We have discovered a single tumour factor which causes cancer cachexia, a wasting condition that is one of the worst complications of malignancy, for which there is no current effective treatment. We have developed antibodies which effectively block this condition in preclinical models and have produced human/humanised version of this. This application is to characterise these human antibodies to allow us proceed to clinical trials.
Special Research Initiatives - Grant ID: SR1101002
Funder
Australian Research Council
Funding Amount
$21,000,000.00
Summary
Stem Cells Australia. Despite progress in stem cell research, scientists do not understand how stem cells “decide” what to become. Stem Cells Australia will draw upon strengths within Australia’s premier stem cell research universities and institutes. This collaboration between leading bioengineering, nanotechnology, stem cell and advanced molecular analysis experts, will fast-track efforts to deliver a fundamental understanding of the mechanisms of stem cell regulation and differentiation, and ....Stem Cells Australia. Despite progress in stem cell research, scientists do not understand how stem cells “decide” what to become. Stem Cells Australia will draw upon strengths within Australia’s premier stem cell research universities and institutes. This collaboration between leading bioengineering, nanotechnology, stem cell and advanced molecular analysis experts, will fast-track efforts to deliver a fundamental understanding of the mechanisms of stem cell regulation and differentiation, and the ability to control and influence this process. Stem Cells Australia will deliver new methods for stem cell propagation and manipulation, new translational technologies for therapeutic applications, and will prepare Australia’s future stem cell scientific leaders.Read moreRead less
A NOVEL MOUSE MODEL TO INVESTIGATE THE MECHANISMS OF VIRUS-INDUCED ARTHRITIS
Funder
National Health and Medical Research Council
Funding Amount
$336,000.00
Summary
We have developed a novel animal model by which to study arthritic disease caused by insect-transmitted viruses known as arboviruses. The existence of this model and novel reagents provides an excellent opportunity to further explore the basic mechanisms of infectious disease in a complete functioning animal, rather than specific cultured cells. The study will use modern approaches in molecular and cellular biology to achieve this goal. The production by our immune systems of soluble mediators ( ....We have developed a novel animal model by which to study arthritic disease caused by insect-transmitted viruses known as arboviruses. The existence of this model and novel reagents provides an excellent opportunity to further explore the basic mechanisms of infectious disease in a complete functioning animal, rather than specific cultured cells. The study will use modern approaches in molecular and cellular biology to achieve this goal. The production by our immune systems of soluble mediators (cytokines-chemokines) and antibodies is an overwhelming positive aspect of our physiological response to infection by microbes. Protection from disease by these immune compounds can happen naturally, or the body's ability to produce these factors can be exploited to our benefit via the administration of vaccines. However, these factors can also be detrimental to the host contributing to severe disease. For instance, work performed almost 40 years ago showed for the first time that under particular conditions, antibodies against viruses can enhance infection, instead of inhibiting infection as normally seen. In the intervening years work by scientists all over the world has associated antibody-dependent enhancement (ADE) of infection to many types of viruses; ADE is even thought to be a risk factor to serious disease with dengue virus, and has been shown in vitro for the AIDS virus and Ebola virus. We have recently discovered a molecular mechanism which explains how antibody enhances viral infection in vitro. In studies on immune cells infected with Ross River Virus (RRV) we found that infection helped by antibody resulted in the specific disruption to the production of cellular chemicals which are toxic to viruses. Are these mechanisms of antibody-enhanced infection also found in animals? Will such mode of infection cause enhanced disease and tissue pathology (arthritis) in animals?Read moreRead less
Power systems with diverse generation - implications, control and capability. This research will generate a systematic methodology to handle the impact of the renewable energy sources on the NSW power grid. It increases our understanding of the impact of climate change policies relating to mandatory targets for greenhouse gas reduction helping to build Australia’s research capacity in the national priority area of an environmentally sustainable Australia. The anticipated methodology can also be ....Power systems with diverse generation - implications, control and capability. This research will generate a systematic methodology to handle the impact of the renewable energy sources on the NSW power grid. It increases our understanding of the impact of climate change policies relating to mandatory targets for greenhouse gas reduction helping to build Australia’s research capacity in the national priority area of an environmentally sustainable Australia. The anticipated methodology can also be seen as protecting the security of power infrastructure as well. Maintaining a critical energy infrastructure protects our way of life and ensures ongoing social, economic and environmental well being of Australia.Read moreRead less
Special Research Initiatives - Grant ID: SR0354551
Funder
Australian Research Council
Funding Amount
$20,000.00
Summary
ARC Research Network for Renewable Energy. The proposed Research Network will integrate and coordinate the entire research field of renewable energy in Australia. This Network covers a diverse range of technologies, and includes all prominent researchers in the area of renewable energy in Australia. The Network is strengthened by the inclusion of key people from government agencies, industry, industry associations and international research organisations.
