The Role Of The HuB RNA-binding Protein In Post-transcriptional Gene Regulation In The Pre-gastrula Zebrafish Embryo
Funder
National Health and Medical Research Council
Funding Amount
$545,216.00
Summary
The precise control of protein expression is absolutely critical in biology. The key decisions about which genes are turned on or off at any one moment control the proper growth of an organism during development, and are responsible for the organism's homeostasis and proper response to environmental changes as an adult. The spatio-temporal control of genes is critcal during embryogenesis and we aim to understand how these processes underlie development in the vertebrate embryo.
This study will provide highly reliable information about the use of tight blood glucose control in critically ill patients. It involves an international collaboration between opinion leaders in this field and uses sophisticated statistical methods to combine data from all the clinical trials in this area. The study will clarify many of the current clinical questions about tight glucose control during critical illness, informing practice guidelines in Australia and around the world.
Imaging And Chemical Biomarkers For Assessing The Effectiveness Of Therapy In The First European Investigator-driven Clinical Trial Investigating The Benefits Of Hypothermia In Ischaemic Stroke Patients
Funder
National Health and Medical Research Council
Funding Amount
$1,048,570.00
Summary
Hypothermia, entering phase III trial in Europe, has the potential to slow brain injury after stroke. It will allow existing thrombolytic therapies which restore critical brain blood flow to be used in many more patients than currently possible. However, hypothermia will soak up valuable resources if non-selectively applied to the ~15 million patients who have a stroke each year. We aim to identify biomarkers to test which patients will benefit most and permit the best resource allocation.
Translating Epilepsy Research Into Clinical Practice
Funder
National Health and Medical Research Council
Funding Amount
$188,226.00
Summary
We aim to turn laboratory science into real improvements in the health of people with epilepsy. Firstly, a rise in the acidity of the blood from breathing less and a rise in carbon dioxide, may contribute to seizures finishing. We aim to develop a safe, rapid, non-sedating way to treat seizures using a small amount of carbon dioxide in oxygen. Secondly, inherited problems with transporting sugar from the blood to the brain are increasingly recognised as a cause of epilepsy. We will develop a nat ....We aim to turn laboratory science into real improvements in the health of people with epilepsy. Firstly, a rise in the acidity of the blood from breathing less and a rise in carbon dioxide, may contribute to seizures finishing. We aim to develop a safe, rapid, non-sedating way to treat seizures using a small amount of carbon dioxide in oxygen. Secondly, inherited problems with transporting sugar from the blood to the brain are increasingly recognised as a cause of epilepsy. We will develop a nation-wide program to identify and treat theseRead moreRead less
Centre For Translational Pathology Research And Training
Funder
National Health and Medical Research Council
Funding Amount
$2,677,639.00
Summary
The Centre for Translational Pathology Research and Training is a collaborative network involving nine hospitals and research institutes affiliated with The University of Melbourne. It's goal is train a cadre of molecular pathologists experienced in collaborative multidisciplinary research who can effective translate research discoveries and inventions in to clinically useful diagnostic tests that will enable oncologists to individualise treatment decisions for patients with cancer, based on the ....The Centre for Translational Pathology Research and Training is a collaborative network involving nine hospitals and research institutes affiliated with The University of Melbourne. It's goal is train a cadre of molecular pathologists experienced in collaborative multidisciplinary research who can effective translate research discoveries and inventions in to clinically useful diagnostic tests that will enable oncologists to individualise treatment decisions for patients with cancer, based on the unique biology of the individual's tumour.Read moreRead less
Building A Bridge Between Animal Models Of Blood Transfusion And Clinical Practice: Development Of Sheep Laboratory Models To Investigate The Effects Of Transfusion
Funder
National Health and Medical Research Council
Funding Amount
$86,117.00
Summary
This research project aims to develop clinically-relevant sheep laboratory models of transfusion that will provide a ‘bridge’ between human laboratory and sheep in vivo models and clinical setting by contributing to a better understanding of the underlying mechanisms of transfusion with stored blood products. Ultimately, addressing key knowledge gaps regarding transfusion of aged and cryopreserved blood products will result in improved outcomes for patients.