Magnetically controlled drug release from tissue scaffolds for the treatment of acute burns. Severe skin burns are frequently associated with functionally disabling scarring and the risk of death. New magnetically activated wound seals for the treatment of acute burns will be developed that reduce the need for frequent painful dressing changes and hence facilitate rapid healing with a significantly reduced chance of scarring.
Kruppel-like factors and the methylome. This project aims to test the hypothesis that the KLF/SP family of transcription factors work in part via dynamic interactions with methylated cytosine nucleotides in DNA. This is fundamental to their function as pioneer factors in reprograming and their ability to co-ordinate differentiation and organogenesis. Conversely, dynamic changes in methylation status engage or disengage new regulatory elements in the genome via recruitment of KLF/SP family protei ....Kruppel-like factors and the methylome. This project aims to test the hypothesis that the KLF/SP family of transcription factors work in part via dynamic interactions with methylated cytosine nucleotides in DNA. This is fundamental to their function as pioneer factors in reprograming and their ability to co-ordinate differentiation and organogenesis. Conversely, dynamic changes in methylation status engage or disengage new regulatory elements in the genome via recruitment of KLF/SP family proteins as specific effectors. This project will address a new paradigm in genetics that is likely to underpin development.Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC170100016
Funder
Australian Research Council
Funding Amount
$3,123,492.00
Summary
ARC Training Centre for Personalised Therapeutics Technologies. The ARC Training Centre for Personalised Therapeutics Technologies aims to create and develop the skills and technology to benefit from the transformative impacts that cell/organ-on-a-chip technology will have on the medtech/pharma industries. By combining microfluidics-based/real-time technologies with personalised medicine the Training Centre will provide industry growth opportunities through improved screening of potential therap ....ARC Training Centre for Personalised Therapeutics Technologies. The ARC Training Centre for Personalised Therapeutics Technologies aims to create and develop the skills and technology to benefit from the transformative impacts that cell/organ-on-a-chip technology will have on the medtech/pharma industries. By combining microfluidics-based/real-time technologies with personalised medicine the Training Centre will provide industry growth opportunities through improved screening of potential therapeutics. The use of an individual patient’s cellular and molecular research findings will ultimately enable personalised diagnostic and therapeutic decisions.Read moreRead less
Special Research Initiatives - Grant ID: SR1101002
Funder
Australian Research Council
Funding Amount
$21,000,000.00
Summary
Stem Cells Australia. Despite progress in stem cell research, scientists do not understand how stem cells “decide” what to become. Stem Cells Australia will draw upon strengths within Australia’s premier stem cell research universities and institutes. This collaboration between leading bioengineering, nanotechnology, stem cell and advanced molecular analysis experts, will fast-track efforts to deliver a fundamental understanding of the mechanisms of stem cell regulation and differentiation, and ....Stem Cells Australia. Despite progress in stem cell research, scientists do not understand how stem cells “decide” what to become. Stem Cells Australia will draw upon strengths within Australia’s premier stem cell research universities and institutes. This collaboration between leading bioengineering, nanotechnology, stem cell and advanced molecular analysis experts, will fast-track efforts to deliver a fundamental understanding of the mechanisms of stem cell regulation and differentiation, and the ability to control and influence this process. Stem Cells Australia will deliver new methods for stem cell propagation and manipulation, new translational technologies for therapeutic applications, and will prepare Australia’s future stem cell scientific leaders.Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC190100026
Funder
Australian Research Council
Funding Amount
$4,969,663.00
Summary
ARC Training Centre for Cell and Tissue Engineering Technologies. The ARC Training Centre for Cell and Tissue Engineering Technologies aims to provide training to create a highly skilled workforce for the tissue engineering and regenerative medicine sector and to enhance research performance and innovation in Australia through fundamental and applied research carried out in industry-led PhD projects. The research aims to address major aspects of the manufacturing and commercialisation pathway an ....ARC Training Centre for Cell and Tissue Engineering Technologies. The ARC Training Centre for Cell and Tissue Engineering Technologies aims to provide training to create a highly skilled workforce for the tissue engineering and regenerative medicine sector and to enhance research performance and innovation in Australia through fundamental and applied research carried out in industry-led PhD projects. The research aims to address major aspects of the manufacturing and commercialisation pathway and barriers faced by the sector, namely improving process efficiencies, enabling early-stage scale-up (cell/tissue) and development of the sector's supply chain. The knowledge created and research undertaken would help to accelerate commercialisation in regenerative medicine, tissue engineering and cell therapies.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE120100423
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Tissue engineered muscle actuators as evocative cultural objects and vehicles for discourses about material agency and living machines. This interdisciplinary project will be examining shifting perceptions of what is living through case study of a vital-machine; tissue engineered muscle actuators in custom made bioreactors. It will further discourses about posthumanist perceptions of movement as an indicator for life with agency; suggesting new knowledge and modes of inquiry of material life.
