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Direct substitution acyl azolium catalysis: new approaches in reaction discovery. New chemical reactions play a central role in the creation of new materials and knowledge for society. This project will develop new catalytic reactions that create useful materials in a rapid and efficient fashion without creating an excessive drain on resources.
Expanding the organometallic toolbox for constructing heterocycles. This project aims to design and synthesise stereospecific cyclic molecules. This is a problem for chemists, particularly when bioactivity and medicinal relevance depend on complex stereochemistry and substitution patterns. This team will build on their discovery of a cascade reaction for synthesising highly stereospecific indolene derivatives. They will target reagents and reaction pathways for creating heterocyclic molecules wh ....Expanding the organometallic toolbox for constructing heterocycles. This project aims to design and synthesise stereospecific cyclic molecules. This is a problem for chemists, particularly when bioactivity and medicinal relevance depend on complex stereochemistry and substitution patterns. This team will build on their discovery of a cascade reaction for synthesising highly stereospecific indolene derivatives. They will target reagents and reaction pathways for creating heterocyclic molecules which are difficult to access. They will synthesise and characterise homo- and hetero-bimetallic complexes to develop cyclic molecules and scaffolds relevant in drug discovery. New molecules and reaction pathways will be relevant for biological and medicinal chemistry, and drug discovery programmes.Read moreRead less
Synthesis, Synergy and Sustainability: Development of active-metal reagents. The design and realisation of new and important molecules requires innovative and efficient methods. This project will create a new store of active-metal molecular tools for the selective, catalytic and atom efficient construction of a diverse library of phosphorus heterocyclic scaffolds and chemical feedstocks relevant to biological, medicinal, and materials chemistry, and the fine chemical industry. Parallel studies e ....Synthesis, Synergy and Sustainability: Development of active-metal reagents. The design and realisation of new and important molecules requires innovative and efficient methods. This project will create a new store of active-metal molecular tools for the selective, catalytic and atom efficient construction of a diverse library of phosphorus heterocyclic scaffolds and chemical feedstocks relevant to biological, medicinal, and materials chemistry, and the fine chemical industry. Parallel studies employing environmentally friendly and benign deep eutectic solvents will allow for replacement of traditional hazardous volatile organic solvents, putting the newly created active-metal reagents at the forefront of the necessary shift towards a more sustainable and 'green' polar organometallic chemistry. Read moreRead less
Early main group organometallic complexes and their role in asymmetric synthesis. This project will develop new highly reactive metal based molecular tools for the controlled synthesis of complex molecules which are normally difficult to access, and in so doing advances our synthetic armoury. The design of the reaction pathways and final molecules will have relevance for modern medicinal chemistry and drug discovery programs.
Compressing small peptides for cell absorption. This project aims to understand how to make small structured peptides cell-permeable. Short peptides matching bioactive protein surfaces have no structure in water and do not enter cells, where most biological reactions occur. This project will compress peptides into very small coiled structures and systematically vary cyclic restraints, physicochemical properties and location of components to increase cell uptake by different mechanisms. An expect ....Compressing small peptides for cell absorption. This project aims to understand how to make small structured peptides cell-permeable. Short peptides matching bioactive protein surfaces have no structure in water and do not enter cells, where most biological reactions occur. This project will compress peptides into very small coiled structures and systematically vary cyclic restraints, physicochemical properties and location of components to increase cell uptake by different mechanisms. An expected outcome is new knowledge for predicting structures that make peptides cell-permeable without membrane damage. A new capacity to rationally downsize proteins to small, cell-permeable, structured peptides is anticipated to permit many new biological and industrial applications.Read moreRead less
Engineering Cyclic Peptides For Oral Bioavailability. The 21st century has become the age of injectable peptide therapeutics. To fully realise their benefits , peptide drugs need to become smaller, cheaper and orally deliverable. Proteins often exhibit potent and selective biological actions through small peptide surfaces. These surfaces have been mimicked in cyclic peptides that are similarly potent and selective. However, cyclic peptides do not have the right properties to be oral drugs. This ....Engineering Cyclic Peptides For Oral Bioavailability. The 21st century has become the age of injectable peptide therapeutics. To fully realise their benefits , peptide drugs need to become smaller, cheaper and orally deliverable. Proteins often exhibit potent and selective biological actions through small peptide surfaces. These surfaces have been mimicked in cyclic peptides that are similarly potent and selective. However, cyclic peptides do not have the right properties to be oral drugs. This project aims to re-engineer their surfaces to survive potential degradation in the gut, to permeate membranes and to withstand clearance from blood. The projected outcome of this project is new information and technology for downsizing proteins to small orally bioavailable peptides for therapeutic applications.Read moreRead less
Turning homogeneous catalysts into heterogeneous catalysts: Robust linking of organometallic complexes onto inert carbon supports. Improvement in the sustainability of fine chemical synthesis is urgently required to meet the increasing demand for new pharmaceuticals. This project will develop new approaches to catalyst immobilisation, to enhance catalyst recovery, as well as to the characterisation of such catalysts for understanding structure and mechanism.
Molecular magnetic materials of the cluster and network types. This research project involves the preparation of new molecular based magnets, using metals such as manganese or dysprosium, together with detailed studies of their physical properties. When groups of these metal ions form in to clusters, bridged by organic molecules, they are nano-sized and display new and useful magnetic and quantum properties.
ARC Centre of Excellence in Advanced Molecular Imaging. The Centre of Excellence in Advanced Molecular Imaging will innovatively integrate physics, chemistry and biology to unravel the complex molecular interactions that define immunity. The Centre will develop new imaging methods to visualize atomic, molecular and cellular details of how immune proteins interact and
effect immune responses. Outcomes: (i) new technological innovations leading to new imaging methods and products; and (ii) fundame ....ARC Centre of Excellence in Advanced Molecular Imaging. The Centre of Excellence in Advanced Molecular Imaging will innovatively integrate physics, chemistry and biology to unravel the complex molecular interactions that define immunity. The Centre will develop new imaging methods to visualize atomic, molecular and cellular details of how immune proteins interact and
effect immune responses. Outcomes: (i) new technological innovations leading to new imaging methods and products; and (ii) fundamental advances in understanding details of immune responses in health and disease. The Centre will enable Australia to be an international leader in biological imaging, to train next
generation interdisciplinary scientists, and to provide new insights for combating common diseases that afflict society.Read moreRead less