The Role Of B7 Family Members In The Generation Of Immunological Memory
Funder
National Health and Medical Research Council
Funding Amount
$437,252.00
Summary
Memory immune cells remember antigens that have previously induced an immune response. Therefore, they can react quickly and rigorously to stop subsequent infections. This project will study the role of the B7 family of proteins in communication between memory cells and other cells of the immune system to produce lifetime protection against foreign antigens. Understanding these processes will assist in creating more effective vaccines and treatments for immunodeficient or autoimmune patients.
Role Of The Novel G Protein-coupled Receptor EBI2 In B And T Cell Responses
Funder
National Health and Medical Research Council
Funding Amount
$304,815.00
Summary
The ability of the immune system to fight infections relies on the capacity of immune cells to traffic within immune organs in order to encounter invading pathogens and to interact with each other. Cells are guided in their migration by “homing receptors”, which recognize localization signals. This study aims at understanding the role of a novel member of this class of receptors, Epstein-Barr virus-induced gene 2 (EBI2), in the immune system and in protection against infectious microorganisms.
The Role Of Nalp1 In Autoimmune Disease And Innate Immune Defense As Determined By Murine Genetic Deletion.
Funder
National Health and Medical Research Council
Funding Amount
$320,237.00
Summary
The innate immune system is a critical barrier against invading microorganisms, however when improperly regulated it can lead to autoimmune disease. Nalp1 is a protein that is important for innate immune recognition of anthrax infection, and is also involved in susceptibility to vitiligo and associated autoimmune diseases. This project seeks to create mice that are deficient for the gene encoding Nalp1 so as to further study the role of this protein in innate immune defense and autoimmunity.