We have discovered a single tumour factor which causes cancer cachexia, a wasting condition that is one of the worst complications of malignancy, for which there is no current effective treatment. We have developed antibodies which effectively block this condition in preclinical models and have produced human/humanised version of this. This application is to characterise these human antibodies to allow us proceed to clinical trials.
Affective sensing technology for the detection and monitoring of depression and melancholia. This project will develop reliable and affective sensing technology and evaluate it as an objective measure of depressive disorders; a leading cause of disability worldwide. Outcomes will significantly support and aid clinicians in their diagnosis and treatment, thus providing a major breakthrough with significant research, healthcare and commercial possibilities.
A NOVEL MOUSE MODEL TO INVESTIGATE THE MECHANISMS OF VIRUS-INDUCED ARTHRITIS
Funder
National Health and Medical Research Council
Funding Amount
$336,000.00
Summary
We have developed a novel animal model by which to study arthritic disease caused by insect-transmitted viruses known as arboviruses. The existence of this model and novel reagents provides an excellent opportunity to further explore the basic mechanisms of infectious disease in a complete functioning animal, rather than specific cultured cells. The study will use modern approaches in molecular and cellular biology to achieve this goal. The production by our immune systems of soluble mediators ( ....We have developed a novel animal model by which to study arthritic disease caused by insect-transmitted viruses known as arboviruses. The existence of this model and novel reagents provides an excellent opportunity to further explore the basic mechanisms of infectious disease in a complete functioning animal, rather than specific cultured cells. The study will use modern approaches in molecular and cellular biology to achieve this goal. The production by our immune systems of soluble mediators (cytokines-chemokines) and antibodies is an overwhelming positive aspect of our physiological response to infection by microbes. Protection from disease by these immune compounds can happen naturally, or the body's ability to produce these factors can be exploited to our benefit via the administration of vaccines. However, these factors can also be detrimental to the host contributing to severe disease. For instance, work performed almost 40 years ago showed for the first time that under particular conditions, antibodies against viruses can enhance infection, instead of inhibiting infection as normally seen. In the intervening years work by scientists all over the world has associated antibody-dependent enhancement (ADE) of infection to many types of viruses; ADE is even thought to be a risk factor to serious disease with dengue virus, and has been shown in vitro for the AIDS virus and Ebola virus. We have recently discovered a molecular mechanism which explains how antibody enhances viral infection in vitro. In studies on immune cells infected with Ross River Virus (RRV) we found that infection helped by antibody resulted in the specific disruption to the production of cellular chemicals which are toxic to viruses. Are these mechanisms of antibody-enhanced infection also found in animals? Will such mode of infection cause enhanced disease and tissue pathology (arthritis) in animals?Read moreRead less
Visual Analytics for Next Generation Sequencing. Next-generation sequencing technologies have brought a revolution in biology and healthcare, while taxing the ability of scientists and clinicians to identify and process relevant data, to make sense of it all and communicate it to others in a concise and meaningful way. This project aims to tackle this problem through fundamentally new approaches to data selection and visualisation at very large scale, actively encoding for insight into underlyin ....Visual Analytics for Next Generation Sequencing. Next-generation sequencing technologies have brought a revolution in biology and healthcare, while taxing the ability of scientists and clinicians to identify and process relevant data, to make sense of it all and communicate it to others in a concise and meaningful way. This project aims to tackle this problem through fundamentally new approaches to data selection and visualisation at very large scale, actively encoding for insight into underlying biological and biomedical processes, bringing sustainable discovery of new relationships and variations within the data. The project aims to support new approaches to medical diagnosis and treatment, and offer crucial lessons to address the broader challenge of understanding large, complex data sets.Read moreRead less
Computational Intelligence for Complex Structured Data. This project aims to use computational intelligence techniques to reliably learn adaptive natural human pointing and gestures to control an interface on a pseudo-3D display. Highly complex data with interconnections between elements is hard to visualise on screens. Most current tools are operated using point/click/drag on 2D screens. The physical technology to capture appropriate human behaviours exists already, but not the adaptive learnin ....Computational Intelligence for Complex Structured Data. This project aims to use computational intelligence techniques to reliably learn adaptive natural human pointing and gestures to control an interface on a pseudo-3D display. Highly complex data with interconnections between elements is hard to visualise on screens. Most current tools are operated using point/click/drag on 2D screens. The physical technology to capture appropriate human behaviours exists already, but not the adaptive learning of the syntax and semantics of individual gestures and actions, nor the multi-gesture information fusion required for understanding, which could significantly enhance efficiency, for example, in sorting through named entities in an investigation. All of this is done naturally by most human beings, using biological neural networks.Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC230100001