Geotechnical and soil-structure interaction properties of soils in Perth CBD. A new underground railway (City Project) will shortly begin construction in Perth CBD. This construction, and its associated high level of monitoring instrumentation, offers a unique opportunity for an extensive and thorough examination of the mechanical properties of Perths soils. The research results emanating from the proposed combination of field monitoring, laboratory investigation and numerical analysis, will gre ....Geotechnical and soil-structure interaction properties of soils in Perth CBD. A new underground railway (City Project) will shortly begin construction in Perth CBD. This construction, and its associated high level of monitoring instrumentation, offers a unique opportunity for an extensive and thorough examination of the mechanical properties of Perths soils. The research results emanating from the proposed combination of field monitoring, laboratory investigation and numerical analysis, will greatly improve the reliability (and hence cost) of future foundation and basement designs in Perth and elsewhere.Read moreRead less
Numerical prediction of train and vehicle induced ground vibrations and their effects on structures. This project will develop an innovative new method based on coupled finite element and scaled boundary finite-element analysis for predicting the ground vibrations induced by road traffic and underground or surface trains. The method will have immediate application in transportation engineering to predict traffic-induced ground vibrations, in geotechnical engineering to design isolation trenches ....Numerical prediction of train and vehicle induced ground vibrations and their effects on structures. This project will develop an innovative new method based on coupled finite element and scaled boundary finite-element analysis for predicting the ground vibrations induced by road traffic and underground or surface trains. The method will have immediate application in transportation engineering to predict traffic-induced ground vibrations, in geotechnical engineering to design isolation trenches and wave barriers to dissipate wave propagation, and in structural engineering to estimate in-structure vibration level and design isolators for sensitive equipment housed within. The technique will involve fundamental advances in the scaled boundary finite-element method, as calculations will be performed in a moving reference frame.Read moreRead less
Future Proofing Transportation Infrastructure Assets. This project seeks to develop a model to predict construction project overruns. Transportation infrastructure assets are prone to cost and schedule overruns during their construction, which have negative impacts on asset owners and users. This project aims to develop a systemic model that can be used to determine the causal nature of cost and schedule overruns and their probability of occurrence. By enabling the predication of overruns, the p ....Future Proofing Transportation Infrastructure Assets. This project seeks to develop a model to predict construction project overruns. Transportation infrastructure assets are prone to cost and schedule overruns during their construction, which have negative impacts on asset owners and users. This project aims to develop a systemic model that can be used to determine the causal nature of cost and schedule overruns and their probability of occurrence. By enabling the predication of overruns, the project aims to ensure that the public and private sector are able to put in place mitigation strategies to reduce the impact of the economic and productivity issues that arise due to overruns.Read moreRead less
Numerical Modelling of Three-dimensional Scour below Offshore Pipelines. Australia's increasing offshore oil and gas exploration has demanded more accurate and reliable methods for evaluating the safety and serviceability of pipelines. Local scour around pipelines is one of the major causes of pipeline failures, and is a major concern in Australian waters. This project not only addresses these concerns in its direct application to the design and management of offshore pipelines, but also will co ....Numerical Modelling of Three-dimensional Scour below Offshore Pipelines. Australia's increasing offshore oil and gas exploration has demanded more accurate and reliable methods for evaluating the safety and serviceability of pipelines. Local scour around pipelines is one of the major causes of pipeline failures, and is a major concern in Australian waters. This project not only addresses these concerns in its direct application to the design and management of offshore pipelines, but also will contribute to the nation's development and competitiveness in offshore exploration, and produce high quality research students. The improved design and management of pipelines in Australian waters will reduce the risk of potential environmental damages caused by leaking gas and oil.Read moreRead less