A Novel Strategy For The Treatment Of Chronic Skeletal Joint Defects
Funder
National Health and Medical Research Council
Funding Amount
$318,768.00
Summary
Skeletal joint injuries often heal poorly with current treatment approaches and lead to the onset of osteoarthritis. This project will produce a synthetic graft with unique properties to mimic the complex structure of joint tissues, and high bioactivity to induce optimal healing of the joint. This graft will constitute a viable alternative for the treatment of skeletal joint defects, resulting in significant healthcare benefits and improved long-term outcomes.
Multimodal Woven BioPolymer Fibre Conduits For Remodelling Damaged Peripheral Nerve
Funder
National Health and Medical Research Council
Funding Amount
$686,901.00
Summary
Damage to peripheral nerve arises as a result of trauma or disease ranging in severity from mild to severe incapacitation. Currently surgeons remove healthy nerve from individuals with nerve damage to repair more important priority nerves. We aim to create an effective implant for nerve repair that totally degrades leaving behind the regenerated nerve. This will eliminate the need for nerve harvesting as well as restoring lost nerve function in individuals with nerve injury.
Smart Hybrid Material For Cartilage Tissue Engineering
Funder
National Health and Medical Research Council
Funding Amount
$299,564.00
Summary
Tissue engineering is a promising approach to repair damaged/degenerated cartilage caused by various diseases or injuries. Because of its limited capacity for self repair cartilage becomes a constriant to normal everyday life once degenerated. This project aims to develop composite polymers for cartilage repair. The potential of this newly developed material for cartilage tissue engineering will be investigated through the material and biological characterisation techniques.
There is an urgent need for engineered tissue repair and replacement components for cartilage implantation in damaged joints due to a shortage of donor tissue. This project will generate smart composite biomaterials with enhanced mechanical strength and physical properties that are desirable for cartilage repair. The fabricated scaffolds will mimic the microstructure of native cartilage and are next-generation biomaterials designed to facilitate cartilage regeneration.
Bioactivated Hierarchical Hydrogels As Zonal Implants For Articular Cartilage Regeneration
Funder
National Health and Medical Research Council
Funding Amount
$353,161.00
Summary
Cartilage is frequently damaged, but does not repair on its own, and degenerates in osteoarthritis. Unfortunately, current treatments are also not able to regenerate the structure of normal cartilage and fail to restore joint function long-term. Our project, HydroZONES, brings together expertise from 16 partners to tackle this problem and regenerate cartilage with the appropriate structure to help the millions of people worldwide suffering from cartilage problems such as osteoarthritis.
Biothermosetting Bone Filler: An Injectable Osteoconductive Repair Material
Funder
National Health and Medical Research Council
Funding Amount
$601,698.00
Summary
Bone injury is a common and profoundly debilitating issue, and is responsible for extended partial or complete loss of mobility and associated economic impact during slow healing. There is strong demand for technology that reduces the time taken for bone repair. There is still a paucity of clinically effective biocompatible materials for treatment. We have developed a novel approach for a thermoresponsive hydrogel with unique properties suitable for rapid bone filling and regeneration.
Functional Nano-cement Scaffolds For The Treatment Of Osteoporotic Bone Defects
Funder
National Health and Medical Research Council
Funding Amount
$408,768.00
Summary
Osteoporosis affects 1.2 million Australians and will cost $33.6 billion by 2022. This study aims to develop a novel nano-cement platform for custom-designed bone repair in osteoporosis, by using purpose-designed nanomaterials and advanced 3D printing technique. The research findings will lead to the development of a new bone repair strategy, expand knowledge on both biomaterials engineering and osteoporosis treatment, and improve the quality of life of Australians.
Development Of Gene-activated Scaffolds As Bone Bioreactor For Bone Regeneration And Osteointegration
Funder
National Health and Medical Research Council
Funding Amount
$215,100.00
Summary
The worldwide market for bone substitutes has been estimated at over US $1 billion annually. The emerging technology of cell based therapy has opened a new window for the treatment of bone defects. This project is to develop gene-activated scaffolds able to induce blood vessel formation thus improving the local nutrition supply, and subsequently stimulating bone formation in bone defects, as well as osteointegration around implant surface. The knowledge generated from this project will help the ....The worldwide market for bone substitutes has been estimated at over US $1 billion annually. The emerging technology of cell based therapy has opened a new window for the treatment of bone defects. This project is to develop gene-activated scaffolds able to induce blood vessel formation thus improving the local nutrition supply, and subsequently stimulating bone formation in bone defects, as well as osteointegration around implant surface. The knowledge generated from this project will help the treatment of a number of orthopaedic and dental conditions.Read moreRead less
Pre-clinical Validation Of A Novel Implant For Bone Tissue Engineering
Funder
National Health and Medical Research Council
Funding Amount
$435,767.00
Summary
The aim of this grant to was examine a new method for manufacturing implants to improve repair of critical bone defects. It involves new technology for the manufacture of porous scaffolds and testing their delivery in a biological, bone repair setting.