Centre For Clinical Research Execllence In Infectous Diseases
Funder
National Health and Medical Research Council
Funding Amount
$2,000,000.00
Summary
The Centre will enhance Australia's capacity in patient oriented research in infectious disease, building on the strengths of the Victorian Infectious Diseases Service for improvement of patient outcomes and betterment of human health. They will strengthen programs in clinical virology, infections in immunocompromised hosts, infections of travellers and immigrants, computer assisted decision making and will fill an important gap in training and mentoring physicians for clinical research.
PRevention & Early Intervention In Mental Illness And Substance UsE (PREMISE CRE)
Funder
National Health and Medical Research Council
Funding Amount
$2,495,969.00
Summary
Substance use and mental disorders are among the leading causes of burden of disease in young people globally. Effective prevention and early intervention can reduce disease burden by halting, interrupting or delaying the onset and development of disorder. The PREMISE CRE will build the science to move the field from crisis, acute care and containment to prevention and early intervention, achieving a critical aim of the Australian Government’s program of reform in mental health and addiction.
Improving Translation Of Evidence Into Practice For Musculoskeletal Conditions
Funder
National Health and Medical Research Council
Funding Amount
$948,684.00
Summary
Musculoskeletal conditions place a huge burden on the world’s population. Yet current trials in this field may not reflect priorities based upon this burden and few trials address well-recognised evidence-practice gaps. My fellowship will aim to transform the current ad hoc approach to Australian musculoskeletal clinical trials. It will identify the most critical unanswered questions, formulate a national research agenda, and identify best methods for optimising uptake of findings into practice.
Nocturnin: A Post-transcriptional Regulator Of Circadian Fat Metabolism
Funder
National Health and Medical Research Council
Funding Amount
$574,696.00
Summary
Our metabolism is aligned with the 24-hour rotation of the earth in what is termed the circadian clock. Being misaligned to this clock explains jetlag and the poor health associated with shift-workers. For example, whether fat is utilised or stored depends on the time of day. This study aims to investigate the post-transcriptional mechanisms that underpin the rhythmic changes that occur throughout our bodies to ensure that our metabolism is matched to our environment.
Generating And Translating Evidence Into Practice In Womens Health And Beyond
Funder
National Health and Medical Research Council
Funding Amount
$501,659.00
Summary
Obesity is increasing with major reproductive and metabolic health impacts for women and the next generation. This fellowships focuses on prevention of obesity and optimal diagnosis and management of obesity related reproductive and metabolic conditions in women including before and during pregnancy. Translation is vital to deliver health benefits from research. Here Prof Teede will generate new evidence and translate this into practice in women’s health and beyond to deliver tangible impact.
UNDERSTANDING THE MOLECULAR MECHANISMS CONTROLLING NUCLEOLAR SURVEILLANCE IN DISEASE
Funder
National Health and Medical Research Council
Funding Amount
$855,972.00
Summary
Alterations in the ability of cells to make ribosomes, the cellular factories that make protein, contribute to a range of diseases including cancer and a class of inherited disorders called ribosomopathies that are rare but largely untreatable. These changes cause disease by controlling the “nucleolar surveillance pathway” that causes cells to either stop dividing or die. Here we propose to identify new genes that regulate this pathway to identify new targets for treating these diseases.