The shock of the old: Rediscovering the sounds of bel canto 1700-1900. Bel canto—beautiful singing—describes a forgotten tradition (1700–1900), epitomising clear communication of expression and meaning of text. This project aims to generate new research-based knowledge of bel canto sound vocabulary, music, and history through implementation of a multi-modal method—working with an international community of singers—to produce multi-faceted outputs that inform future scholarship and creativity in ....The shock of the old: Rediscovering the sounds of bel canto 1700-1900. Bel canto—beautiful singing—describes a forgotten tradition (1700–1900), epitomising clear communication of expression and meaning of text. This project aims to generate new research-based knowledge of bel canto sound vocabulary, music, and history through implementation of a multi-modal method—working with an international community of singers—to produce multi-faceted outputs that inform future scholarship and creativity in singing. Modern classical singing fails to communicate the meaning of the text in bel canto repertory. Expected outcomes are revitalisation of global practices to produce classical singers better equipped to convey the text, increasing audience engagement, and the sustainability of the classical music industry.Read moreRead less
Art and Cultural Exchange at the Strait of Gibraltar. The project aims to give a first-time analysis of visual culture at the Strait of Gibraltar. It asks how painting, photography, film, and maps relate to colonial expansion, with a focus on Australian, French and Spanish involvement in the Western Mediterranean. The British fortress-colony of Gibraltar and the international Moroccan port of Tangier have never before been subject to comparative analysis. Key outcomes include two major exhibit ....Art and Cultural Exchange at the Strait of Gibraltar. The project aims to give a first-time analysis of visual culture at the Strait of Gibraltar. It asks how painting, photography, film, and maps relate to colonial expansion, with a focus on Australian, French and Spanish involvement in the Western Mediterranean. The British fortress-colony of Gibraltar and the international Moroccan port of Tangier have never before been subject to comparative analysis. Key outcomes include two major exhibitions, one on Australian Orientalism at the National Gallery and the second on historical art in the region. By shedding historical light on people smuggling, contraband and post-Brexit identity at the Strait, the project aims to generate cultural knowledge pertinent to international co-operation.Read moreRead less
Heritage in the limelight: the magic lantern in Australia and the world. The project aims to discover and analyse the large number of glass magic lantern slides that remain under-used in our public collections. International scholarship has recently begun to show that lantern slide shows were a ubiquitous, globalised and formative cultural experience. The project aims to explore the international reach and diversity of this globalised modernist apparatus from the Australian perspective. It plans ....Heritage in the limelight: the magic lantern in Australia and the world. The project aims to discover and analyse the large number of glass magic lantern slides that remain under-used in our public collections. International scholarship has recently begun to show that lantern slide shows were a ubiquitous, globalised and formative cultural experience. The project aims to explore the international reach and diversity of this globalised modernist apparatus from the Australian perspective. It plans to understand how diverse audiences affectively experienced these powerful forms of early media, and to develop ways for today’s Australians to re-experience their magic, invigorating and expanding our cultural heritage.Read moreRead less
Performing transdisciplinarity. This project aims to use the illustrated songbook, a performative genre which fuses image, music and text, to study the transdisciplinary nature of 18th-century print culture. Through multifaceted research on an exemplary songbook, this project will create a multimedia digital interface for linking deep disciplinary knowledge and the recreation of the sounds, sensibilities, and social mores of 18th-century France. The project's model of rich digital understanding ....Performing transdisciplinarity. This project aims to use the illustrated songbook, a performative genre which fuses image, music and text, to study the transdisciplinary nature of 18th-century print culture. Through multifaceted research on an exemplary songbook, this project will create a multimedia digital interface for linking deep disciplinary knowledge and the recreation of the sounds, sensibilities, and social mores of 18th-century France. The project's model of rich digital understanding has potential benefits for cultural institutions whose complex objects lie dormant or underused.Read moreRead less
Novel statistical methods for data with non-Euclidean geometric structure. This project aims to develop new flexible regression models and classification algorithms, along with robust and efficient inference methods, applicable to a wide range of non-Euclidean data types which arise in many fields of science, business and technology. There are serious flaws with currently available methods of analysis for non-Euclidean data. This project expects to transform such analyses by providing new quanti ....Novel statistical methods for data with non-Euclidean geometric structure. This project aims to develop new flexible regression models and classification algorithms, along with robust and efficient inference methods, applicable to a wide range of non-Euclidean data types which arise in many fields of science, business and technology. There are serious flaws with currently available methods of analysis for non-Euclidean data. This project expects to transform such analyses by providing new quantitative tools within a unifying framework. The anticipated project outcomes will be of mathematical interest and valuable in applications such as finance (predicting Australian stock returns); modelling electroencephalography data; Australian geochemical data, relating to sediments; and Australian X-ray tumour image data. Read moreRead less
