Linkage Infrastructure, Equipment And Facilities - Grant ID: LE160100035
Funder
Australian Research Council
Funding Amount
$370,000.00
Summary
Advanced Nanomaterials Characterisation Facility. Advanced nanomaterials characterisation facility:
The integrated facility aims to provide precise characterisation of physicochemical properties of natural and engineered nanoparticles and their interaction with biological matrices. Such information would advance manufacturing, bioengineering, energy production, environmental and forensic science and nanomedicine.
Nanoengineering Smart and Precise Antimicrobial Polymers. Designing the next generation of antimicrobial polymers. This proposal aims to combat the critical global issue of antibiotic resistance via fundamental and innovative chemistry design solutions. The proposed new design will enable the polymers to activate intelligently and precisely in the presence of specific stimuli such as bacterial enzymes for the first time, thereby endowing the polymers with both antimicrobial and biocompatible pro ....Nanoengineering Smart and Precise Antimicrobial Polymers. Designing the next generation of antimicrobial polymers. This proposal aims to combat the critical global issue of antibiotic resistance via fundamental and innovative chemistry design solutions. The proposed new design will enable the polymers to activate intelligently and precisely in the presence of specific stimuli such as bacterial enzymes for the first time, thereby endowing the polymers with both antimicrobial and biocompatible properties. Both properties are crucially needed for successful translation into practical applications. This proposal will lead to new and effective avenues in fighting multidrug-resistant bacteria and will significantly benefit Australia's healthcare and agriculture sectors.Read moreRead less
The development of yoctowells on magnetic nanoparticles as both tiny chemical reactors and biological models. This project seeks to develop an innovative and cutting-edge research program in biomimicry by studying a surface functionalised system - the so called yoctowells - on magnetic nanoparticles, by studying their inclusion behaviour and utilising the intrinsic magnetic properties for isolation and manipulation in catalysis, medicine and electronics.
DNA printing on a synthetic polymer template. This project aims to design and study DNA printing to manufacture long strands of DNA using simple but elegant fundamental non-enzymatic chemical reactions. Gene therapy is one of the most rapidly growing therapies in modern medicine but it is prohibitively expensive for the average person. Current methods of artificial gene synthesis are complicated with commercial DNA synthesis only supplying short DNA strands. The project outcomes will lead to a s ....DNA printing on a synthetic polymer template. This project aims to design and study DNA printing to manufacture long strands of DNA using simple but elegant fundamental non-enzymatic chemical reactions. Gene therapy is one of the most rapidly growing therapies in modern medicine but it is prohibitively expensive for the average person. Current methods of artificial gene synthesis are complicated with commercial DNA synthesis only supplying short DNA strands. The project outcomes will lead to a stable template directing the chemical reactions for DNA printing. This new approach will make life-saving gene therapy cheaper and more widely available for future generations and provide economic, and social benefits to all Australians.Read moreRead less
Smart polymer-DNA hybrids as recognition sites for advanced DNA nanotechnology applications. This project aims to design and synthesise a new family of DNA-conjugated chain transfer agents for the positional control of DNA in a broad range of 2D and 3D 'smart' polymer-DNA hybrid materials. These bioconjugated materials will be investigated to understand the fundamental self-assembly processes which underpin emerging dynamic DNA nanotechnologies. This timely research will revolutionise the use of ....Smart polymer-DNA hybrids as recognition sites for advanced DNA nanotechnology applications. This project aims to design and synthesise a new family of DNA-conjugated chain transfer agents for the positional control of DNA in a broad range of 2D and 3D 'smart' polymer-DNA hybrid materials. These bioconjugated materials will be investigated to understand the fundamental self-assembly processes which underpin emerging dynamic DNA nanotechnologies. This timely research will revolutionise the use of biologically inspired intelligent metamaterials for use in medical diagnostics, DNA computing and DNA nanomachines.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE210100151
Funder
Australian Research Council
Funding Amount
$302,154.00
Summary
Near infrared imaging and spectroscopy facility. This project will establish a cutting-edge optical microscopy platform using light just beyond our vision, in the near-infrared. Recent developments in near-infrared camera technology have opened up new opportunities for applications in this under-explored spectral region. Expected outcomes include the development of new methods for harvesting near-infrared sunlight and for photocatalysis of solar fuels, new biomimetic coatings for thermal managem ....Near infrared imaging and spectroscopy facility. This project will establish a cutting-edge optical microscopy platform using light just beyond our vision, in the near-infrared. Recent developments in near-infrared camera technology have opened up new opportunities for applications in this under-explored spectral region. Expected outcomes include the development of new methods for harvesting near-infrared sunlight and for photocatalysis of solar fuels, new biomimetic coatings for thermal management, new security signatures invisible to the naked eye, new materials for phototherapy, and improved techniques for imaging biological samples. It will benefit Australian renewable energy, security, building, and biomedical industries, and train our next generation of optical science researchers.Read moreRead less
