The Role Of C-Rel In Controlling Chromatin Architecture And Transcription Networks In T Lymphocytes
Funder
National Health and Medical Research Council
Funding Amount
$531,696.00
Summary
The immune system is poised to respond to invading viruses or bacteria and eliminate them as efficiently as possible. Incorrect activation of the immune system leads to chronic inflammation and autoimmunity. Immune cells can also grow in an uncotrolled manner causing leukamia. The cells of the immune system recognise pathogens and respond by altering the patterns of proteins produced by the cells allowing the system to eliminate the invading organisms. The altered protein production patterns ste ....The immune system is poised to respond to invading viruses or bacteria and eliminate them as efficiently as possible. Incorrect activation of the immune system leads to chronic inflammation and autoimmunity. Immune cells can also grow in an uncotrolled manner causing leukamia. The cells of the immune system recognise pathogens and respond by altering the patterns of proteins produced by the cells allowing the system to eliminate the invading organisms. The altered protein production patterns stem from changes in the gene expression profile of the cells. The gene expression profile of the cell is determinded by the activity of proteins called transcription factors. One such factor, c-Rel, has been implicated in allergy, autoimmunity, in transplant rejection and in leukemia. The aim of this project is to study the function of c-Rel in T cells, an important cell type in the immune system. The overall aim is to understand how c-Rel controls the gene expression profile of T cells so that a rational basis for c-Rel as a drug target can be designed.Read moreRead less
Improved Patient Outcomes Through Dosage Individualisation Of The Newer Immunosuppressant Drugs
Funder
National Health and Medical Research Council
Funding Amount
$486,206.00
Summary
After organ transplantation, recipients need to take medicines continually to stop their immune system from rejecting their new organ. This treatment with immunosuppressant drugs is vital for long-term success of their graft. However, too many people are losing their transplant or are experiencing drug toxicity or infection due to poorly managed immunosuppression. The project aims to accurately define the best way to dose newer immunosuppressant drugs in Australian transplant populations.