Creating a non-invasive window into the mind. This project aims to create better tools to study the human mind. This project expects to generate new knowledge that can be used to non-invasively image neuronal activity. Expected outcomes include the development of unique new Magnetic Resonance Imaging (MRI) instruments to study neuronal activity in both highly controlled laboratory conditions and in humans, with the spatial and temporal resolution needed to study the neuronal circuitry that drive ....Creating a non-invasive window into the mind. This project aims to create better tools to study the human mind. This project expects to generate new knowledge that can be used to non-invasively image neuronal activity. Expected outcomes include the development of unique new Magnetic Resonance Imaging (MRI) instruments to study neuronal activity in both highly controlled laboratory conditions and in humans, with the spatial and temporal resolution needed to study the neuronal circuitry that drives low and high-level brain functions, i.e., creating a window into the mind. In the future, outcomes from this study could improve our understanding of mental disorders, advance computer brain interface technology, and inspire the next paradigm shift in artificial intelligence.Read moreRead less
Touch and Tension: Molecular Determinants of Human Mechanosensation . Feelings of touch and muscle tension are initiated by mechanosensory neurons found within the peripheral nervous system. Knowledge of human mechanosensory neurons has predominantly relied on rodent studies because of the limited availability of human tissue, which is not ideal. Our team has developed novel technologies for generating human mechanosensory neurons ‘in the dish’. The major aim of this project is to use human stem ....Touch and Tension: Molecular Determinants of Human Mechanosensation . Feelings of touch and muscle tension are initiated by mechanosensory neurons found within the peripheral nervous system. Knowledge of human mechanosensory neurons has predominantly relied on rodent studies because of the limited availability of human tissue, which is not ideal. Our team has developed novel technologies for generating human mechanosensory neurons ‘in the dish’. The major aim of this project is to use human stem cell-derived mechanosensory neurons as a platform to extensively study their molecular and functional properties. The significant benefits are the advancement of knowledge in the human mechanosensory system, which to date has been lacking, and in the long-term progress commercial development of novel drugs.Read moreRead less
An anti-senescence nanoplatform and its underlying mechanism. The project will bring together complementary expertise and skills by combining biomaterials, cell and molecular biology, and engineering, to develop a novel nano-biomaterial platform for anti-senescence and gain an in-depth understanding of its underlying mechanisms. The underlying mechanisms of senescence remain elusive and bone substitutes with anti-senescence property have not been explored and becoming a growing field of interest ....An anti-senescence nanoplatform and its underlying mechanism. The project will bring together complementary expertise and skills by combining biomaterials, cell and molecular biology, and engineering, to develop a novel nano-biomaterial platform for anti-senescence and gain an in-depth understanding of its underlying mechanisms. The underlying mechanisms of senescence remain elusive and bone substitutes with anti-senescence property have not been explored and becoming a growing field of interest in bone regeneration. The project will develop a well-defined and efficient nanomaterial platform with optimal combination of nano-surface features and chemistry for cell rejuvenation, and it will give unprecedented depth of interdisciplinary understanding of senescence rejuvenation mechanisms.Read moreRead less
Tuning mesenchymal stem cell lifespan, performance, and differentiation. This project aims to fully characterise a unique molecular process that strongly modulates mesenchymal stem cell lifespan and behaviour. This work is significant, as it is expected to reveal new concepts underpinning the mechanistic actions of classical structural proteins. It will also shape a more nuanced understanding of the context-dependent mechanical and biochemical signals that regulate stem cell fate and function. E ....Tuning mesenchymal stem cell lifespan, performance, and differentiation. This project aims to fully characterise a unique molecular process that strongly modulates mesenchymal stem cell lifespan and behaviour. This work is significant, as it is expected to reveal new concepts underpinning the mechanistic actions of classical structural proteins. It will also shape a more nuanced understanding of the context-dependent mechanical and biochemical signals that regulate stem cell fate and function. Expected outcomes include new knowledge surrounding native extracellular matrix and stem cell biology, and the development of strategies to define and tailor stem cell properties. This work is anticipated to drive new technologies that can efficiently and robustly manipulate stem cells for diverse functional applications.Read moreRead less
Computational fracture analysis of structures and materials. This project aims to develop a computer simulation technique to address the safety of engineering structures. A novel numerical framework based on the scaled boundary finite element method will be developed to model the fracture process critical to assessing structural integrity. The expected outcomes of this project include an innovative technology for numerical simulation and improved capabilities to generate high-fidelity predictio ....Computational fracture analysis of structures and materials. This project aims to develop a computer simulation technique to address the safety of engineering structures. A novel numerical framework based on the scaled boundary finite element method will be developed to model the fracture process critical to assessing structural integrity. The expected outcomes of this project include an innovative technology for numerical simulation and improved capabilities to generate high-fidelity predictions of structural safety at minimum human efforts. The fully automatic and robust numerical tool developed in this project will help engineers and government authorities to perform safe and cost-effective design and management of engineering structures that are vital to modern economies.Read moreRead less
