Linkage Infrastructure, Equipment And Facilities - Grant ID: LE240100063
Funder
Australian Research Council
Funding Amount
$1,900,000.00
Summary
Scanning Transmission Electron Microscope for Beam-Sensitive Materials. This project aims to establish a transmission electron microscopy facility for the high-throughput characterisation of delicate materials, at the atomic scale and a broad range of temperatures. Unique in Australia, this capability will enable the location and type of atoms critical to materials properties to be determined for materials as diverse as lithium-bearing minerals, next-generation solar cells and drug-delivery agen ....Scanning Transmission Electron Microscope for Beam-Sensitive Materials. This project aims to establish a transmission electron microscopy facility for the high-throughput characterisation of delicate materials, at the atomic scale and a broad range of temperatures. Unique in Australia, this capability will enable the location and type of atoms critical to materials properties to be determined for materials as diverse as lithium-bearing minerals, next-generation solar cells and drug-delivery agents. In this way it will foster the engineering of new materials for addressing current challenges in energy, environment, transport, health and manufacturing. This will be a national, open access facility for use by research institutions and industry, and for training the next generation of postgraduate students.Read moreRead less
Biophysics of the brain’s waste disposal system: Understanding why we sleep. This project aims to develop a new biophysical model of the brain, founded on the recently discovered glymphatic system responsible for waste disposal during sleep. It sets out to formulate, analyse, and validate rigorous new multiscale quantitative modelling – to advance the study of sleep and brain clearance dynamics, at timescales from hours to decades. Among expected outcomes are powerful models ready for applicatio ....Biophysics of the brain’s waste disposal system: Understanding why we sleep. This project aims to develop a new biophysical model of the brain, founded on the recently discovered glymphatic system responsible for waste disposal during sleep. It sets out to formulate, analyse, and validate rigorous new multiscale quantitative modelling – to advance the study of sleep and brain clearance dynamics, at timescales from hours to decades. Among expected outcomes are powerful models ready for application at both population and individual level, and testable predictions concerning the sleep patterns that lead to aggregation of waste in the brain and eventual cognitive decline. Project outcomes should also benefit society and the economy though translation into interventions for sleep disturbance – in future applied research.Read moreRead less
Diamane: A New Frontier in Materials Science. Single-layer diamond (‘diamane’) is a new frontier of material research although its preparation is still in infancy with many structures predicted possible but have not been made experimentally. Built on a new chemical route for 'graphite to diamane' transformation, this project will address a research gap towards synthesising new diamane(-like) nanostructures and developing an in-depth understanding of the chemically induced phase transformation an ....Diamane: A New Frontier in Materials Science. Single-layer diamond (‘diamane’) is a new frontier of material research although its preparation is still in infancy with many structures predicted possible but have not been made experimentally. Built on a new chemical route for 'graphite to diamane' transformation, this project will address a research gap towards synthesising new diamane(-like) nanostructures and developing an in-depth understanding of the chemically induced phase transformation and structure-property correlations, which will have far-reaching impact on scientific fields beyond carbon research. Preliminary data points to both feasibility and impact for discovering new materials and technologies, which will bring foreseeable scholarly, economic, and social benefits.Read moreRead less
Nanoengineered hybrid coatings that control inflammation to artificial bone. This project aims to develop novel biocompatible surfaces using nanotechnology approaches to understand how cells attach to and grow on artificial bone materials. This research is significant because it combines novel nanofabrication and surface modification strategies for unprecedented control and manipulation of inflammatory cell behaviour relevant to orthopaedic implants. The project will overcome current limitations ....Nanoengineered hybrid coatings that control inflammation to artificial bone. This project aims to develop novel biocompatible surfaces using nanotechnology approaches to understand how cells attach to and grow on artificial bone materials. This research is significant because it combines novel nanofabrication and surface modification strategies for unprecedented control and manipulation of inflammatory cell behaviour relevant to orthopaedic implants. The project will overcome current limitations of uncontrollable inflammatory reactions to surfaces. The multifunctional surfaces are expected to give the biomaterials field new tools to control and maintain bone cell functionality, in vitro. Potential long-term benefits include applications as coatings in tissue engineering, regenerative medicine, and medical implants.Read moreRead less
Viral capsids as high-efficiency nanoreactors. This project aims to develop state-of-the-art single-molecule imaging to visualise DNA synthesis inside authentic retroviral capsids in real time. The project expects to generate new knowledge in the fields of virology, synthetic biology, and nanotechnology by utilising cutting-edge fluorescent labelling reagents and microscopy technology. Expected outcomes include a comprehensive description of retrovirus reverse transcription, development of innov ....Viral capsids as high-efficiency nanoreactors. This project aims to develop state-of-the-art single-molecule imaging to visualise DNA synthesis inside authentic retroviral capsids in real time. The project expects to generate new knowledge in the fields of virology, synthetic biology, and nanotechnology by utilising cutting-edge fluorescent labelling reagents and microscopy technology. Expected outcomes include a comprehensive description of retrovirus reverse transcription, development of innovative biophysical techniques for the study of viruses, and an understanding of the engineering principles at play in natural nano-reactors. This project anticipates contributing advanced capabilities in bionanotechnology, benefiting therapeutic, biotechnology and synthetic biology applications.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE240100054
