Dissecting The Roles Of Steroid Hormone Receptors In The Mammary Gland
Funder
National Health and Medical Research Council
Funding Amount
$92,314.00
Summary
Breast cancer remains a major cause of death in women, requiring the development of highly efficient therapeutics. Research into the molecular and cellular mechanisms of the normal mammary gland is crucial. This project will increase our understanding of the normal roles of the estrogen and progesterone receptors. This research may have significant implications for clinical studies that use more targeted therapies.
Inherited Muscle Disorders - Gene Discovery, Pathobiology And Therapy.
Funder
National Health and Medical Research Council
Funding Amount
$1,750,277.00
Summary
The project proposed by Professors Nigel Laing and Kathryn North and Dr Kristen Nowak is based upon the results of their successful identification of disease genes for genetic muscle diseases. The project is divided into three parts. In the first part of the project, the research team will identify further novel disease genes, some of which they are already close to finding. In the second part of the project the team will determine how the mutations they have identified in the disease genes actu ....The project proposed by Professors Nigel Laing and Kathryn North and Dr Kristen Nowak is based upon the results of their successful identification of disease genes for genetic muscle diseases. The project is divided into three parts. In the first part of the project, the research team will identify further novel disease genes, some of which they are already close to finding. In the second part of the project the team will determine how the mutations they have identified in the disease genes actually cause the diseases. The aim of this work is to discover targets that may ultimately lead to new therapies for these muscle diseases. In the third and final part of the project, the team will pursue one possible therapeutic approach, which is based upon the understanding of the diseases the researchers have gained from their previous studies. There are currently no cures for these muscle diseases, though symptoms can be treated. The team will determine whether heart actin can replace muscle actin in skeletal muscle and thus might treat the muscle disease.Read moreRead less
To Repair An Osteo-chondral Defect In An Experimental Rabbit Model Using A Structured 3D Nano-composite Scaffold Loaded With Mesenchymal Stem Cells (MSC)
Funder
National Health and Medical Research Council
Funding Amount
$92,314.00
Summary
The treatment of cartilage damage is a major problem in orthopaedic practice. The use of a 3D scaffold may overcome many challenges associated with cartilage and bone repair and regeneration. The aim of this research is to culture bone and cartilage cells into a prefabricated scaffold which may then be tested in an animal model. The results of this research may offer a new method of treating post-traumatic and osteoarthritic defects.
Systems Analyses Of Prostate Cancer Organoid Cultures For Precision Medicine
Funder
National Health and Medical Research Council
Funding Amount
$430,766.00
Summary
During this fellowship a research platform will be established that can efficiently predict new treatment combinations for prostate cancer. To do this, computational analyses of patient prostate cancer “organoid” cultures subjected to a panel of therapeutic drugs will be performed, to predict effective treatment combinations for any tumour of interest. Accordingly, this work will establish a foundation to decipher successful treatment regimes on an individual patient basis.