Circulating Tumour DNA To Monitor Treatment Response And Resistance In Chronic Lymphocytic Leukaemia
Funder
National Health and Medical Research Council
Funding Amount
$876,950.00
Summary
Many cancers shed small amounts of DNA (ctDNA) into the patient’s bloodstream and recent advances in genomic technologies now allow levels of ctDNA to be accurately measured in the blood. Changes in ctDNA levels have potential to be used as specific markers of disease progression and/or response to cancer therapy. This project will evaluate if ctDNA can be used to monitor treatment responses and individualise treatment decisions in patients with chronic lymphocytic leukaemia.
Investigating Treatments And Biomarkers Of Brain Concussion
Funder
National Health and Medical Research Council
Funding Amount
$428,065.00
Summary
Concussions are a serious and common international health concern, and repeated concussions can have severe long-term consequences on the brain. This project will aim to provide insight into this poorly understood disease projects and ultimately improve the management of concussions in human patients.
National Implementation Trial Of An Evidence-informed Workplace Sitting Reduction Intervention
Funder
National Health and Medical Research Council
Funding Amount
$624,575.00
Summary
Long periods of sitting time are bad for health. We will conduct a three-year national trial with five workplace-health partner organizations testing a website-delivered program for reducing sitting time at work. It will be offered to over 10,000 desk-based employees. We will determine the impacts of the program as well as refinements needed for full-scale dissemination: uptake of the program, how well it can be delivered on a large scale, its impact on sitting time, and the costs involved.
Development Of Vinorelbine As A Tablet Based Therapy To Cure Ectopic Pregnancies
Funder
National Health and Medical Research Council
Funding Amount
$361,594.00
Summary
Ectopic pregnancies occur if the pregnancy implants in the Fallopian tube. They can be deadly and most are treated surgically. We will examine the exciting possibility that instead of surgery, ectopic pregnancies may be cured with a tablet taken just once. We will perform laboratory studies and a clinical trial, giving vinorelbine to women with ectopic pregnancies.
Scalability Of The Transform-Us! Program To Promote Children's Physical Activity And Reduce Prolonged Sitting In Victorian Primary Schools
Funder
National Health and Medical Research Council
Funding Amount
$549,823.00
Summary
Transform-Us! is an innovative primary school program that has been found to substantially increase children’s physical activity levels, reduce sitting time and benefit health. With simple changes to the school and classroom environments and teaching practices (eg, standing lessons) we will work with partners in the education and health systems to translate this program across Victorian primary schools to determine the real-world implementation and impact of this program over 5 years.
Centre For Research Excellence In Stroke Rehabilitation And Brain Recovery
Funder
National Health and Medical Research Council
Funding Amount
$2,595,746.00
Summary
The Centre of Research Excellence in Stroke Rehabilitation and Brain Recovery will transform the stroke research and practice landscape in Australia, and accelerate the development of new interventions strongly supported by neuroscience. This unique collaboration will improve patient selection and rehabilitation research methods, create a training culture for the next generation of rehabilitation researchers and effectively implement proven cost effective interventions for Australians.
Osteosarcoma is the most common tumour of bone. Recent success in targeting immune checkpoint blockers such as Programmed death-1 (PD-1) in genomically complex tumours suggests that osteosarcomas may be amenable to such strategies. We will characterise the role of the PD-1 pathway in osteosarcoma development and growth. Using preclinical mouse models we will investigate the biology of the PD-1 pathway and study its potential as a therapeutic target in advanced and resectable osteosarcoma.
Promoting Independence Through Quality Dementia Care At Home (PITCH)
Funder
National Health and Medical Research Council
Funding Amount
$1,541,611.00
Summary
Many people with dementia live at home with support from both paid and unpaid carers. There are currently limited opportunities for carers of people with dementia to receive education and training in how to communicate, manage symptoms and deliver person-centred care. This project will develop and trial a education and training program for front-line home care workers that aims to improve quality of care and quality of life for people with dementia and their carers.
A Multi-centre RCT To Prevent Secondary Falls In Older People Presenting To The Emergency Department With A Fall
Funder
National Health and Medical Research Council
Funding Amount
$1,534,471.00
Summary
Falls are a leading cause for presentation to Emergency Departments (EDs) by older patients. More than 50% who present to ED with a fall injury have fallen in the previous year. RESPOND is an innovative post-ED discharge program designed to reduce secondary falls in older people. RESPOND extends current falls prevention research and practice by incorporating patient-centred education with behaviour change strategies proven to be effective in the secondary prevention of cardiovascular events.
Optimising Early Interventions For Young People With Emerging Mood Disorder
Funder
National Health and Medical Research Council
Funding Amount
$2,653,052.00
Summary
One of our greatest health challenges is to develop highly-personalised interventions for teenagers and young adults with emerging mood disorders, like major depression or bipolar disorder. This new Australian centre combines our national expertise and links it with research innovation and training in key European and North American centres. It tests the viability of selecting the best treatments for young people with mood disorders on the basis of novel genetic, neuropsychological, circadian, i ....One of our greatest health challenges is to develop highly-personalised interventions for teenagers and young adults with emerging mood disorders, like major depression or bipolar disorder. This new Australian centre combines our national expertise and links it with research innovation and training in key European and North American centres. It tests the viability of selecting the best treatments for young people with mood disorders on the basis of novel genetic, neuropsychological, circadian, imaging, immunological or clinical methods.Read moreRead less