Assessing the national productivity impacts of chronic ill health. The project aims to address one of the biggest gaps in health and productivity research by designing a novel composite national metric that will rank lost productivity due to chronic illness The project brings together tax/transfer modelling, health modelling and epidemiological modelling specialists to develop a highly innovative microsimulation model: Health&WorkMOD to then quantify the costs of health-related productivity loss ....Assessing the national productivity impacts of chronic ill health. The project aims to address one of the biggest gaps in health and productivity research by designing a novel composite national metric that will rank lost productivity due to chronic illness The project brings together tax/transfer modelling, health modelling and epidemiological modelling specialists to develop a highly innovative microsimulation model: Health&WorkMOD to then quantify the costs of health-related productivity loss. The proposed model, an international first, will be a powerful tool to comprehensively model the cost impacts of illness and simulate policy options related to health and productivity. This will provide answers to critical policy questions for government with potential significant economic benefits.Read moreRead less
Sparse grid approximations and fitting using generalised combination techniques. Sparse grid techniques provide an effective tool to deal with the
computational curse of dimensionality which is a constant challenge in
modelling complex data. The proposed research is aimed at the
development and analysis of algorithms for data fitting with sparse
grids using variants of the combination technique. The outcome of the
research is a theory which will provide insights in the applicability,
limit ....Sparse grid approximations and fitting using generalised combination techniques. Sparse grid techniques provide an effective tool to deal with the
computational curse of dimensionality which is a constant challenge in
modelling complex data. The proposed research is aimed at the
development and analysis of algorithms for data fitting with sparse
grids using variants of the combination technique. The outcome of the
research is a theory which will provide insights in the applicability,
limitations and the convergence properties of the proposed
algorithms. The outcomes will be widely applicable in modelling of
large scale and complex data as is encountered in areas of
bioinformatics, physics and experimental studies of complex systems.
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The economics of mothers milk and the market for infant food. Breastfeeding is increasingly recognized as an important public health issue, but is rarely viewed from an economic perspective. However, feminist critiques of mainstream economics have helped draw attention to the value of breastmilk and the significance of economic and commercial factors in women's decisions about infant feeding. This project aims to provide the economic analysis and social research relevant to effective public heal ....The economics of mothers milk and the market for infant food. Breastfeeding is increasingly recognized as an important public health issue, but is rarely viewed from an economic perspective. However, feminist critiques of mainstream economics have helped draw attention to the value of breastmilk and the significance of economic and commercial factors in women's decisions about infant feeding. This project aims to provide the economic analysis and social research relevant to effective public health policies on breastfeeding. The primary output will be a book manuscript.Read moreRead less
Resolving patients' complaints about hospitals: Responsive regulation by health ombudsmen. Ombudsmen help ensure integrity and accountability in societal institutions. This study of patients' complaints about hospitals to health ombudsmen in two states, and the responses of hospitals, will produce evidence on strategies for making hospitals more responsive to the public and more accountable for the quality of their care. Australia was a world leader in establishing health ombudsmen and this stud ....Resolving patients' complaints about hospitals: Responsive regulation by health ombudsmen. Ombudsmen help ensure integrity and accountability in societal institutions. This study of patients' complaints about hospitals to health ombudsmen in two states, and the responses of hospitals, will produce evidence on strategies for making hospitals more responsive to the public and more accountable for the quality of their care. Australia was a world leader in establishing health ombudsmen and this study will explore their impact upon the hospital system. Evidence-based strategies are needed to improve the accountability of service providers and regulators. Social and economic benefits flow from empowering patients and from improving hospital performance.Read moreRead less
Improving Government Policy Making and Needs-Based Delivery of Services: Innovative Techniques to Enhance Administrative Data by Adding Socioeconomic Status. This project will create major national benefits by illuminating whether there are significant differences in access to or usage of such key government services as health and education by socio-economic status. Currently, most departments do not fully exploit their administrative data to answer such questions, because of the difficulty of ....Improving Government Policy Making and Needs-Based Delivery of Services: Innovative Techniques to Enhance Administrative Data by Adding Socioeconomic Status. This project will create major national benefits by illuminating whether there are significant differences in access to or usage of such key government services as health and education by socio-economic status. Currently, most departments do not fully exploit their administrative data to answer such questions, because of the difficulty of identifying the socio-economic status of users. This project will help Australia in its on-going but recently intensified efforts to make better use of its administrative data, resulting in a more efficient use of our data resources; better targeting of scare government resources; and improved identification of those in greatest need. Read moreRead less
