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Field of Research : Bioinformatics and computational biology
Research Topic : Transcriptomics
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Bioinformatics and computational biology (3)
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  • Active Funded Activity

    Discovery Projects - Grant ID: DP230100941

    Funder
    Australian Research Council
    Funding Amount
    $448,456.00
    Summary
    Genome evolution & adaptation of the multinuclear wheat stripe rust fungus. Animals and plants package their genomes into a single nucleus within each cell. In contrast, millions of fungal species accommodate multiple nuclei containing individual haploid genomes. It is currently unknown what the evolutionary implications are for this unusual genome division into multiple nuclei. Here we explore the evolutionary consequences of genome division into multiple nuclei for the first time by applying c .... Genome evolution & adaptation of the multinuclear wheat stripe rust fungus. Animals and plants package their genomes into a single nucleus within each cell. In contrast, millions of fungal species accommodate multiple nuclei containing individual haploid genomes. It is currently unknown what the evolutionary implications are for this unusual genome division into multiple nuclei. Here we explore the evolutionary consequences of genome division into multiple nuclei for the first time by applying cutting edge genome biology tools and algorithms. The economically significant study system is the devastating wheat stripe rust fungus. This pathogen costs Australian farmers over $100 million a year. New understanding is expected to lead to better disease management, reduced fungicide applications, and increased yields.
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    Active Funded Activity

    Early Career Industry Fellowships - Grant ID: IE230100263

    Funder
    Australian Research Council
    Funding Amount
    $477,037.00
    Summary
    Improve genomic testing tools for fertility traits in beef cattle. Fertility is a key driver of productivity and profitability for beef industry; however, a substantial industry challenge is poor fertility and the difficulty and expense of measuring fertility in remote Australia. By integrating multiple omics datasets and fifty thousand fertility phenotypes recorded on beef cattle, the project will identify sequence variation, including structural variants, that underpin genetic variation in cat .... Improve genomic testing tools for fertility traits in beef cattle. Fertility is a key driver of productivity and profitability for beef industry; however, a substantial industry challenge is poor fertility and the difficulty and expense of measuring fertility in remote Australia. By integrating multiple omics datasets and fifty thousand fertility phenotypes recorded on beef cattle, the project will identify sequence variation, including structural variants, that underpin genetic variation in cattle fertility. Our industry partner, which genotypes hundreds of thousands of cattle a year, will produce new genotype arrays and novel low-cost sequencing approaches including these variants, enabling selection that could potentially increase herd reproductive rate by 4%, returning $40M per annum to the farmers.
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    Active Funded Activity

    Early Career Industry Fellowships - Grant ID: IE230100040

    Funder
    Australian Research Council
    Funding Amount
    $447,127.00
    Summary
    Unravelling the genetics of Kangaroo paws for climate-resilient gardens. The project will produce the first DNA-anchored plant lineage map of Kangaroo paws and gain novel insights into their resilient growth characteristics. Using novel genome and data-driven strategies, this project addresses the knowledge gap around the genetic heirloom of more than 200 iconic Kangaroo paw varieties to speed up the breeding of new varieties with enticing leaf patterns and flower colour combinations. While unra .... Unravelling the genetics of Kangaroo paws for climate-resilient gardens. The project will produce the first DNA-anchored plant lineage map of Kangaroo paws and gain novel insights into their resilient growth characteristics. Using novel genome and data-driven strategies, this project addresses the knowledge gap around the genetic heirloom of more than 200 iconic Kangaroo paw varieties to speed up the breeding of new varieties with enticing leaf patterns and flower colour combinations. While unravelling the inheritability and breeding barriers, immediate industry adoption will boost horticultural breeding programs long-term. This project uses cutting-edge science to enhance industry capacity for providing new Kangaroo paws for climate-resilient urban green spaces on the national and international market.
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