Kruppel-like factors and the methylome. This project aims to test the hypothesis that the KLF/SP family of transcription factors work in part via dynamic interactions with methylated cytosine nucleotides in DNA. This is fundamental to their function as pioneer factors in reprograming and their ability to co-ordinate differentiation and organogenesis. Conversely, dynamic changes in methylation status engage or disengage new regulatory elements in the genome via recruitment of KLF/SP family protei ....Kruppel-like factors and the methylome. This project aims to test the hypothesis that the KLF/SP family of transcription factors work in part via dynamic interactions with methylated cytosine nucleotides in DNA. This is fundamental to their function as pioneer factors in reprograming and their ability to co-ordinate differentiation and organogenesis. Conversely, dynamic changes in methylation status engage or disengage new regulatory elements in the genome via recruitment of KLF/SP family proteins as specific effectors. This project will address a new paradigm in genetics that is likely to underpin development.Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC170100016
Funder
Australian Research Council
Funding Amount
$3,123,492.00
Summary
ARC Training Centre for Personalised Therapeutics Technologies. The ARC Training Centre for Personalised Therapeutics Technologies aims to create and develop the skills and technology to benefit from the transformative impacts that cell/organ-on-a-chip technology will have on the medtech/pharma industries. By combining microfluidics-based/real-time technologies with personalised medicine the Training Centre will provide industry growth opportunities through improved screening of potential therap ....ARC Training Centre for Personalised Therapeutics Technologies. The ARC Training Centre for Personalised Therapeutics Technologies aims to create and develop the skills and technology to benefit from the transformative impacts that cell/organ-on-a-chip technology will have on the medtech/pharma industries. By combining microfluidics-based/real-time technologies with personalised medicine the Training Centre will provide industry growth opportunities through improved screening of potential therapeutics. The use of an individual patient’s cellular and molecular research findings will ultimately enable personalised diagnostic and therapeutic decisions.Read moreRead less
Special Research Initiatives - Grant ID: SR1101002
Funder
Australian Research Council
Funding Amount
$21,000,000.00
Summary
Stem Cells Australia. Despite progress in stem cell research, scientists do not understand how stem cells “decide” what to become. Stem Cells Australia will draw upon strengths within Australia’s premier stem cell research universities and institutes. This collaboration between leading bioengineering, nanotechnology, stem cell and advanced molecular analysis experts, will fast-track efforts to deliver a fundamental understanding of the mechanisms of stem cell regulation and differentiation, and ....Stem Cells Australia. Despite progress in stem cell research, scientists do not understand how stem cells “decide” what to become. Stem Cells Australia will draw upon strengths within Australia’s premier stem cell research universities and institutes. This collaboration between leading bioengineering, nanotechnology, stem cell and advanced molecular analysis experts, will fast-track efforts to deliver a fundamental understanding of the mechanisms of stem cell regulation and differentiation, and the ability to control and influence this process. Stem Cells Australia will deliver new methods for stem cell propagation and manipulation, new translational technologies for therapeutic applications, and will prepare Australia’s future stem cell scientific leaders.Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC190100026
Funder
Australian Research Council
Funding Amount
$4,969,663.00
Summary
ARC Training Centre for Cell and Tissue Engineering Technologies. The ARC Training Centre for Cell and Tissue Engineering Technologies aims to provide training to create a highly skilled workforce for the tissue engineering and regenerative medicine sector and to enhance research performance and innovation in Australia through fundamental and applied research carried out in industry-led PhD projects. The research aims to address major aspects of the manufacturing and commercialisation pathway an ....ARC Training Centre for Cell and Tissue Engineering Technologies. The ARC Training Centre for Cell and Tissue Engineering Technologies aims to provide training to create a highly skilled workforce for the tissue engineering and regenerative medicine sector and to enhance research performance and innovation in Australia through fundamental and applied research carried out in industry-led PhD projects. The research aims to address major aspects of the manufacturing and commercialisation pathway and barriers faced by the sector, namely improving process efficiencies, enabling early-stage scale-up (cell/tissue) and development of the sector's supply chain. The knowledge created and research undertaken would help to accelerate commercialisation in regenerative medicine, tissue engineering and cell therapies.Read moreRead less
