A Comparative Clinical Efficacy Trial Of Treatments For Melancholia
Funder
National Health and Medical Research Council
Funding Amount
$309,711.00
Summary
This study seeks to improve treatment of melancholic depression by comparing three treatments, i) a selective serotonin reuptake inhibitor (SSRI), ii) cognitive behaviour therapy (CBT) and, iii) a broad-spectrum antidepressant sequencing treatment approach. We hypothesize that the latter will be superior to both i) SSRI monotherapy, and ii) CBT monotherapy, over a 12-week trial period. Comparisons will be made with the US-based Sequenced Treatment Alternatives to Relieve Depression trial.
Identifying Strategies To Improve Perinatal Outcomes After Assisted Conception
Funder
National Health and Medical Research Council
Funding Amount
$724,799.00
Summary
Around 20% of young women express concern with being able to conceive, 16% experience clinical infertility, and ~8% use invasive therapies for which there can be limited safety data. We, and others, have reported adverse events for mother and child after infertility treatment, including neonatal death and birth defects. This project will provide urgently needed, robust evidence to guide patient and clinical decision making so as to optimise health of mother and baby.
Multiple sclerosis is the most common cause of neurological disability among young adults. The patients’ individual response to therapy is highly variable. The research vision completed during this Fellowship will generate novel evidence enabling individually-tailored therapy of multiple sclerosis. Through the newly established Clinical Outomes Research Unit at the Royal Melbourne Hospital, the expertise from observational data in multiple sclerosis will be applied in other areas of neurology.
Substantial portions of the Australian population have some difficulty walking. People affected include children with cerebral palsy, people who've had injuries playing sport and older people with Parkinson's disease, osteoarthritis or who have had a stroke. The cost of managing arthritic conditions alone was estimated at $2.2 Billion for 2001. Gait analysis uses high technology video cameras, force transducers, muscle activity sensors and computers to record how people walk and is now being use ....Substantial portions of the Australian population have some difficulty walking. People affected include children with cerebral palsy, people who've had injuries playing sport and older people with Parkinson's disease, osteoarthritis or who have had a stroke. The cost of managing arthritic conditions alone was estimated at $2.2 Billion for 2001. Gait analysis uses high technology video cameras, force transducers, muscle activity sensors and computers to record how people walk and is now being used more and more commonly across Australia. The technology is very similar to that now being used to capture how people move for the movie industry. The technology allows us a better understanding of how people are moving and therefore of what treatments they are likely to benefit from. Melbourne now has four Gait Analysis facilities working with different patient groups and each with an international reputation for its work. These groups have combined to form the CCRE in Gait Analysis and Gait Rehabilitation under the leadership of Professor H Kerr Graham (Royal Children's Hospital) and Professor Bob Iansek (Kingston Centre, Southern Health).Read moreRead less
Personalisation Of Aspirin Adjuvant Therapy In Patients With Colorectal Cancer
Funder
National Health and Medical Research Council
Funding Amount
$762,580.00
Summary
Aspirin use is associated with a reduced risk of bowel cancer recurrence. However, benefit appears limited to a subset of patients, and some individuals experience side effects. We will analyse tumour samples from patients participating in the ASCOLT clinical trial of aspirin to identify molecular features that can predict who will benefit from aspirin. Predictive biomarkers would be of substantial clinical utility for guiding treatment, minimising toxicity and improving disease outcomes.
Clinical Outcomes With Electroconvulsive Therapy: Insights From Computational Modelling
Funder
National Health and Medical Research Council
Funding Amount
$347,767.00
Summary
Electroconvulsive therapy (ECT) is the treatment of choice for severe, resistant depression. However it use is reduced by concerns about memory problems. The effectiveness and side effects of ECT depend on how it is given, but clinical trials can only test 1 variation at a time. This study will use sophisticated computational modelling to understand how varying the treatment approach affects clinical outcomes, allowing the development of next-generation, custom-designed ECT treatment.
ELders AT Ease Program (ELATE): A Cluster Randomised Controlled Trial Of A Sustainable And Scalable Mental Health Service For Australian Residential Aged Care Facilities
Funder
National Health and Medical Research Council
Funding Amount
$999,551.00
Summary
Elders living in residential facilities suffer significant levels of depression or anxiety. This study examines an innovative program to improve mental health of residents living in such facilities. The program involves counselling, staff training and family support. The study uses a cluster randomised controlled trial of facilities to evaluate the impact of ELATE: Elders at Ease Program” on residents’ psychological wellbeing, staff knowledge, family carer stress and, health care costs.
Standalone Internet Anxiety Treatment For Stuttering: A Randomised Trial
Funder
National Health and Medical Research Council
Funding Amount
$516,339.00
Summary
Anxiety-related mental health disorders, particularly social phobia, are common comorbid conditions among adults who stutter. This project establishes randomised controlled trial evidence for the psychological benefits of our Internet CBT treatment. This project also establishes whether our Internet CBT treatment reduces stuttering severity when combined with speech treatment. The design is an open plan, parallel, pragmatic randomised controlled trial.