This program will investigate the strategies used by pathogenic bacteria to cause human diseases. The research will focus on how bacteria initiate infections, how they invade, cause cell and tissue damage and respond to their human host. It will also examine how the host’s innate immune system interacts with these bacteria. The results will provide new insights into host-pathogen interactions and reveal new targets for the development of novel antibacterial drugs and vaccines.
Sociophysical Interactions: understanding the role of social and tangible technologies in maintaining good habits into old age. How can technology help us 'age well'? The project will study, design and evaluate novel information systems that integrate and support social engagement and physical activity in order to build foundational knowledge about these technologies and maintain the opportunities for social engagement and physical activity in our ageing population.
Sonification for complex, mission-critical work environments. Human operators must often pay attention to an immediate task while monitoring background information, but intrusive alarms often capture operators' attention inappropriately. We investigate how continuous auditory information ("sonification") can provide low-level background information when all is normal, yet capture attention to abnormalities only when needed. The results of three experiments will determine the most effective combi ....Sonification for complex, mission-critical work environments. Human operators must often pay attention to an immediate task while monitoring background information, but intrusive alarms often capture operators' attention inappropriately. We investigate how continuous auditory information ("sonification") can provide low-level background information when all is normal, yet capture attention to abnormalities only when needed. The results of three experiments will determine the most effective combination of visual and auditory information delivery; how well sonification captures attention when needed; and whether sonification captures attention to deviations from expected changes. Our findings will help establish principles of attentional mapping that significantly extend current approaches to interactive systems design.Read moreRead less
Enhancing the content and experience of Interactive Childrens Television. Interactive television (iTV) as a participatory, on-demand communication provides a unique opportunity to significantly engage, entertain and educate preschool children. Through considerable industry partner collaboration and participation, this project will evaluate three distinct interactive options produced from selected children's television programs with proven success in Australia. Usability studies employing a vari ....Enhancing the content and experience of Interactive Childrens Television. Interactive television (iTV) as a participatory, on-demand communication provides a unique opportunity to significantly engage, entertain and educate preschool children. Through considerable industry partner collaboration and participation, this project will evaluate three distinct interactive options produced from selected children's television programs with proven success in Australia. Usability studies employing a variety of surveillance techniques will evaluate content design and user response. Children's viewing habits will be evaluated within a social context (the home) and a mobile lab setting using qualitative and quantitative assessment. The results will identify effective ways to produce meaningful interactivity and will encourage future industry based research.Read moreRead less
Understanding the differentiation of the endocardium. The project aims to understand the genetic regulation of endocardial development. The heart is essential for survival, its beat the indicator of life. The endocardium, the heart’s inner lining, is required for signalling during heart development and is a major component of the valves, septa and trabeculae. Despite its indispensable role, little is known about how it forms or develops. This project integrates two complementary approaches that ....Understanding the differentiation of the endocardium. The project aims to understand the genetic regulation of endocardial development. The heart is essential for survival, its beat the indicator of life. The endocardium, the heart’s inner lining, is required for signalling during heart development and is a major component of the valves, septa and trabeculae. Despite its indispensable role, little is known about how it forms or develops. This project integrates two complementary approaches that have identified the earliest marker of endocardial differentiation and devised the method to make endocardium from stem cells. Knowledge from this work will inform future research into growing and regenerating damaged tissue.Read moreRead less
Minimising the inappropriate and unnecessary hospital admissions of frail older people. The health system will continue to experience massive pressures in both fiscal and human resource terms. Older patients present with multiple, complex conditions and tend to be admitted because clinicians often do not have the time to explore other options. This project will develop and evaluate a unique and robust model for minimising inappropriate hospital admissions through rapid assessment of suitability ....Minimising the inappropriate and unnecessary hospital admissions of frail older people. The health system will continue to experience massive pressures in both fiscal and human resource terms. Older patients present with multiple, complex conditions and tend to be admitted because clinicians often do not have the time to explore other options. This project will develop and evaluate a unique and robust model for minimising inappropriate hospital admissions through rapid assessment of suitability for home care and complete referral information for safety and quality. Read moreRead less
