Fibrillation: Impact Of Existing And New Treatments And The Potential For Prevention
Funder
National Health and Medical Research Council
Funding Amount
$398,395.00
Summary
Atrial fibrillation (AF) causes considerable morbidity and burden to the Australian economy. We will quantify the prevalent burden and costs of hospitalised AF, ascertain the risk of major events associated with AF and the impact of existing treatments, and determine the population-attributable risk for AF due to emerging risk factors. Our data will inform clinicians and health policy makers regarding the most effective allocation of expensive health care resources to minimise the burden of AF.
How Are Periodontal Disease And Rheumatoid Arthritis Inter-related?
Funder
National Health and Medical Research Council
Funding Amount
$563,262.00
Summary
Periodontal (gum) disease and rheumatoid arthritis are two of the most common chronic inflammatory diseases affecting humans. These two diseases have remarkably similar patterns of tissue destruction. It is possible that chronic periodontitis may prime or predispose susceptible individuals to developing rheumatoid arthritis. Treatment of periodontal disease may help reduce the severity of rheumatoid arthritis.
Studies Of The Role Of The Hepatocyte In The Response To HCV Infection
Funder
National Health and Medical Research Council
Funding Amount
$513,294.00
Summary
Infection with hepatitis C (HCV) affects 120 million individuals worldwide, and over 200,000 in Australia. HCV-related liver disease is the most common indication for liver transplantation in Australia and rates of HCV-related liver failure and hepatocellular cancer are predicted to increase as the HCV population ages. A new test for the IL28B gene, has shown to be the strongest predictor of cure after treatment. The mechanism of this association is unknown and is the subject of this grant.
Standalone Internet Anxiety Treatment For Stuttering: A Randomised Trial
Funder
National Health and Medical Research Council
Funding Amount
$516,339.00
Summary
Anxiety-related mental health disorders, particularly social phobia, are common comorbid conditions among adults who stutter. This project establishes randomised controlled trial evidence for the psychological benefits of our Internet CBT treatment. This project also establishes whether our Internet CBT treatment reduces stuttering severity when combined with speech treatment. The design is an open plan, parallel, pragmatic randomised controlled trial.
ASTROID: Active Surveillance And Other TReatment OptIons For Prostate Cancer. A Randomised Controlled Trial Of Decision Aid And DVD Information Support For Men Diagnosed With Low-risk Prostate Cancer And Their Partners
Funder
National Health and Medical Research Council
Funding Amount
$782,369.00
Summary
This summary was provided in the grant application.
Using Pharmacogenetics To Personalize Treatment Outcome To Ranibizumab (Lucentis) For The Eye Disease Age-related Macular Degeneration (AMD)
Funder
National Health and Medical Research Council
Funding Amount
$623,891.00
Summary
The drug Lucentis has revolutionized the treatment of age-related macular degeneration, one of the commonest causes of severe vision loss in Australia. Unfortunately, up to 25% of patients continue to lose vision despite this treatment. We will use the latest gene chip technology to identify the genetic variant responsible for this poor response. Having this information will allow us to personalise treatment for the patient leading to improvement in their vision.
Enhancing Cognitive Behavioural Treatment Outcomes For Social Phobia
Funder
National Health and Medical Research Council
Funding Amount
$344,129.00
Summary
Social phobia is a serious difficulty that has a tremendous impact in an individual's life. Psychological programs for social phobia have yielded relatively strong positive outcomes, however some individuals do not gain the optimum benefit from these programs. This study aims to test the effectiveness of an added component in the treatment for social phobia which focuses on increasing engagement with treatment in order to optimise outcomes.