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Tooth wear is a significant clinical problem for both older people who have kept their natural teeth and for some younger individuals. The main causes of tooth wear are attrition (resulting from tooth to tooth contact), abrasion (from dietary and environmental abrasives) and erosion (caused by acidic food and drinks or from regurgitation of acid). At present our understanding of the relative significance of these types of wear and the exact conditions under which excessive wear occurs is limited ....Tooth wear is a significant clinical problem for both older people who have kept their natural teeth and for some younger individuals. The main causes of tooth wear are attrition (resulting from tooth to tooth contact), abrasion (from dietary and environmental abrasives) and erosion (caused by acidic food and drinks or from regurgitation of acid). At present our understanding of the relative significance of these types of wear and the exact conditions under which excessive wear occurs is limited. Furthermore our understanding of the wear characteristics of many commonly used dental materials is limited. The proposed study will provide important new information about: the interaction between applied bite forces and acids in the oral environment as determinants of the rate of tooth wear; the potential for wear prevention using mouth rinses and gels; the wear characteristics of dental materials commonly used to restore teeth.Read moreRead less
Probing Developmental Causes Of Soft Tooth Enamel With Novel Mouse Models
Funder
National Health and Medical Research Council
Funding Amount
$470,112.00
Summary
Tooth decay is one of the most costly diseases in Australia and was recently called a national tragedy by the Prime Minister. The risk of decay increases if teeth don't harden properly in childhood. This project aims to clarify the causes of soft enamel and identify ways to prevent it. Two new test systems will be used to see how antibiotics and fluoride affect enamel hardening. Our findings will help the battle against tooth decay and guide the safe use of medicines in children.
Molecular Studies Of Dentine Phosphophoryn And Development Of A Biomimetic Dental Restorative Material.
Funder
National Health and Medical Research Council
Funding Amount
$444,750.00
Summary
This project involves the study of a protein that is found in teeth and is responsible for the development of dentine. The project involves characterisation of this protein and its interaction with calcium phosphate mineral using a variety of techniques. The information obtained will allow the synthesis of a peptide that will mimick the function of phosphophoryn. This peptide will be used together with stabilized amorphous calcium phosphate in a novel dental restorative material that will help p ....This project involves the study of a protein that is found in teeth and is responsible for the development of dentine. The project involves characterisation of this protein and its interaction with calcium phosphate mineral using a variety of techniques. The information obtained will allow the synthesis of a peptide that will mimick the function of phosphophoryn. This peptide will be used together with stabilized amorphous calcium phosphate in a novel dental restorative material that will help protect the surrounding tooth tissue.The outcome will be an improved understanding of the design principles used by nature to engineer teeth. The significance is the potential development of biocompatible, superior dental restorative materials.Read moreRead less
Characterisation Of Proteins Involved In Biomineralisation Processes
Funder
National Health and Medical Research Council
Funding Amount
$234,175.00
Summary
This project involves the study of two proteins that associate with calcium and phosphate. Phosphophoryn is found in teeth and is responsible for the development of dentine in teeth. Osteopontin is a multi-functional protein found in a variety of tissues as well as in bone and in milk. Its functions in bone and milk are unknown although it is believed to be involved in bone remodelling. This project involves characterisation of these two proteins and their interactions with calcium phosphate min ....This project involves the study of two proteins that associate with calcium and phosphate. Phosphophoryn is found in teeth and is responsible for the development of dentine in teeth. Osteopontin is a multi-functional protein found in a variety of tissues as well as in bone and in milk. Its functions in bone and milk are unknown although it is believed to be involved in bone remodelling. This project involves characterisation of these two proteins and their interactions with calcium phosphate mineral using a variety of techniques. The outcome will be an improved understanding of the design principles used by nature to engineer teeth and bone. The significance is the potential development of biocompatible apatite-based biomaterials for both tooth and bone.Read moreRead less
Characterization Of Casein Phosphopeptide Amorphous Calcium Fluoride Phosphate As A Remineralization System
Funder
National Health and Medical Research Council
Funding Amount
$493,514.00
Summary
Dental caries (tooth decay) remains a major public health problem in Australia with an economic burden in excess of $1 billion p.a. The overall aim of this project is the development of a novel remineralizing agent (casein phosphopeptide stabilized amorphous calcium fluoride phosphate) for the remineralization of early tooth decay lesions (white spot lesions). The project will involve the testing of the ability of the novel remineralization system to remineralize (repair) white spot lesions in v ....Dental caries (tooth decay) remains a major public health problem in Australia with an economic burden in excess of $1 billion p.a. The overall aim of this project is the development of a novel remineralizing agent (casein phosphopeptide stabilized amorphous calcium fluoride phosphate) for the remineralization of early tooth decay lesions (white spot lesions). The project will involve the testing of the ability of the novel remineralization system to remineralize (repair) white spot lesions in vitro and in situ. The project also involves the detailed characterization of the molecular interactions of the components of the remineralizing system using NMR spectroscopy and other techniques. It is anticipated that this project will result in the development of a system with substantialy superior properties for the non-invasive treatment (reversal) of white spot lesions and may ultimately lead to the development of a novel system for the treatment and prevention of tooth decay.Read moreRead less
Enhanced Enamel Remineralisation With CPP-ACP And Fluoride
Funder
National Health and Medical Research Council
Funding Amount
$668,074.00
Summary
Tooth decay remains a major public health problem. The project will involve the testing of the system to remineralize (repair) early stages of decay in the laboratory. The project also involves the detailed characterization of the molecular interactions of the components of a system. It is anticipated that this project will result in the development of a system with substantialy superior properties for the non-invasive treatment (repair) of early tooth decay.
A Clinical And Experimental Study Of The Biomechanical Factors Associated With Tooth Destruction
Funder
National Health and Medical Research Council
Funding Amount
$241,527.00
Summary
This project investigates the influence of biting force on the development of non-carious and carious defects of teeth. Strain gauges will be cemented to the neck region of extracted teeth and teeth in the mouth, forces applied to the biting surfaces of the teeth, and the stress which results will be measured by the strain gauge. A profiling technique and high-power microscopy will be used to determine the amount of tooth structure lost as a result of applying the forces in the presence of acid. ....This project investigates the influence of biting force on the development of non-carious and carious defects of teeth. Strain gauges will be cemented to the neck region of extracted teeth and teeth in the mouth, forces applied to the biting surfaces of the teeth, and the stress which results will be measured by the strain gauge. A profiling technique and high-power microscopy will be used to determine the amount of tooth structure lost as a result of applying the forces in the presence of acid. In addition, a computer model will be generated, to determine whether it can be used to predict the stresses. In a clinical study, patients with and without non-carious defects will be followed for three years in order to assess the morphological changes and measure the volume loss of tooth structure which occurs.Read moreRead less