Harnessing The Power Of Single Cell Sequencing To Advance Biomedical Research
Funder
National Health and Medical Research Council
Funding Amount
$2,013,220.00
Summary
Our ability to sequence the DNA code has advanced rapidly in the last 10 years but this data is large and complex and we need advanced computational and statistical methods to analyse these data. Now we are able to generate this data from individual cells. I will provide the analysis approached that are required in order to use this data to understand the complexity of tissues at a cellular resolution. This will provide deep molecular insights into development and disease.
Appropriate growth of organs is essential for life and can go awry in diseases such as cancer. A crucial regulator of organ size and cancer that I co-discovered is the Hippo pathway. I aim to understand how this pathway relays information and controls gene expression to regulate organ size, and its role in mesothelioma and other human cancers. A better understanding of Hippo’s role in organ growth and cancer will allow it to be targeted for therapeutic benefit in human diseases.