Chronic Disease Prevention and Treatment - Cost-Benefit Model Systems to Assist with Priority Setting. The key benefit of the proposal to develop linked chronic disease models that are able to account for comorbidities will be that a much more accurate picture of the health and financial implications of chronic diseases will be obtainable than with the traditional 'disease-by-disease' based studies. Such a global approach is particularly relevant to analysis of chronic disease prevention and/or ....Chronic Disease Prevention and Treatment - Cost-Benefit Model Systems to Assist with Priority Setting. The key benefit of the proposal to develop linked chronic disease models that are able to account for comorbidities will be that a much more accurate picture of the health and financial implications of chronic diseases will be obtainable than with the traditional 'disease-by-disease' based studies. Such a global approach is particularly relevant to analysis of chronic disease prevention and/or treatment, because the lifestyle related risk factors are common to many such diseases. Overall, the linked models will be able to improve on current decision making processes, providing a more complete view of chronic disease costs and benefits - either today, or in future - under different prevention or treatment scenarios.Read moreRead less
Creating the social genome: Advanced techniques for linking dynamic data. This project aims to develop novel efficient and effective models and techniques that enable record linkage of large dynamic databases while preserving the privacy of sensitive personal data. Social genomes are the digital footprints of our society. They are the basis of population informatics, which is revolutionising how researchers in various domains conduct studies, governments plan services and expenditures, and busin ....Creating the social genome: Advanced techniques for linking dynamic data. This project aims to develop novel efficient and effective models and techniques that enable record linkage of large dynamic databases while preserving the privacy of sensitive personal data. Social genomes are the digital footprints of our society. They are the basis of population informatics, which is revolutionising how researchers in various domains conduct studies, governments plan services and expenditures, and businesses advertise and interact with their customers. A core requirement of population informatics is the linking of large dynamic databases that contain details about people from diverse sources. The expected outcomes of this project will provide novel solutions to the challenges of population informatics faced by Australian organisations.Read moreRead less
A hierarchical quantum mechanical and classical simulation of biological ion channels. I aim to develop a methodology incorporating molecular quantum
mechanics and classical Brownian mechanics in a way that can be
applied practically to large macromolecular systems, thus relating
fine structural details to experimentally measurable
properties. Specifically, I will apply this methodology to study ion
channels in which the challenge is to relate electronic and atomic
structure to the conduct ....A hierarchical quantum mechanical and classical simulation of biological ion channels. I aim to develop a methodology incorporating molecular quantum
mechanics and classical Brownian mechanics in a way that can be
applied practically to large macromolecular systems, thus relating
fine structural details to experimentally measurable
properties. Specifically, I will apply this methodology to study ion
channels in which the challenge is to relate electronic and atomic
structure to the conductance properties of the channel. Accurately
determining these relationships provides a pathway to developing cures
for many neurological, cardiac, and muscular diseases.
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The Impact of International Trade Agreements on the Regulation and Provision of Medicines in Australia. This Project will provide policy makers and the community with previously unavailable detailed information and regulatory options (through scholarly publications, reports to government agencies and a publicly accessible website) concerning the effects of Australia's international trade commitments on access to medicines. It will develop a strategic modelling system and a continuing research gr ....The Impact of International Trade Agreements on the Regulation and Provision of Medicines in Australia. This Project will provide policy makers and the community with previously unavailable detailed information and regulatory options (through scholarly publications, reports to government agencies and a publicly accessible website) concerning the effects of Australia's international trade commitments on access to medicines. It will develop a strategic modelling system and a continuing research group with unique expertise for evaluating the health impacts of future trade negotiations by Australia and other nations. The Project particularly benefits aged and poor Australians who are more reliant on medicines for health and for whom such costs represent a significant component of domestic expenditure.Read moreRead less
Many Ys in monotremes: multiple sex chromosomes and sex determination in platypus and echidna. Platypus and Echidna are Australian icons, even featuring on our coins. Their unusual biology and ancient relationship to humans make them unique for understanding the mammalian genome, as demonstrated by our recent discovery of ten sex chromosomes in platypus that link mammal and bird sex. Still little is known about their genome, embryo development and how sex is determined. We will identify new gene ....Many Ys in monotremes: multiple sex chromosomes and sex determination in platypus and echidna. Platypus and Echidna are Australian icons, even featuring on our coins. Their unusual biology and ancient relationship to humans make them unique for understanding the mammalian genome, as demonstrated by our recent discovery of ten sex chromosomes in platypus that link mammal and bird sex. Still little is known about their genome, embryo development and how sex is determined. We will identify new genes on all ten sex chromosomes and investigate how they determine sex. The set up of an Australian Monotreme Resource Centre will be crucial for this research and attract worldwide high profile collaborations. We will answer important general questions in monotreme biology and contribute to our understanding of sexual abnormalities in humans.Read moreRead less