BRAIN Training Trial: Balance, Resistance, Or INterval Training Trial: A Randomised Controlled Trial Of Three Exercise Modalities In Mild Cognitive Impairment
Funder
National Health and Medical Research Council
Funding Amount
$2,016,192.00
Summary
About 10% of older adults have mild changes in memory or thinking (Mild Cognitive Impairment, or MCI) which don’t interfere with daily life, but increase the risk of dementia. Exercise may improve thinking abilities, but the best kind of exercise is not clear. We will randomise 530 older adults with MCI in Australia, Canada, and Israel to weight lifting, high intensity aerobic training or toning exercises for 12 months to see which prescription is best for brain health and overall function.
Organizational Change And Treatment Of Depression And Dementia In Aged Care Facilities
Funder
National Health and Medical Research Council
Funding Amount
$567,052.00
Summary
Mental health disorders are common in aged care settings. However, these problems are not well managed. This situation results in distress for residents and family members, as well as high levels of burnout and turnover among staff. This project will address the organizational barriers with the aim of better managing and treating depression and behavioural problems associated with dementia.
AVERT-DOSE (Determining Optimal Early Rehabilitation After StrokE): A Multi-arm Covariate-adjusted, Response-adaptive Randomised Controlled Trial
Funder
National Health and Medical Research Council
Funding Amount
$4,359,564.00
Summary
AVERT-DOSE is an international, investigator-led clinical trial, developed in Australia but recruiting >2500 patients from 6 countries around the world. In this trial we will establish the optimal model of early mobility rehabilitation for people with acute stroke. The protocols we develop will be suitable for adoption in clinical practice in developed and developing countries and help reduce the unacceptably high personal and community burden of stroke-related disability world wide.
A Phase Two Clinical Trial Of A Program Delivered By Aboriginal Health Workers To Prevent Early Childhood Caries In Aboriginal Children.
Funder
National Health and Medical Research Council
Funding Amount
$553,905.00
Summary
The severe impact of early childhood dental caries on Aboriginal children highlights the need for the development of evidence-based community oral health strategies which are appropriate to the needs and resources of Aboriginal families and their health care services. This study responds to this need through the evaluation of a family centred oral health strategy developed in consultation with Aboriginal Community Controlled Health Services which is delivered by Aboriginal Health Workers.
A Randomised Controlled Trial Of Cognitive-only And Cognitive-motor Training To Prevent Falls In Older People: Understanding Physical, Neuropsychological And Neural Mechanisms
Funder
National Health and Medical Research Council
Funding Amount
$1,624,934.00
Summary
The rate of falls in older people remains a significant problem. We have developed and validated a home-based computerised training intervention that can be delivered either while seated (cognitive) or while standing and undertaking balance exercises (cognitive+motor). This unique design will allow us to assess whether cognitive and cognitive+motor training can prevent falls, as well as the neural, physiological, physical and neuropsychological mechanisms behind the intervention effects.
Evaluating “Standing Tall” – An Engaging Home-based Exercise Program Using Mobile Technology For Maximizing Long-term Adherence And Preventing Falls In Older People: Randomized Controlled Trial
Funder
National Health and Medical Research Council
Funding Amount
$791,081.00
Summary
Current evidence suggests that older people have to exercise for two hours per week for six months to prevent falls, with a strong focus on balance exercises. We have developed and tested an engaging home-based balance training program delivered through mobile (tablet) technology, called ‘Standing Tall’. We propose a randomised controlled trial to examine the effectiveness of our program for preventing falls in 500 community-dwelling older people, in addition to adherence- and cost-analyses.
Does Manipulation Of Arterial Shear Stress Enhance Cerebrovascular Function And Cognition In The Aging Brain?
Funder
National Health and Medical Research Council
Funding Amount
$707,914.00
Summary
Globally, 9.2 million less cases of dementia could result from delaying it by as little as 12 months. We will assess the impact, on artery health and cognition, of a novel exercise intervention involving enhanced patterns of brain blood flow and arterial shear stress during exercise, stimuli which should optimise cerebrovascular health. Given that pharmacological approaches to prevention are ineffective, this project has the potential to address the future impact of this common and debilitating ....Globally, 9.2 million less cases of dementia could result from delaying it by as little as 12 months. We will assess the impact, on artery health and cognition, of a novel exercise intervention involving enhanced patterns of brain blood flow and arterial shear stress during exercise, stimuli which should optimise cerebrovascular health. Given that pharmacological approaches to prevention are ineffective, this project has the potential to address the future impact of this common and debilitating disease in Australians.Read moreRead less
AVERT: A Large, International, Randomised Controlled Trial Testing Efficacy And Cost Effectiveness Of Early And Frequent Mobilisation After Stroke
Funder
National Health and Medical Research Council
Funding Amount
$2,020,623.00
Summary
AVERT is a large, international clinical trial that tests whether introducing early and frequent exercise helps reduce the unacceptably high burden of death and disability associated with stroke. We are also testing if the intervention is cost effective. This trial will provide reliable evidence to guide clinical practice. If positive, broad implementation in both developed and developing countries is likely, thus helping to reduce the global burden of stroke related death and disability.
A Novel, Technology-based Program Targeting Physical, Cognitive And Mental Well-being To Maximise Fall Prevention In Older People: An Evidence-based Multifactorial Approach
Funder
National Health and Medical Research Council
Funding Amount
$1,475,781.00
Summary
Accidental falling among older people is a significant public health challenge worldwide. This study addresses a key gap in the translation of available evidence to prevent falls in older people more effectively. The proposed trial will provide the first-ever evidence about the cost and effectiveness of a tailored multifactorial fall prevention program using technology and self-management principles.
Preventing Falls In Older People With Dementia - A Randomised Controlled Trial
Funder
National Health and Medical Research Council
Funding Amount
$1,349,410.00
Summary
There is no evidence to date that has shown it is possible to prevent falls in older people with dementia. This proposal builds on a number of years of research by this group to try and address the question of how to prevent falls in people with dementia. We will undertake a study looking at the impact of a professionally prescribed, carer assisted, individualised exercise and home hazard reduction program on falls in people with dementia.