Non-differentiable Energy Minimisation For Modelling Fractured Porous Media. This project is aimed at advancing theoretical, computational and experimental bases for the fracturing of geomaterials, and providing scientists and engineers with much needed predictive tools for quantitative assessment of the responses. By incorporating previously neglected aspects such as energy minimisation, advanced constitutive modelling, and non-planar interacting fracture growth, confidence in the design and pl ....Non-differentiable Energy Minimisation For Modelling Fractured Porous Media. This project is aimed at advancing theoretical, computational and experimental bases for the fracturing of geomaterials, and providing scientists and engineers with much needed predictive tools for quantitative assessment of the responses. By incorporating previously neglected aspects such as energy minimisation, advanced constitutive modelling, and non-planar interacting fracture growth, confidence in the design and planning of engineering processes in fractured porous media will be increased to the point that costly over/under designs are avoided. Through the use of the tools developed, it will be possible to detect weaknesses in the design, assess the impact and implement effective measures to improve performance.Read moreRead less
Modelling creep and time-dependency in unsaturated soils. This project aims to present the most complete and rigorous modelling framework for creep and time-dependent behaviour of unsaturated soils in infrastructure. The project will address previously neglected aspects of soil behaviour, such as gradual changes in physical properties with time and strain-rate dependency. The project is expected to enable better predictions of infrastructure performance, improve confidence in design, and avoid u ....Modelling creep and time-dependency in unsaturated soils. This project aims to present the most complete and rigorous modelling framework for creep and time-dependent behaviour of unsaturated soils in infrastructure. The project will address previously neglected aspects of soil behaviour, such as gradual changes in physical properties with time and strain-rate dependency. The project is expected to enable better predictions of infrastructure performance, improve confidence in design, and avoid unwarranted over-design and the considerable cost this imposes. The project will provide a fully validated predictive computational modelling tool for quantitative assessment of long-term performance and stability of infrastructure such as dams, embankments, tunnels, slopes, buildings and foundations.Read moreRead less
Robustness-oriented and serviceable design of innovative modular buildings. This project aims to unlock the full potential of prefabricated modular buildings through innovative framing solutions in combination with new evaluation methods to enhance serviceability and improve safety under extreme events. Advanced 3D hybrid testing and analysis will be used to create new knowledge on the complex system-level dynamic behaviour of modular buildings. The expected outcome of this project will lead to ....Robustness-oriented and serviceable design of innovative modular buildings. This project aims to unlock the full potential of prefabricated modular buildings through innovative framing solutions in combination with new evaluation methods to enhance serviceability and improve safety under extreme events. Advanced 3D hybrid testing and analysis will be used to create new knowledge on the complex system-level dynamic behaviour of modular buildings. The expected outcome of this project will lead to safe, affordable, and environmentally sustainabe modular building construction. The project will provide significant benefits to designers, manufacturers and regulators to improve the resilience of the building stock and to support greater design and manufacturing innovations.Read moreRead less
Assessing Water Supply Security in a Nonstationary Environment. About 25% of the global population currently has inadequate access to safe and secure water. This number is expected to rise to 50% by 2050 due to increased populations and reduced river flows. While a visible water crisis (such as the one in Cape Town in 2018) can culminate in the funding of new water supply infrastructure, a planned push for infrastructure augmentation often stalls due to contradictory projections of how much wate ....Assessing Water Supply Security in a Nonstationary Environment. About 25% of the global population currently has inadequate access to safe and secure water. This number is expected to rise to 50% by 2050 due to increased populations and reduced river flows. While a visible water crisis (such as the one in Cape Town in 2018) can culminate in the funding of new water supply infrastructure, a planned push for infrastructure augmentation often stalls due to contradictory projections of how much water will be available in the future. To address this, a novel alternative for assessing water security is proposed. Our approach assesses change using historical information on river flow and water demand, adapting these to form projections that exhibit greater reliability than currently existing alternatives.Read moreRead less
Preventing extreme granular wear of geotechnical machinery. This project will investigate the mechanisms controlling the mechanical wear that is incurred while handling geomaterials such as sand, ore, coal and fragmented rock. The overarching aim is to help forecast and mitigate extreme wear conditions by analysing the microscopic forces that granular materials produce when in contact with moving metallic surfaces. The intended outcomes include a thorough understanding of these interfacial inter ....Preventing extreme granular wear of geotechnical machinery. This project will investigate the mechanisms controlling the mechanical wear that is incurred while handling geomaterials such as sand, ore, coal and fragmented rock. The overarching aim is to help forecast and mitigate extreme wear conditions by analysing the microscopic forces that granular materials produce when in contact with moving metallic surfaces. The intended outcomes include a thorough understanding of these interfacial interactions and an experimentally validated theory predicting wear rates for a range of materials and handling processes. The expected benefit of this project is to enhance the productivity and reliability of the mining and construction sectors by reducing wear-related machinery failures.Read moreRead less