Kruppel-like factors and the methylome. This project aims to test the hypothesis that the KLF/SP family of transcription factors work in part via dynamic interactions with methylated cytosine nucleotides in DNA. This is fundamental to their function as pioneer factors in reprograming and their ability to co-ordinate differentiation and organogenesis. Conversely, dynamic changes in methylation status engage or disengage new regulatory elements in the genome via recruitment of KLF/SP family protei ....Kruppel-like factors and the methylome. This project aims to test the hypothesis that the KLF/SP family of transcription factors work in part via dynamic interactions with methylated cytosine nucleotides in DNA. This is fundamental to their function as pioneer factors in reprograming and their ability to co-ordinate differentiation and organogenesis. Conversely, dynamic changes in methylation status engage or disengage new regulatory elements in the genome via recruitment of KLF/SP family proteins as specific effectors. This project will address a new paradigm in genetics that is likely to underpin development.Read moreRead less
Controlling the adhesome to regulate cell fate on biomaterials. Mesenchymal stem cell-based tissue engineering practices are hampered worldwide by the lack of appreciation and understanding of the matrix-mediated cues that must be provided during adhesion and spreading to drive cells to definitive tissue end points. This project will address these knowledge deficiencies by combining high throughput array technologies, a set of tailorable self-assembling biomaterials and real-time biosensors to r ....Controlling the adhesome to regulate cell fate on biomaterials. Mesenchymal stem cell-based tissue engineering practices are hampered worldwide by the lack of appreciation and understanding of the matrix-mediated cues that must be provided during adhesion and spreading to drive cells to definitive tissue end points. This project will address these knowledge deficiencies by combining high throughput array technologies, a set of tailorable self-assembling biomaterials and real-time biosensors to rapidly, at high resolution, elucidate how mechanotransductive cues determine the fate choice of mesenchymal stem cells, and furthermore, how to manipulate them with smart biomaterial design to achieve desired outcomes for tissue engineering. Read moreRead less
Bone tissue engineering using innovative tubular dual-layered nanofiber meshes. Lifetime risks for long-bone fractures in Caucasians over the age of 50 are 17 per cent for women and 6 per cent for men. A clear therapeutic need exists to address the ever-increasing problems of diminished productivity and reduced quality of life associated with bone disorders as the population ages. To address this challenge, the project’s multidisciplinary, international team will develop technologies to heal tib ....Bone tissue engineering using innovative tubular dual-layered nanofiber meshes. Lifetime risks for long-bone fractures in Caucasians over the age of 50 are 17 per cent for women and 6 per cent for men. A clear therapeutic need exists to address the ever-increasing problems of diminished productivity and reduced quality of life associated with bone disorders as the population ages. To address this challenge, the project’s multidisciplinary, international team will develop technologies to heal tibial defects. Furthermore, it will establish Australia's prominence in the tissue engineering field, training the next generation of young scientists and engineers. This technology will be of interest to numerous research groups and companies worldwide and will foster international collaboration, placing Australia at the forefront of this emerging field.Read moreRead less
Special Research Initiatives - Grant ID: SR1101002
Funder
Australian Research Council
Funding Amount
$21,000,000.00
Summary
Stem Cells Australia. Despite progress in stem cell research, scientists do not understand how stem cells “decide” what to become. Stem Cells Australia will draw upon strengths within Australia’s premier stem cell research universities and institutes. This collaboration between leading bioengineering, nanotechnology, stem cell and advanced molecular analysis experts, will fast-track efforts to deliver a fundamental understanding of the mechanisms of stem cell regulation and differentiation, and ....Stem Cells Australia. Despite progress in stem cell research, scientists do not understand how stem cells “decide” what to become. Stem Cells Australia will draw upon strengths within Australia’s premier stem cell research universities and institutes. This collaboration between leading bioengineering, nanotechnology, stem cell and advanced molecular analysis experts, will fast-track efforts to deliver a fundamental understanding of the mechanisms of stem cell regulation and differentiation, and the ability to control and influence this process. Stem Cells Australia will deliver new methods for stem cell propagation and manipulation, new translational technologies for therapeutic applications, and will prepare Australia’s future stem cell scientific leaders.Read moreRead less