Tenecteplase Versus Alteplase For Stroke Thrombolysis Evaluation (TASTE) Trial
Funder
National Health and Medical Research Council
Funding Amount
$4,180,030.00
Summary
Tenecteplase versus Alteplase for Stroke Thrombolysis Evaluation (TASTE) is an Australian-led international randomised trial designed to generate practice-changing evidence by translating the advanced imaging treatment selection approach used in our previous pilot studies. TASTE aims to confirm the superiority of the new-generation clot-dissolving agent, tenecteplase, over the standard agent, alteplase, in the broad group of stroke patients eligible for acute clot-dissolving treatment.
Deciphering The Metabolic And Endocrine Profile Of Healthy Adipocytes
Funder
National Health and Medical Research Council
Funding Amount
$563,194.00
Summary
Obesity is associated with the development of metabolic diseases, however, it is becoming clear that it is where the excess fat is stored that is more important when predicting the health risks associated with obesity. This project aims to identify whether adipocyte progenitor cells, which eventually become fat cells, are ‘preprogrammed’ and whether differences in these cells explain the generation of either healthy or unhealthy fat in different locations of the body.
Comparison Of Periodontal Ligament Stem Cells And Induced Pluripotent Periodontal Ligament Stem Cells For Periodontal Regeneration
Funder
National Health and Medical Research Council
Funding Amount
$831,955.00
Summary
In the first part of this study we will determine whether induced pluripotent stem cells or adult stem cells from the periodontal ligament are better candidates for periodontal regeneration. Secondly, using CAD/CAM technology we will make tissue engineering scaffolds tailored to fit periodontal defects and seeded with stem cells to improve on current techniques used to regenerate damaged tissues around teeth affected by periodontal disease.
Investigating Human Keratinocyte Stem Cells And Their Microenvironmental Niche
Funder
National Health and Medical Research Council
Funding Amount
$570,928.00
Summary
The stem cells in the outer protective layers of the epithelium of the skin (keratinocyte stem cells), possess an intrinsically high capability to regenerate tissue. However, this tissue regenerative ability can be enhanced by interactions with microenvironmental elements i.e. connective tissue cells and proteins. This study seeks to investigate specific keratinocyte-microenvironment interactions which will ultimately be used to improve current methods for generating skin tissue for burns patien ....The stem cells in the outer protective layers of the epithelium of the skin (keratinocyte stem cells), possess an intrinsically high capability to regenerate tissue. However, this tissue regenerative ability can be enhanced by interactions with microenvironmental elements i.e. connective tissue cells and proteins. This study seeks to investigate specific keratinocyte-microenvironment interactions which will ultimately be used to improve current methods for generating skin tissue for burns patients.Read moreRead less
Short Duration Hypothermia To Prevent Subsequent Intracranial Pressure Rise.
Funder
National Health and Medical Research Council
Funding Amount
$436,453.00
Summary
Elevated brain pressure after stroke or other forms of brain injury can cause further injury and death. Body cooling to 32-33 C (hypothermia) for 12-24 hours saves lives after some forms of brain injury, but may have major side effects. We found that 2 hours hypothermia has a long-lasting effect preventing pressure elevation. We will determine the best temperature and duration of hypothermia in a stroke model and use imaging to confirm findings in patients, with a view to later human trials.
Osteochondroreticular Stem Cell Therapy For Osteoarthritis: The Right Cells For The Job.
Funder
National Health and Medical Research Council
Funding Amount
$561,956.00
Summary
"Wear and tear" arthritis of the knee, hip and back joints is known as osteoarthritis. This causes significant health burden and costs in our community, particularly in older Australians. Osteoarthritis begins with the loss of joint cartilage. We believe that a new type of stem cells (OCR stem cells) offer the greatest promise to generate and thus therapeutically replace joint cartilage. Our studies test this hypothesis and develop preclinical translation of our discoveries in mice into humans.
EXTEND-IA Randomized Trial Of Intra-arterial Clot Retrieval In Ischemic Stroke
Funder
National Health and Medical Research Council
Funding Amount
$764,534.00
Summary
Most strokes are caused by a blocked blood vessel in the brain. Current treatments to dissolve the blockage improve recovery for many patients but often fail to unblock larger brain arteries. The EXTEND-IA trial will use advanced brain imaging to identify patients who have the most to gain if the blocked artery can be re-opened. The trial will test whether a new minimally invasive clot removal procedure performed after standard clot-dissolving treatment improves recovery after stroke.
Transcriptome Landscape Of Brown/beige Adipogenesis In Humans
Funder
National Health and Medical Research Council
Funding Amount
$393,369.00
Summary
There are three kinds of fat in the body: white, brown and beige. While excess white fat results in obesity, brown fat is associated with leanness and lowers blood glucose levels. Recent animal experiments show that under certain conditions, white fat can be transformed into beige fat, leading to benefits such as weight loss. The current project grant involves examination of human fat cells grown in the laboratory and investigation on the genetics of brown and beige fat.
Upscaling Cardiac Tissue Engineering: Differentiation Of IPS Cells, Enrichment And Bionic Approaches
Funder
National Health and Medical Research Council
Funding Amount
$709,758.00
Summary
Stem cell therapies to repair heart muscle are experimental methods which promise future clinical treatments. Our tissue engineering chamber model provides a protective environment for implanted cells and generates contracting heart tissue. Towards clinical application we will scale up the tissue volume produced by: improving cell supply with new stem cell technologies, design chambers for bulk cell implantation, adopt a bionic approach to cell pacing and apply the model into larger animals.
Transgenerational Effects Of Male Obesity - Mechanisms And Interventions
Funder
National Health and Medical Research Council
Funding Amount
$829,143.00
Summary
Childhood obesity is associated with obesity in either parent, and obese children tend to become obese adults, forming an intergenerational cycle that promotes obesity. We have identified paternal obesity as an important novel target for intervention to stop the progression of the obesity epidemic. This project investigates supplementation of obese fathers with folate to prevent the adverse impact of paternal obesity on subsequent generations.