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Is Mitochondiral STAT3 Necessary For K-Ras Induced Myeloid Leukaemias?
Funder
National Health and Medical Research Council
Funding Amount
$425,326.00
Summary
Myeloid leukaemia (ML) is a family of diseases characterized by the expansion of white blood cells, leading to death from haematopoietic complications. One common mutation that gives a proliferative advantage in ML is in the Ras oncogenes. We recently showed that signal transducer and activator of transcription 3 (STAT3) is necessary for the transforming potential of Ras due to its ability to support the metabolic changes necessary for tumour growth. This research will characterize the STAT3-dep ....Myeloid leukaemia (ML) is a family of diseases characterized by the expansion of white blood cells, leading to death from haematopoietic complications. One common mutation that gives a proliferative advantage in ML is in the Ras oncogenes. We recently showed that signal transducer and activator of transcription 3 (STAT3) is necessary for the transforming potential of Ras due to its ability to support the metabolic changes necessary for tumour growth. This research will characterize the STAT3-dependent metabolic changes in ML.Read moreRead less
Wbp2, A New Regulator Of The Hippo Tumor Suppressor Pathway
Funder
National Health and Medical Research Council
Funding Amount
$585,860.00
Summary
The Hippo pathway is a key regulator of tissue growth. It was first discovered in vinegar flies and plays a similar role in mammals. We aim to define the mechanism by which a newly-identified Hippo pathway protein, Wbp2, functions to control growth. These studies will be performed in flies and confirmed in mammalian cells. Ultimately, our studies will shed light on how tissue growth is controlled, and have the potential to inform the way that we treat human cancers and tissue growth disorders.
Identification Of Novel Tumour Suppressors In Ras-mediated Tumourigenesis
Funder
National Health and Medical Research Council
Funding Amount
$580,504.00
Summary
Cancer is a cooperative process, involving mutations in several genes. Activation of the signaling protein, Ras, contributes to ~30% of human cancers, but alone is not sufficient for tumour formation. The identification of cooperating Tumour Suppressors (TSs), and their analysis in the vinegar fly, Drosophila, mammalian cells and mouse models is key to understanding cancer progression and for the development of therapeutic regimes
Targeting Of The Myb-p300 Interaction In Myeloid Leukaemogenesis
Funder
National Health and Medical Research Council
Funding Amount
$625,980.00
Summary
MYB is a “cancer gene” which turns other genes on or off. MYB is needed by leukaemia cells but also for normal blood cell formation. This project aims to show that blocking interaction between the MYB protein and another protein called p300 is a promising strategy for leukaemia treatment, as leukaemia cells are more dependent on this interaction than normal cells. New molecules to block the MYB-p300 interaction will also be designed and tested; these may form a basis for new leukaemia drugs.
Cancer is constantly being suppressed in our bodies by a process that stops damaged cells from growing: 'senescence'. The mechanism that translates the damage stimuli into this state of permanent cell arrest is only partially known. We have identified a protein that appears to drive this restraint. The possibility of manipulating this process to prevent and cure cancer makes it in important target to study.
Genetic Fate Mapping Of Mesenchymal Stem Cell Origins And Investigating Their Contribution To Developmental Haematopoiesis
Funder
National Health and Medical Research Council
Funding Amount
$611,525.00
Summary
Mesenchymal stem cells are a population of cells that reside in various organs in the body and are thought to contribute to tissue repair. However little is known about the developmental origins and identity of these cells. I will investigate where these cells originate from, their molecular identity and how they relate to blood development. These findings will help in developing protocols to manipulate these cells to repair damaged organs. This study will also inform current attempts to generat ....Mesenchymal stem cells are a population of cells that reside in various organs in the body and are thought to contribute to tissue repair. However little is known about the developmental origins and identity of these cells. I will investigate where these cells originate from, their molecular identity and how they relate to blood development. These findings will help in developing protocols to manipulate these cells to repair damaged organs. This study will also inform current attempts to generate blood stem cells.Read moreRead less
Development And Valuation Of Cancer-specific Multi-attribute Health States For Use In Economic Evaluation
Funder
National Health and Medical Research Council
Funding Amount
$707,671.00
Summary
Economic evaluation is used by the Australian government in deciding which medical services and pharmaceuticals should be funded. This study will develop quality of life utility measures for use in economic evaluation of cancer interventions in Australia and internationally. This represents a significant methodological contribution to the assessment of quality of life, effectiveness and efficiency in cancer, in one of Australia's national health priority areas.
Defining Epigenetic Predictors Of Long-term Outcomes Of Preterm Birth
Funder
National Health and Medical Research Council
Funding Amount
$409,408.00
Summary
On average, those born premature do worse health-wise than those born at term. However, some do worse than others. Our aim is to identify these people at birth to better help doctors and parents to closely monitor their health. For this, we will be “reading the diary of pregnancy” in the molecules added to chromosomes in blood during pregnancy in young adults with will characterised states of health. We will analyse DNA from blood that we will extract from stored heel prick spots.
Investigating Causes Of Stillbirths: A Prospective Cohort Study Examining Use And Effectiveness Of A Comprehensive Investigation Protocol
Funder
National Health and Medical Research Council
Funding Amount
$567,508.00
Summary
The effects of stillbirth on women and their families are often devastating and long term. Many stillbirths are not appropriately investigated, resulting in lack of accurate data on causes with one-third classified as unexplained. A major driver for suboptimal investigation is the lack of research to guide which tests should be done. This study aims to accurately identify causes of death in 984 comprehensively investigated stillbirths and determine which tests are needed, with consideration of c ....The effects of stillbirth on women and their families are often devastating and long term. Many stillbirths are not appropriately investigated, resulting in lack of accurate data on causes with one-third classified as unexplained. A major driver for suboptimal investigation is the lack of research to guide which tests should be done. This study aims to accurately identify causes of death in 984 comprehensively investigated stillbirths and determine which tests are needed, with consideration of costs and value.Read moreRead less
A Phase II Trial Of Follow-up Of Men With Prostate Cancer In Primary Care.
Funder
National Health and Medical Research Council
Funding Amount
$584,465.00
Summary
This study aims to develop and test a novel model of shared care for the follow-up of men with prostate cancer. Men treated for prostate cancer experience distressing and ongoing side-effects of treatment and significant psychological issues. Current models of care fail to address adequately these issues. The new model is designed to improve the care received and therefore the quality of life of men after treatment for prostate cancer.