Barriers for cost - effective rock fall hazard mitigation. Rock fall barriers are used throughout Australia to protect its extensive road and rail networks. These networks are vital links in the nation's infrastructure and underpin its economic prosperity and development. There are thousands of cuttings on Australia' transport networks, many of which have the potential to be affected by rock falls. These events can take lives and severely disrupt the performance of our transport infrastructure. ....Barriers for cost - effective rock fall hazard mitigation. Rock fall barriers are used throughout Australia to protect its extensive road and rail networks. These networks are vital links in the nation's infrastructure and underpin its economic prosperity and development. There are thousands of cuttings on Australia' transport networks, many of which have the potential to be affected by rock falls. These events can take lives and severely disrupt the performance of our transport infrastructure. This project will develop new cost-effective methods for designing against rock fall events using a combination of advanced testing and computer modelling.Read moreRead less
Predicting scour and scour-induced settlement of subsea infrastructure. This project aims to develop improved predictions and understanding of the potential and extent of scour and scour-induced settlement of subsea infrastructure on mobile seabeds. This is expected to enable scour and settlement to be accounted for directly in engineering stability and serviceability design, overturning current practice which ignores both effects on the basis of using scour protection and costly maintenance and ....Predicting scour and scour-induced settlement of subsea infrastructure. This project aims to develop improved predictions and understanding of the potential and extent of scour and scour-induced settlement of subsea infrastructure on mobile seabeds. This is expected to enable scour and settlement to be accounted for directly in engineering stability and serviceability design, overturning current practice which ignores both effects on the basis of using scour protection and costly maintenance and remediation. Development of accurate predictions is expected to be achieved through physical model testing, numerical modelling and analysis of field data. Predictions should improve subsea reliability and lead to omission of scour protection in some situations, increasing international competitiveness of our offshore oil and gas industry.Read moreRead less
Securing Australian floating wind developments with helical anchors. This project will reduce the cost of offshore floating wind energy by uniting leading academic expertise and innovative industry partners to develop the knowledge and practical tools that will enable the deployment of helical anchors as a cheap and reliable anchoring system for floating wind. Helical anchors are seen as the most promising solution to anchor wind turbines, but their deployment has been limited by uncertainties a ....Securing Australian floating wind developments with helical anchors. This project will reduce the cost of offshore floating wind energy by uniting leading academic expertise and innovative industry partners to develop the knowledge and practical tools that will enable the deployment of helical anchors as a cheap and reliable anchoring system for floating wind. Helical anchors are seen as the most promising solution to anchor wind turbines, but their deployment has been limited by uncertainties associated with the torque and vertical force required for installation in complex seabeds, and their performance under environmental loading. The project will address these specific points through a combination of physical, numerical and analytical modelling, using data and design scenarios provided by industry.
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Industrial Transformation Training Centres - Grant ID: IC230100015
Funder
Australian Research Council
Funding Amount
$5,000,000.00
Summary
ARC Training Centre for Whole Life Design of Carbon Neutral Infrastructure. This Centre aims to transform the capability of civil infrastructure stakeholders to design, construct, operate and dispose of infrastructure in a carbon neutral way. By training industry-embedded PhDs and postdocs in the methodology and technology required to design out excess carbon of infrastructure in its whole life, this Centre expects to lead the world in sustainable infrastructure design, enabling a new generation ....ARC Training Centre for Whole Life Design of Carbon Neutral Infrastructure. This Centre aims to transform the capability of civil infrastructure stakeholders to design, construct, operate and dispose of infrastructure in a carbon neutral way. By training industry-embedded PhDs and postdocs in the methodology and technology required to design out excess carbon of infrastructure in its whole life, this Centre expects to lead the world in sustainable infrastructure design, enabling a new generation of infrastructure design in Australia and internationally. Achieving carbon neutral infrastructure in its whole life will bring significant far-reaching benefits, including equipping industry with tools required to meet Australia’s emission reduction targets as well as economic, commercial, environmental, and social gains.Read moreRead less