Funder
Australian Research Council
Funding Amount
$5,000,000.00
Summary
ARC Training Centre for Automated Vehicles in Rural and Remote Regions. The Centre will build skills and capability to test and deploy safe, socially acceptable, automated vehicles (AV) for rural, regional and remote Australian public roads, where manufacturing, agriculture, mining and defence industries face significant challenges of driver shortages, rising costs, long distances, rough roads, and environmental impacts. The centre will unite technology providers, regulators, government and end ....ARC Training Centre for Automated Vehicles in Rural and Remote Regions. The Centre will build skills and capability to test and deploy safe, socially acceptable, automated vehicles (AV) for rural, regional and remote Australian public roads, where manufacturing, agriculture, mining and defence industries face significant challenges of driver shortages, rising costs, long distances, rough roads, and environmental impacts. The centre will unite technology providers, regulators, government and end users with world-leading interdisciplinary researchers to create new human-AV systems, datasets, frameworks, case studies, platforms, and a vastly upskilled workforce. This will reduce transport costs, increase capacity, boost supply chain efficiency and resilience, improve road safety, and elevate Australian capability.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0347131
Funder
Australian Research Council
Funding Amount
$115,490.00
Summary
Intelligent Computer System to Access Information Directly from the Brain Using High Resolution Electroencephalography and Repetitive Transcranial Magnetic Stimulation. The ambitious aim of this project is to create a novel intelligent computer system which accesss information from the brain. To do this we use repetitive Transcranial Magnetic Stimulation and high resolution Electroencephalography.
Industrial Transformation Training Centres - Grant ID: IC170100016
Funder
Australian Research Council
Funding Amount
$3,123,492.00
Summary
ARC Training Centre for Personalised Therapeutics Technologies. The ARC Training Centre for Personalised Therapeutics Technologies aims to create and develop the skills and technology to benefit from the transformative impacts that cell/organ-on-a-chip technology will have on the medtech/pharma industries. By combining microfluidics-based/real-time technologies with personalised medicine the Training Centre will provide industry growth opportunities through improved screening of potential therap ....ARC Training Centre for Personalised Therapeutics Technologies. The ARC Training Centre for Personalised Therapeutics Technologies aims to create and develop the skills and technology to benefit from the transformative impacts that cell/organ-on-a-chip technology will have on the medtech/pharma industries. By combining microfluidics-based/real-time technologies with personalised medicine the Training Centre will provide industry growth opportunities through improved screening of potential therapeutics. The use of an individual patient’s cellular and molecular research findings will ultimately enable personalised diagnostic and therapeutic decisions.Read moreRead less
Industrial Transformation Research Hubs - Grant ID: IH120100021
Funder
Australian Research Council
Funding Amount
$2,500,000.00
Summary
Pathways to market: transforming food industry futures through improved sensing, provenance and choice. Pathways to market: transforming food industry futures through improved sensing, provenance and choice. This Research Hub aims to transform the Australian food industry by demonstrating how new knowledge on food production and consumption generated through novel sensing technologies and advanced modelling techniques can be implemented in smart applications to power competitiveness, sustainabil ....Pathways to market: transforming food industry futures through improved sensing, provenance and choice. Pathways to market: transforming food industry futures through improved sensing, provenance and choice. This Research Hub aims to transform the Australian food industry by demonstrating how new knowledge on food production and consumption generated through novel sensing technologies and advanced modelling techniques can be implemented in smart applications to power competitiveness, sustainability and innovation in food value chains.Read moreRead less
ARC Centre of Excellence for the Digital Child. Our vision is for Australian children to be healthy, educated and connected. This Centre will integrate child health, education, and digital and social connectedness, innovating across disciplines to meet Australia’s ongoing challenges of supporting young children growing up in a rapidly changing digital age. The Centre’s world-leading team investigates children’s digital practices through three interconnected research programs supported by a longi ....ARC Centre of Excellence for the Digital Child. Our vision is for Australian children to be healthy, educated and connected. This Centre will integrate child health, education, and digital and social connectedness, innovating across disciplines to meet Australia’s ongoing challenges of supporting young children growing up in a rapidly changing digital age. The Centre’s world-leading team investigates children’s digital practices through three interconnected research programs supported by a longitudinal family cohort study and children’s technology laboratories. The Centre will address tensions in a contested field to inform government and non-government policy, technology innovation, and develop programs and guidelines for children, families, educators and technology developers. Read moreRead less