Discovery And Translation Of Disease Causing Mutations With Genomic And Transcriptomic Data
Funder
National Health and Medical Research Council
Funding Amount
$622,655.00
Summary
This proposal will develop and apply methods for the analysis of genetic data generated from family and cohort studies of collaborators to identify genetic risk loci for both neurogenetic disorders and infectious diseases, particularly malaria. The project will combine large-scale datasets of different types and across different species. This will require the development and application of multivariate statistical analysis methods suited to the data.
Developing And Applying Statistical Genetics Methods To Identify Genes, Molecular Biomarkers And Environmental Agents That Causally Affect Risk Of Complex Musculoskeletal Diseases
Funder
National Health and Medical Research Council
Funding Amount
$707,370.00
Summary
My aim is to identify genes, biological molecules and environmental factors that causally affect risk of osteoporosis and ankylosing spondylitis (a form of autoimmune arthritis) using novel and existing statistical genetics methodologies. My research will advance understanding of the causes of these diseases, identify new opportunities for their treatment, and provide the scientific community with new statistical methods and software to identify factors that causally influence risk of disease.
Applying Next Generation Sequencing To Family Studies
Funder
National Health and Medical Research Council
Funding Amount
$182,622.00
Summary
Recent advances in technology can determine the DNA composition of a person for much longer stretches of DNA, at a much cheaper cost. I use statistical analysis to identify regions of the human genome that harbour mutations that cause diseases such as epilepsy in families. These regions contain 5-15 million base pairs. We need to find the ONE base pair that causes disease. This application deals with the development of new tools to exploit new technology for the identification of mutations.
Innovations In Cancer Imaging And Targeted Radiotherapy To Improve Human Health
Funder
National Health and Medical Research Council
Funding Amount
$926,980.00
Summary
Through a process of discovery, development and investigation we will create medical devices and methods to improve cancer imaging and targeted radiotherapy. Successful completion of this program will directly impact on the treatment and lives of Australian cancer patients in the foreseeable future.This program will substantially build research capacity and productivity within Australia, raise Australia’s profile in cancer research and foster international collaboration.
Through this Australia Fellowship, Prof Keall and his tream will substantially improve the accuracy and effectiveness of radiation therapy for cancer by developing new techniques that will be able to ‘target’ a tumour in real-time and ‘concentrate fire’ on the most resistant and aggressive parts of it. Success in physiological targeting will create a paradigm shift in radiation therapy and could literally be a lifesaver. It’s a big challenge, but if this five-year research program succeeds, it w ....Through this Australia Fellowship, Prof Keall and his tream will substantially improve the accuracy and effectiveness of radiation therapy for cancer by developing new techniques that will be able to ‘target’ a tumour in real-time and ‘concentrate fire’ on the most resistant and aggressive parts of it. Success in physiological targeting will create a paradigm shift in radiation therapy and could literally be a lifesaver. It’s a big challenge, but if this five-year research program succeeds, it will pay big dividendsRead moreRead less
Mental illness is the largest single cause of disability in Australia. While mental illness is increasingly recognised as a disorder of the brain, a patient’s diagnosis, treatment and prediction of course of outcome is seldom guided by the results of a biological test. My research aims to combine the power of modern brain imaging and cutting-edge bioinformatics to enable a biological approach to the problem of mental illness.
Lipid Biology For Prediction And Prevention Of Psychotic Disorders And Persistent Depression In Young People
Funder
National Health and Medical Research Council
Funding Amount
$638,517.00
Summary
My vision for the next 5 years is to establish ?-3PUFAs as a first-line treatment for indicated prevention of psychosis and persistent depression, as an alternative to conventional antidepressants for the treatment of moderate-to-severe depressive symptoms in adolescents and to build capacity in this area by training the next generation of researchers.
Public Health Communication Strategies To Reduce Population Smoking Prevalence
Funder
National Health and Medical Research Council
Funding Amount
$753,300.00
Summary
This research program will investigate the potential for and impact of advanced tobacco control policies in reducing population smoking prevalence. My research will assess the effects of tobacco taxation, further tobacco marketing restrictions and mass communication strategies on smoking attitudes and behaviours. I will also extend the methods and measures I have developed in tobacco control to improve health communication in obesity prevention and alcohol harm prevention.