Unravelling the nanostructure of atmospheric black carbon. Black carbon is the second most important greenhouse forcing agent after carbon dioxide. The global atmospheric effect of black carbon predicted by current climate models is thought to be underestimated by at least 50 per cent, primarily due to uncertainties over the nature of black carbon and the absence of benchmarks. This project aims to use a computational chemistry approach to develop an atomistic model for black carbon. Using these ....Unravelling the nanostructure of atmospheric black carbon. Black carbon is the second most important greenhouse forcing agent after carbon dioxide. The global atmospheric effect of black carbon predicted by current climate models is thought to be underestimated by at least 50 per cent, primarily due to uncertainties over the nature of black carbon and the absence of benchmarks. This project aims to use a computational chemistry approach to develop an atomistic model for black carbon. Using these models, the project will determine the relationship between nanostructure and properties such as optical absorption and melting point.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE190100624
Funder
Australian Research Council
Funding Amount
$422,556.00
Summary
Bio-compartmentalised chemistry: controlling selectivity using encapsulins. This project aims to use Nature’s compartments (encapsulins) for use in synthetic chemistry. Controlling selectivity is a major challenge for synthetic chemists. In contrast, Nature has mastered the art of selectivity by using self-assembled compartments for important biochemical processes such as carbon fixation. The encapsulin-based platform technology resulting from this project will help address the problem of poor s ....Bio-compartmentalised chemistry: controlling selectivity using encapsulins. This project aims to use Nature’s compartments (encapsulins) for use in synthetic chemistry. Controlling selectivity is a major challenge for synthetic chemists. In contrast, Nature has mastered the art of selectivity by using self-assembled compartments for important biochemical processes such as carbon fixation. The encapsulin-based platform technology resulting from this project will help address the problem of poor selectivity in synthetic chemistry, leading to more energy efficient chemical processes. Adoption of these processes by industry is expected to translate into significant benefits for the economy and the environment.Read moreRead less
Beyond the exciton: shaping molecular energy landscapes using polaritons. This project aims to deliver a fundamental understanding of polariton-mediated light and heat energy transfer in molecular systems, paving the way for their exploitation in solar cells and chemical catalysis. Controlling energy flow within and between molecules is one of the challenges of molecular science. Such control allows concentration of light energy for solar harvesting and direction of thermal energy for site-selec ....Beyond the exciton: shaping molecular energy landscapes using polaritons. This project aims to deliver a fundamental understanding of polariton-mediated light and heat energy transfer in molecular systems, paving the way for their exploitation in solar cells and chemical catalysis. Controlling energy flow within and between molecules is one of the challenges of molecular science. Such control allows concentration of light energy for solar harvesting and direction of thermal energy for site-selective chemistry. Recent work shows that molecular polaritons, admixtures of light and molecules, are a new and unique tool to assert this control. This project aims to deliver genuinely disruptive improvements in solar cell efficiency using polaritons.Read moreRead less
Selective anion transporters with therapeutic potential. This project aims to develop compounds that can selectively facilitate the transport of anions such as chloride or bicarbonate across lipid bilayer membranes. Current generations of transporters have been shown to be un-selective, transporting protons, hydroxide or fatty acid head groups along with the anion of interest. New strategies will be developed to construct selective transporters including using encapsulating binding sites and d ....Selective anion transporters with therapeutic potential. This project aims to develop compounds that can selectively facilitate the transport of anions such as chloride or bicarbonate across lipid bilayer membranes. Current generations of transporters have been shown to be un-selective, transporting protons, hydroxide or fatty acid head groups along with the anion of interest. New strategies will be developed to construct selective transporters including using encapsulating binding sites and dynamic covalent approaches to binding to produce selective systems. These transporters have potential future application as electrophysiological tools to study lipid bilayer transport processes.Read moreRead less