Development of therapeutic agents that target carbonic anhydrase enzymes. This research will discover new chemical entities (compounds) that may lead to therapies for the treatment of cancer, glaucoma and malaria. The research underpins a mechanism to add value to our compounds before partnering with industry to transform the discoveries made here to deliverable therapies that could benefit the health of millions, thus offering a potentially high value contribution to the Australian economy. The ....Development of therapeutic agents that target carbonic anhydrase enzymes. This research will discover new chemical entities (compounds) that may lead to therapies for the treatment of cancer, glaucoma and malaria. The research underpins a mechanism to add value to our compounds before partnering with industry to transform the discoveries made here to deliverable therapies that could benefit the health of millions, thus offering a potentially high value contribution to the Australian economy. The experience and commitment of the multi-disciplinary network of researchers offers exceptional training and employment opportunities for tomorrow's scientists in techniques for discovery and characterisation of novel chemicals, and their interaction with disease targets.Read moreRead less
Development of Multivalent Hyaluronan Derivative Therapeutics. Over-expression of the hyaluronan receptor CD44 has been identified at pathological sites of diseases such as cancer, psoriasis, arthritis and asthma. The research described in this proposal aims to develop novel therapeutic compounds which target CD44 whilst eliciting a therapeutic index. The design of these new therapeutics is based on a template structure which incorporates known cytotoxic or anti-fungal agentsas well as hyalu ....Development of Multivalent Hyaluronan Derivative Therapeutics. Over-expression of the hyaluronan receptor CD44 has been identified at pathological sites of diseases such as cancer, psoriasis, arthritis and asthma. The research described in this proposal aims to develop novel therapeutic compounds which target CD44 whilst eliciting a therapeutic index. The design of these new therapeutics is based on a template structure which incorporates known cytotoxic or anti-fungal agentsas well as hyaluronan, a naturally occurring carbohydrate, ubiquitous in nature.Read moreRead less
Development of carbohydrate-based drug delivery systems. Chronic skin disorders affect 5% of the population. Treatment is challenging and long term because these disorders are chronic and unpredictable. Currently the most potent therapies for psoriasis are administered systemically. Long term usage of these therapies causes side effects such as kidney or liver damage. This proposal describes a new approach to the topical treatment of psoriasis where potent drugs are linked to a hyaluronan sca ....Development of carbohydrate-based drug delivery systems. Chronic skin disorders affect 5% of the population. Treatment is challenging and long term because these disorders are chronic and unpredictable. Currently the most potent therapies for psoriasis are administered systemically. Long term usage of these therapies causes side effects such as kidney or liver damage. This proposal describes a new approach to the topical treatment of psoriasis where potent drugs are linked to a hyaluronan scaffold molecule and are directly applied to the diseased tissue. Advantages of this approach include targeted drug delivery mediated by hyaluronan receptor processes and potential amelioration of the observed drug toxicities.Read moreRead less