Funder
Australian Research Council
Funding Amount
$1,341,398.00
Summary
Dedicated High-throughput 3D-Electron Diffractometer. This proposal aims to install the first dedicated high-throughput 3D-electron diffractometer in the Southern Hemisphere, and one of the first in the world. It will be able to rapidly solve the atomic-scale structures of molecules and materials for which this is now extremely difficult and time-consuming – or impossible – due to the inability to grow large enough crystals for traditional X-ray diffraction. It will thus provide a significant ad ....Dedicated High-throughput 3D-Electron Diffractometer. This proposal aims to install the first dedicated high-throughput 3D-electron diffractometer in the Southern Hemisphere, and one of the first in the world. It will be able to rapidly solve the atomic-scale structures of molecules and materials for which this is now extremely difficult and time-consuming – or impossible – due to the inability to grow large enough crystals for traditional X-ray diffraction. It will thus provide a significant advantage for chemists, physicists, biologists, geologists, and engineers who rely on detailed structural knowledge to rationally optimise the properties of their compounds, from pharmaceutical activity to carbon capture to superconductivity, to the substantial benefit of multiple national priority areas.Read moreRead less
On the Combustion of Green Hydrogen in Future Energy Systems. This project aims to address key fundamental issues that will facilitate the combustion of hydrogen-based fuels for power and mobility. This is achieved by applying advanced laser diagnostics and novel computational methods to turbulent flames of hydrogen fuel blends hence generating new physical knowledge and predictive models. These will provide engineers with essential tools to design and operate fuel-flexible energy systems that s ....On the Combustion of Green Hydrogen in Future Energy Systems. This project aims to address key fundamental issues that will facilitate the combustion of hydrogen-based fuels for power and mobility. This is achieved by applying advanced laser diagnostics and novel computational methods to turbulent flames of hydrogen fuel blends hence generating new physical knowledge and predictive models. These will provide engineers with essential tools to design and operate fuel-flexible energy systems that speed up the critical transition towards employing green hydrogen. Expected outcomes include novel experimental methods and databases, reliable software, and graduates capable of facilitating this transition and accelerating the global decarbonization process while positioning Australia as a hydrogen superpower.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE230101021
Funder
Australian Research Council
Funding Amount
$435,000.00
Summary
Developing tunable nanoporous graphene membranes for resource recovery. This project aims to advance the development of atom-thick nanoporous graphene molecular filters (membranes) to tackle challenging separations in the chemical industry and open new pathways to recover valuable materials from waste streams. The extreme thinness of these membranes allows them to separate molecules with a fraction of the energy typically used by commercially available technologies. The proposed electrochemical ....Developing tunable nanoporous graphene membranes for resource recovery. This project aims to advance the development of atom-thick nanoporous graphene molecular filters (membranes) to tackle challenging separations in the chemical industry and open new pathways to recover valuable materials from waste streams. The extreme thinness of these membranes allows them to separate molecules with a fraction of the energy typically used by commercially available technologies. The proposed electrochemical platform is expected to fabricate and operate fit-for-purpose membranes with unprecedented control. Significant new knowledge in the areas of material engineering, nanofluidics, and membranes is expected from exploiting this platform to study ion transport under confinement and make membranes for resource recovery.Read moreRead less
New techniques and invariants in low-dimensional topology. The aim of this project is to introduce and apply new methods and invariants in the field of low-dimensional topology by developing parametrised and equivariant enhancements of Seiberg-Witten theory and Floer homology. These new refined invariants, made possible by recent advances in gauge theory, will be more powerful than existing ones, enabling the detection of new exotic phenomena. Expected outcomes include effective means for distin ....New techniques and invariants in low-dimensional topology. The aim of this project is to introduce and apply new methods and invariants in the field of low-dimensional topology by developing parametrised and equivariant enhancements of Seiberg-Witten theory and Floer homology. These new refined invariants, made possible by recent advances in gauge theory, will be more powerful than existing ones, enabling the detection of new exotic phenomena. Expected outcomes include effective means for distinguishing families of spaces, measuring their complexity and new obstructions for their existence. The new invariants and techniques will lead to the resolution of some open problems in low-dimensional topology and enhance Australia's reputation as a world leader in this field.Read moreRead less
Atomic-Scale Engineering of Bioactive Organic Molecules on Surfaces. Advances in scanning probe microscopy (SPM) have enabled the precise engineering of matter at surfaces. The ability to image and track changes at surfaces is simply staggering, but the frontier of molecules with pharmaceutical and agrichemical importance remains unexplored. This interdisciplinary project aims to synthesise fundamental molecules and reveal molecular rearrangement pathways utilising SPM. Expected outcomes of this ....Atomic-Scale Engineering of Bioactive Organic Molecules on Surfaces. Advances in scanning probe microscopy (SPM) have enabled the precise engineering of matter at surfaces. The ability to image and track changes at surfaces is simply staggering, but the frontier of molecules with pharmaceutical and agrichemical importance remains unexplored. This interdisciplinary project aims to synthesise fundamental molecules and reveal molecular rearrangement pathways utilising SPM. Expected outcomes of this project include new methods to couple molecules otherwise unobtainable by traditional means and fundamental knowledge of molecular manipulation and chemical structure. This aims to provide significant benefits, such as the translation of new chemical principles to academic and industrial laboratories.Read moreRead less