Development Of Targeted Therapies To Reverse The Effects Of Ageing And Disease On Wound Healing And Tissue Generation
Funder
National Health and Medical Research Council
Funding Amount
$391,228.00
Summary
Despite success with the production of new tissues and organs in laboratory animals, tissue engineering in humans remains elusive. Emerging evidence suggests that ageing and diseases such as diabetes can adversely affect human stem cell regenerative capacity. Characterizing the effects of ageing and disease on stem cells during tissue generation is the first step in reversing these effects, paving the way for the production of new tissues and organs for use in human clinical trials.
Smart Hybrid Material For Cartilage Tissue Engineering
Funder
National Health and Medical Research Council
Funding Amount
$299,564.00
Summary
Tissue engineering is a promising approach to repair damaged/degenerated cartilage caused by various diseases or injuries. Because of its limited capacity for self repair cartilage becomes a constriant to normal everyday life once degenerated. This project aims to develop composite polymers for cartilage repair. The potential of this newly developed material for cartilage tissue engineering will be investigated through the material and biological characterisation techniques.
Clinical Research Translation In Fluorescence-guided Surgery Of Brain Cancer: Developing A Surgical Endoscope With Enhanced Contrast
Funder
National Health and Medical Research Council
Funding Amount
$318,768.00
Summary
This proposal aims to improve the life expectancy of brain cancer patients by developing a new neurosurgical optical imaging device. The technology will transform the recently developed fluorescence-guided surgery procedure, where the tumour is endowed with artificial fluorescence. Our state-of-the art technology will enhance the fluorescence detection beyond visual perception to help remove hard-to-detect small cancer cell clusters, resulting in more accurate surgical removal of tumours.
Imaging Of Acute Ischemic Stroke – Improving Patient Selection For Thrombolysis
Funder
National Health and Medical Research Council
Funding Amount
$367,946.00
Summary
Stroke is a major cause of death and disability in our community and is most often due to a blocked blood vessel. Powerful treatments are available to open blocked blood vessels but there are restrictions on eligibility and some risks. This research aims to improve doctors' understanding of stroke in the individual patient to aid treatment decisions by identifying those with potentially salvageable brain tissue and avoiding those with high risk of bleeding complications.
Improving Methodolgies For The Early Detection Of Disease
Funder
National Health and Medical Research Council
Funding Amount
$317,860.00
Summary
Early detection of tumours and diseases is vital for an effective and successful treatment. Current early detection methods are invasive and use toxic or radioactive chemicals. This project focuses on understanding how non-toxic, non-invasive ‘smart’ polymeric devices would work for early disease detection. It will provide next generation early detection devices which will reduce the cost of treatment, and increase the effectiveness of therapy.