Guiding principles and guardrails for genetic association studies. This project aims to investigate deep connections between genetic structure (population genetic processes, linkage disequilibrium and population structure) and the ability to statistically detect genetic variants responsible for variation in traits. The project expects to generate new knowledge in the areas of statistics, mathematics and biology through an innovative, multidisciplinary approach that synthesises and extends founda ....Guiding principles and guardrails for genetic association studies. This project aims to investigate deep connections between genetic structure (population genetic processes, linkage disequilibrium and population structure) and the ability to statistically detect genetic variants responsible for variation in traits. The project expects to generate new knowledge in the areas of statistics, mathematics and biology through an innovative, multidisciplinary approach that synthesises and extends foundational disciplinary results. Expected outcomes of this project include principles and methodology that underpin future genetic association studies by supplying a framework for interpreting results. This should provide significant benefits by reducing false conclusions and their associated costs.Read moreRead less
Bayesian inversion and computation applied to atmospheric flux fields. This project aims to make use of unprecedented sources of measurements, from remote sensing and in situ data, to estimate the sources and sinks of greenhouse gases. An overabundance of greenhouse gases in Earth's atmosphere is arguably the most serious long-term threat to the planet's ecosystems. This project will combine measurement uncertainties, process uncertainties in the physical transport models, and any parameter unce ....Bayesian inversion and computation applied to atmospheric flux fields. This project aims to make use of unprecedented sources of measurements, from remote sensing and in situ data, to estimate the sources and sinks of greenhouse gases. An overabundance of greenhouse gases in Earth's atmosphere is arguably the most serious long-term threat to the planet's ecosystems. This project will combine measurement uncertainties, process uncertainties in the physical transport models, and any parameter uncertainties, to provide reliable uncertainty quantification for the estimates. This will be achieved with new Bayesian spatio-temporal inversions and big-data computational strategies. The resulting statistical inferences on greenhouse-gas flux fields will enable the development of critical mitigation strategies. These new statistical inferences will be a valuable resource to policy-makers worldwide, who are assessing progress towards global commitments. Further, the final product may assist in developing cost-effective mitigation strategies in the presence of uncertainty.Read moreRead less
Molecular mechanisms of mechanosensation and shape regulation in cells. This project aims to explore how cells physically sense and respond to the surrounding environment on a molecular level. Physical distortion of erythrocytes doubles their glucose consumption and increases cation membrane flux five-fold. This mechanism involves opening of the mechanosenstive ion channel Piezo1. This project will include a kinetic description of these phenomena, with a goal to establish a predictive mathematic ....Molecular mechanisms of mechanosensation and shape regulation in cells. This project aims to explore how cells physically sense and respond to the surrounding environment on a molecular level. Physical distortion of erythrocytes doubles their glucose consumption and increases cation membrane flux five-fold. This mechanism involves opening of the mechanosenstive ion channel Piezo1. This project will include a kinetic description of these phenomena, with a goal to establish a predictive mathematical model of the regulation of cell-shape and volume. The project will provide an understanding of mechanisms operating when cells and tissues are succumbing to trauma and invasion, and how to control these processes on a molecular level.Read moreRead less
Star Formation Through Cosmic Time. This project aims to determine how turbulence and magnetic fields control the formation of stars. This is crucial to understand the formation of galaxies, planets and ultimately life. The expected outcomes are the most detailed simulations of star formation in the early Universe and in galaxies today. This project has the potential to transform our understanding of cosmic structure formation, providing crucial input for Australian and international facilities ....Star Formation Through Cosmic Time. This project aims to determine how turbulence and magnetic fields control the formation of stars. This is crucial to understand the formation of galaxies, planets and ultimately life. The expected outcomes are the most detailed simulations of star formation in the early Universe and in galaxies today. This project has the potential to transform our understanding of cosmic structure formation, providing crucial input for Australian and international facilities and surveys, and models of galaxy, star and planet formation. Training Australia's future generation of Big Data analysts, as well as the development of interdisciplinary tools involving Chemical Modelling, Plasma Physics, Statistics and High Performance Computing are key benefits.Read moreRead less
Eradicating bacterial biofilms with nitroxide-antimicrobial hybrids. This project aims to develop new antimicrobials to address the rise of drug-resistant infections and resilient bacterial communities called biofilms. We aim to break new ground in our fundamental knowledge of antimicrobial mechanisms and exploit this understanding by fusing cellular/molecular microbiology and synthetic chemistry approaches. We seek to gain an in-depth understanding of how nitroxides induce bacterial biofilm dis ....Eradicating bacterial biofilms with nitroxide-antimicrobial hybrids. This project aims to develop new antimicrobials to address the rise of drug-resistant infections and resilient bacterial communities called biofilms. We aim to break new ground in our fundamental knowledge of antimicrobial mechanisms and exploit this understanding by fusing cellular/molecular microbiology and synthetic chemistry approaches. We seek to gain an in-depth understanding of how nitroxides induce bacterial biofilm dispersal, which is critical for the discovery of anti-biofilm molecules that do not fail due to resistance development. These breakthroughs should induce a step-change in our ability to reduce the occurrence of biofilm-related infection in fields ranging from medical and veterinary to biotechnology and agriculture.Read moreRead less