Switching the light on cartilage repair. Osteoarthritis is a leading cause of pain and disability in adults and affects 15 per cent of the Australian population. This project will develop a revolutionary new approach to treat joint disorders using smart materials and stem cells. The novel materials and techniques developed will help Australia maintain its leading edge in biotechnology.
Smart Matrix™ approaches towards neo vascularisation in bone repair. Bone injuries cost Australia more than $1 billion annually. The development of a medical device combining novel pro-angiogenic technology, Smart Matrix™, with polymer scaffolds for treatment of bone defects by this project, will facilitate rapid development of a blood supply within the defect, aiding bone growth and reducing overall costs compared to current treatments.
Development of new systems for the commercial collection, processing and storage of adipose stem cells. This project is aimed at developing a standardised method to commercially extract and expand stem cells from adipose tissue. This product will then be available commercially as a therapeutic treatment.
Dissecting the physiology of multipotent mesenchymal stromal cells to develop vaccine candidates for respiratory disease. The project aims to gain an understanding of how a type of adult stem cell inhibits immune responses that cause asthma. The project will produce new stem cell products and facilitate the design of a vaccine for asthma and other respiratory diseases, which would greatly reduce the burden of such conditions.
Bone tissue engineering using innovative tubular dual-layered nanofiber meshes. Lifetime risks for long-bone fractures in Caucasians over the age of 50 are 17 per cent for women and 6 per cent for men. A clear therapeutic need exists to address the ever-increasing problems of diminished productivity and reduced quality of life associated with bone disorders as the population ages. To address this challenge, the project’s multidisciplinary, international team will develop technologies to heal tib ....Bone tissue engineering using innovative tubular dual-layered nanofiber meshes. Lifetime risks for long-bone fractures in Caucasians over the age of 50 are 17 per cent for women and 6 per cent for men. A clear therapeutic need exists to address the ever-increasing problems of diminished productivity and reduced quality of life associated with bone disorders as the population ages. To address this challenge, the project’s multidisciplinary, international team will develop technologies to heal tibial defects. Furthermore, it will establish Australia's prominence in the tissue engineering field, training the next generation of young scientists and engineers. This technology will be of interest to numerous research groups and companies worldwide and will foster international collaboration, placing Australia at the forefront of this emerging field.Read moreRead less
The development of new scaffolds for bone repair comprising polycaprolactone and strontium-substituted bioactive glasses. The drive to develop bone grafts to fill major gaps in the skeleton, whilst circumventing the need to use permanent implants has led to a major research thrust towards developing biomaterials for bone-tissue engineering. The project will develop scaffolds with highly osteoconductive bioactive glasses in a polymer matrix for bone regeneration applications.
Enhanced Analysis of Time Dependent Viscous Behaviour of Soft Clay. Often post construction settlements of structures overlying clayey soils have been observed to be more than those predicted, or the predicted rate of settlement is not correct. The main benefit of this research is providing an accurate but simplified approach, which can be used by practicing engineers to predict the post construction settlement of structures in the design phase of construction projects. The community can conside ....Enhanced Analysis of Time Dependent Viscous Behaviour of Soft Clay. Often post construction settlements of structures overlying clayey soils have been observed to be more than those predicted, or the predicted rate of settlement is not correct. The main benefit of this research is providing an accurate but simplified approach, which can be used by practicing engineers to predict the post construction settlement of structures in the design phase of construction projects. The community can considerably benefit from the findings of this project including safer structures, significant reduction in the future maintenance costs and enhancing the performance of bridges, buildings, roads, railways and dams with less cracks and differential settlement.Read moreRead less
Geotechnical and soil-structure interaction properties of soils in Perth CBD. A new underground railway (City Project) will shortly begin construction in Perth CBD. This construction, and its associated high level of monitoring instrumentation, offers a unique opportunity for an extensive and thorough examination of the mechanical properties of Perths soils. The research results emanating from the proposed combination of field monitoring, laboratory investigation and numerical analysis, will gre ....Geotechnical and soil-structure interaction properties of soils in Perth CBD. A new underground railway (City Project) will shortly begin construction in Perth CBD. This construction, and its associated high level of monitoring instrumentation, offers a unique opportunity for an extensive and thorough examination of the mechanical properties of Perths soils. The research results emanating from the proposed combination of field monitoring, laboratory investigation and numerical analysis, will greatly improve the reliability (and hence cost) of future foundation and basement designs in Perth and elsewhere.Read moreRead less
Stabilization of railway subgrade by lime-flyash slurry injection. The rail network in Australia provides a major transport route for commuters as well as transportation of goods. The subgrade of railway track should provide adequate support for the overlying ballast and capping layers. Hence, a poor subgrade always results in track problems associated with uneven track, fouled ballast, and misalignment of the track. This project will investigate in detail the fundamental mechanisms and key para ....Stabilization of railway subgrade by lime-flyash slurry injection. The rail network in Australia provides a major transport route for commuters as well as transportation of goods. The subgrade of railway track should provide adequate support for the overlying ballast and capping layers. Hence, a poor subgrade always results in track problems associated with uneven track, fouled ballast, and misalignment of the track. This project will investigate in detail the fundamental mechanisms and key parameters involved in the improvement of subgrade soil by injecting lime-flyash slurry. This project will develop an improved design procedure for lime-flyash slurry injection in the field based on experimental and numerical modelling.Read moreRead less
Development of sophisticated structural design guidelines for the new building product known as Rapidwall. Rapidwall is an Australian made new composite building product made from formulated gypsum plaster and glass-fibre. This is a high-tech building product that has huge potential to be developed into a dominant building material in the future. It is economic, labor effective, eco-friendly, structural sound and fire, thermal resistant and has many advantages over the existing building material ....Development of sophisticated structural design guidelines for the new building product known as Rapidwall. Rapidwall is an Australian made new composite building product made from formulated gypsum plaster and glass-fibre. This is a high-tech building product that has huge potential to be developed into a dominant building material in the future. It is economic, labor effective, eco-friendly, structural sound and fire, thermal resistant and has many advantages over the existing building materials, such as concrete, steel and masonry. The lack of a technical design guidelines has fundamentally obstructed it from expanding its market share both in Australia and overseas. This proposal aims at developing a structural design manual for the new product.Read moreRead less