Hypothermia Prior To Decompression For Treatment Of Acute Spinal Cord Injury
Funder
National Health and Medical Research Council
Funding Amount
$294,163.00
Summary
In spinal cord injuries, the cord is compressed as a result of vertebral injury. Urgent relief of compression improves outcome, however, is difficult because of the complexity of pre-surgical management. Our data demonstrate that hypothermia stops compressive spinal cord injury, allowing decompression to be performed in a period that will benefit most patients. This project aims to undertake the studies necessary before beginning a human trial of hypothermia prior to decompressive surgery.
Proteases And Protease-inhibitor Complexes As Modulators Of Traumatic Brain Injury Severity
Funder
National Health and Medical Research Council
Funding Amount
$613,311.00
Summary
Traumatic brain injury (TBI) is a significant cause of mortality and morbidity in Australia, affecting approximately 21,800 Australians annually. A large number of survivors have permanent neurological deficits, causing adverse effects on lifestyle and family relationships and placing a significant burden on the health system. In this project we will address a novel means to improve TBI outcome by targeting two linked enzyme systems that together have been shown to be deleterious in this conditi ....Traumatic brain injury (TBI) is a significant cause of mortality and morbidity in Australia, affecting approximately 21,800 Australians annually. A large number of survivors have permanent neurological deficits, causing adverse effects on lifestyle and family relationships and placing a significant burden on the health system. In this project we will address a novel means to improve TBI outcome by targeting two linked enzyme systems that together have been shown to be deleterious in this condition.Read moreRead less