Australia is a leading player in the ....ARC Research Network for Renewable Energy. The proposed Research Network will integrate and coordinate the entire research field of renewable energy in Australia. This Network covers a diverse range of technologies, and includes all prominent researchers in the area of renewable energy in Australia. The Network is strengthened by the inclusion of key people from government agencies, industry, industry associations and international research organisations.
Australia is a leading player in the world's renewable energy industry. An effective structure for networking and for the exchange of people, information and research results will maintain and improve Australia's position in this rapidly growing industry.Read moreRead less
Pedal and motor cycle helmet performance study. Cycling is a form of recreation and transport. Both pedal and motor cyclists are exposed to risks of head and neck injury. These injuries occur in young people and can have substantial health and economic impacts on the individuals and society. It is believed that injury rates can be reduced and an active lifestyle encouraged by improving helmet performance and understanding factors that lead to non-use. As helmet use is mandatory it is importa ....Pedal and motor cycle helmet performance study. Cycling is a form of recreation and transport. Both pedal and motor cyclists are exposed to risks of head and neck injury. These injuries occur in young people and can have substantial health and economic impacts on the individuals and society. It is believed that injury rates can be reduced and an active lifestyle encouraged by improving helmet performance and understanding factors that lead to non-use. As helmet use is mandatory it is important that Australians are provided with optimal helmets. The specification of product standards is also relevant for international trade agreements. Read moreRead less
The Identification and Development of Strategies for Increasing Engineering Enrolments. There is a continuing nation-wide decline in high school student enrolment in higher level mathematics and science. This is already leading to a reduction in the number of students undertaking university engineering programs in Australia and the situation is expected to worsen. This project is directed toward a better understanding of the reasons for the trend and the development of strategies to reverse it. ....The Identification and Development of Strategies for Increasing Engineering Enrolments. There is a continuing nation-wide decline in high school student enrolment in higher level mathematics and science. This is already leading to a reduction in the number of students undertaking university engineering programs in Australia and the situation is expected to worsen. This project is directed toward a better understanding of the reasons for the trend and the development of strategies to reverse it. It aims to 1. Evaluate the most effective strategies that increase student's interests and understanding of engineering and increase participation in engineering studies. 2. Develop an optimised national communication strategy for promoting engineering studies to secondary students.Read moreRead less
Erosion of embankment dams and dam spillways. In excess of $250M is spent annually to maintain, upgrade, improve safety and monitor performance of Australian dams. Improved methods for assessing both spillway and internal erosion, the cause of 50 per cent of embankment dam failures and incidents requiring repairs, will be developed, maximising dam safety and minimising maintenance expenditure.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0560683
Funder
Australian Research Council
Funding Amount
$321,953.00
Summary
A furnace stack for advanced photovoltaic, photonic and microfabrication applications. Advanced silicon photovoltaic, photonic, optoelectronic and micro-electromechanical devices require state of the art processing equipment for the deposition of thin dielectric films and for controlled doping of the devices. Key techniques include the deposition of stoichiometric and silicon rich silicon nitride and silicon dioxide films, and the controlled wafer doping with boron and phosphorus. A state of the ....A furnace stack for advanced photovoltaic, photonic and microfabrication applications. Advanced silicon photovoltaic, photonic, optoelectronic and micro-electromechanical devices require state of the art processing equipment for the deposition of thin dielectric films and for controlled doping of the devices. Key techniques include the deposition of stoichiometric and silicon rich silicon nitride and silicon dioxide films, and the controlled wafer doping with boron and phosphorus. A state of the art furnace stack is to be procured which will satisfy these requirements on industrially relevant wafer sizes up to 150mm. The equipment will support a broad range of research projects in the above fields, ranging from fundamental investigations to applied research carried out in collaboration with industry partners.Read moreRead less
Novel gas-liquid columns for liquefied natural gas (LNG) production. Novel gas-liquid columns for liquefied natural gas (LNG) production. This project aims to design distillation and absorption columns, perhaps the most important unit operations in a liquefied natural gas (LNG) plant, and whose optimization is integral to overall performance of any LNG plant. This project will use 3D printers to rapidly prototype concepts of columns and their internals, and test them using flow characterization ....Novel gas-liquid columns for liquefied natural gas (LNG) production. Novel gas-liquid columns for liquefied natural gas (LNG) production. This project aims to design distillation and absorption columns, perhaps the most important unit operations in a liquefied natural gas (LNG) plant, and whose optimization is integral to overall performance of any LNG plant. This project will use 3D printers to rapidly prototype concepts of columns and their internals, and test them using flow characterization tools and numerical models. The final outcome of the project will be a set of designs of the columns, which should be more efficient, safer and cheaper to operate, and have smaller physical and environmental footprints, thus helping the Australian LNG industry to stay globally competitive.Read moreRead less