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Developing Drugs To Prevent Prostate Cancer Spread.
Funder
National Health and Medical Research Council
Funding Amount
$99,248.00
Summary
Current therapies for prostate cancer lose their efficacy as the cancer advances. Moreover, despite the spread of cancer being the major cause of prostate cancer mortality, there is no therapy available which selectively targets this process, thus new agents are needed. By using computer modelling to predict molecules that bind to the cell surface protein CD151 and testing these in biological assays, we aim to discover molecules that reduce cell migration of prostate cancer and that can be devel ....Current therapies for prostate cancer lose their efficacy as the cancer advances. Moreover, despite the spread of cancer being the major cause of prostate cancer mortality, there is no therapy available which selectively targets this process, thus new agents are needed. By using computer modelling to predict molecules that bind to the cell surface protein CD151 and testing these in biological assays, we aim to discover molecules that reduce cell migration of prostate cancer and that can be developed into anti-migration drugs.Read moreRead less
Cancer disparities exist between rural and metropolitan patients. Inferior survival outcomes are reported for rural residents, which can amount to a 7% difference in 5-year survival proportions. Factors implicated include: socio-economic disadvantage, limited access to specialist services, later diagnosis, and poorer treatment. Little is known about the decision-making process of patients. This research project examines patients’ preferences for cancer treatment, and whether there are difference ....Cancer disparities exist between rural and metropolitan patients. Inferior survival outcomes are reported for rural residents, which can amount to a 7% difference in 5-year survival proportions. Factors implicated include: socio-economic disadvantage, limited access to specialist services, later diagnosis, and poorer treatment. Little is known about the decision-making process of patients. This research project examines patients’ preferences for cancer treatment, and whether there are differences depending on geographical location.Read moreRead less
Understanding Influenza-specific T Cell Immunity In The Indigenous And Non-Indigenous Populations
Funder
National Health and Medical Research Council
Funding Amount
$49,202.00
Summary
Hospitalisation and mortality rates from influenza are high in the Indigenous population. There is an urgent need for one-shot universal vaccine that protects against seasonal and pandemic strains. To identify potential vaccine targets we firstly have to determine which viral proteins will induce a large protective immune response. These responses vary between ethnicities thus comparisons will be drawn between Indigenous and non-Indigenous Australians to determine multiple vaccine candidates tha ....Hospitalisation and mortality rates from influenza are high in the Indigenous population. There is an urgent need for one-shot universal vaccine that protects against seasonal and pandemic strains. To identify potential vaccine targets we firstly have to determine which viral proteins will induce a large protective immune response. These responses vary between ethnicities thus comparisons will be drawn between Indigenous and non-Indigenous Australians to determine multiple vaccine candidates that will be protective across ethnicities.Read moreRead less
Quantifying The Burden Of Systemic Sclerosis In Australia: From Data Linkage To Patient Reported Outcomes
Funder
National Health and Medical Research Council
Funding Amount
$81,976.00
Summary
Systemic sclerosis (SSc) is a rare autoimmune disease with the potential to cause significant physical, financial and psychosocial burden on patients, their family members and wider community. The true ‘burden’ of SSc in Australia is unknown. My study aims to quantify this burden of disease and use our results to advocate for appropriate allocation of resources with the ultimate goal of improving patient outcomes and reducing the financial and human costs of this chronic rare disease.
Gender As A Determinant Of Health – Consolidating The Evidence Base. An Analysis Of Gender Equity And Health Outcomes In Lower Income Countries, With A Focus On Maternal And Neonatal Mortality
Funder
National Health and Medical Research Council
Funding Amount
$122,714.00
Summary
Gender has been cited as a powerful influence on the extent and distribution of adverse health outcomes, especially maternal and neonatal mortality. It has been suggested that global health and development targets cannot be reached without adequate attention to gender equity. A strong evidence base is vital if gender is to be meaningfully considered in the post-2015 agenda. This thesis aims to extend this evidence base.
Often when people are sick they cannot communicate their wishes regarding medical decisions. This research will explore, through surveys and interviews, how older general practice patients understand these decisions and how their understanding compares with that of their loved ones and their general practitioner. We aim to provide an insight into the meaning people give to these decisions thereby assisting those who wish to plan for their future medical care and their doctors.
Improving Clinical Care In Patients With Cirrhosis
Funder
National Health and Medical Research Council
Funding Amount
$132,743.00
Summary
This PhD will evaluate the current state of cirrhosis care in Australia. Part one aims to determine the community prevalence of cirrhosis in a general practice cohort and assess the proportion of patients that have been already diagnosed. Part two will evaluate if patients with established compensated cirrhosis are receiving appropriate care and if not assess barriers to care. Part three will evaluate biomarkers to predict the risk of decompensation in patients with established cirrhosis.
Proactive Specialist Diabetes Inpatient Team To Improve Outcomes In Hospitalised Patients With Diabetes
Funder
National Health and Medical Research Council
Funding Amount
$124,761.00
Summary
Diabetes is a major epidemic in Australia. Current care of hospitalised patients with diabetes is complex, suboptimal and contributes to longer hospital stay, poor outcomes and strain on healthcare resources. This research aims to improve diabetes care in hospitalised patients by implementing a proactive specialist diabetes team that will autonomously identify and provide specialist care for these patients. The expected findings have potential to shape a new approach to hospital diabetes care.