Linkage Infrastructure, Equipment And Facilities - Grant ID: LE130100061
Funder
Australian Research Council
Funding Amount
$710,000.00
Summary
Extending frontiers of structural chemistry and biology through high resolution pulsed Electron Paramagnetic Resonance. Multifrequency high resolution pulsed Electron Paramagnetic Resonance (EPR) instrumentation will provide forefront technologies in identifying, characterising, quantifying and visualising free radicals and metal ions that are involved in fundamental chemical and biological processes in science and nature.
Unravelling the structural complexity of ancient Australian arthropod venoms. Animal venoms contain a complex mix of molecules that have evolved over millions of years to target various biological processes. Their exquisite specificity and potent activity has made them an attractive source for development as therapeutic drugs with fewer side effects or as environmentally friendly insecticides. This project aims to for the first time explore the three-dimensional structure of all known classes of ....Unravelling the structural complexity of ancient Australian arthropod venoms. Animal venoms contain a complex mix of molecules that have evolved over millions of years to target various biological processes. Their exquisite specificity and potent activity has made them an attractive source for development as therapeutic drugs with fewer side effects or as environmentally friendly insecticides. This project aims to for the first time explore the three-dimensional structure of all known classes of toxins in the venom of two ancient Australian arthropods (spiders and centipedes). This will provide a comprehensive overview of these venoms and provide opportunities in engineering new classes of venom based drugs and insecticides. Read moreRead less
Automated structural analysis of proteins by nuclear magnetic resonance (ASAP-NMR): a leap forward in structural studies of proteins using NMR spectroscopy. Proteins form the machinery that makes life possible, and this research will revolutionise study of their three-dimensional structure by making the process faster and cheaper. This approach will be applied to study proteins isolated from animal venoms in order to identify and develop novel pharmaceuticals and bio-insecticides.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE140100162
Funder
Australian Research Council
Funding Amount
$300,000.00
Summary
Ultrafast Science Facility: manipulating and probing matter on fs timescales with microscopic resolution. Ultrafast science facility: manipulating and probing matter on femtosecond timescales with microscopic resolution: Knowledge of dynamics that occur on femtosecond timescales is essential for a detailed understanding of many important processes in physics, chemistry and biology. This facility will enable unprecedented insight into the mechanisms driving such processes through complementary ca ....Ultrafast Science Facility: manipulating and probing matter on fs timescales with microscopic resolution. Ultrafast science facility: manipulating and probing matter on femtosecond timescales with microscopic resolution: Knowledge of dynamics that occur on femtosecond timescales is essential for a detailed understanding of many important processes in physics, chemistry and biology. This facility will enable unprecedented insight into the mechanisms driving such processes through complementary capabilities to manipulate and probe matter on femtosecond time scales at microscopic resolution. Such processes include photosynthetic energy transfer, efficient operation of organic electronics, redox reactions in biological systems and the manipulation of material properties by intense femtosecond-laser pulses. The unique capabilities of this facility will also allow the development of novel device structures and the limits of the characterisation techniques to be pushed.Read moreRead less
Rapid, ultra-sensitive protein structure elucidation by mass spectrometry. This project seeks to develop a method for rapidly discovering classes of molecules that bind to unique sites on proteins. The development of new pharmaceuticals is frequently delayed by the time and resources required to identify the sites that new chemical entities bind to protein targets. A recent discovery has resulted in the ability to completely characterise large protein sequences directly from single mass spectra. ....Rapid, ultra-sensitive protein structure elucidation by mass spectrometry. This project seeks to develop a method for rapidly discovering classes of molecules that bind to unique sites on proteins. The development of new pharmaceuticals is frequently delayed by the time and resources required to identify the sites that new chemical entities bind to protein targets. A recent discovery has resulted in the ability to completely characterise large protein sequences directly from single mass spectra. This project aims to leverage this breakthrough by developing a rapid new approach for revealing ligand-protein binding sites using whole-protein mass spectrometry. This would enable novel sites of interactions between molecules and protein targets to be discovered rapidly with high sensitivity. In turn, this would allow the efficient design of next-generation classes of bioactive molecules.Read moreRead less
Quantitative multidimensional optical spectroscopy: revealing dynamics and structure in complex condensed matter systems. Understanding how quantum mechanics affects photosynthesis and how it can cause interactions between distant nanostructures are intriguing problems that may be of great significance for future smart technologies. This project will gain unprecedented insight into these processes using a novel technique to identify and resolve the mechanisms responsible.
Elucidation of structure-function relationships in biological systems utilising advanced electron spin resonance. The human growth hormone receptor and mammalian P450 enzymes are implicated in numerous human disorders and the key to treatment is the rational design and delivery of drugs. This project will require a comprehensive understanding of the biological structure-function relationship which we will acquire using high-resolution electron spin resonance spectroscopy.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE140100122
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Microdiffraction: Advanced capabilities for spatial resolution, trace phase detection and solid object analysis. Microdiffraction: advanced capabilities for spatial resolution, trace phase detection and solid object analysis: Microdiffraction offers two principal capacities that traditional powder diffraction (PD) facilities cannot: it enables small areas to be examined on a spatially resolved basis enabling identification, and it enables analysis of minor, but frequently crucial phases and anal ....Microdiffraction: Advanced capabilities for spatial resolution, trace phase detection and solid object analysis. Microdiffraction: advanced capabilities for spatial resolution, trace phase detection and solid object analysis: Microdiffraction offers two principal capacities that traditional powder diffraction (PD) facilities cannot: it enables small areas to be examined on a spatially resolved basis enabling identification, and it enables analysis of minor, but frequently crucial phases and analysis of samples that are not in a powder form thus enabling non-destructive examination. These capabilities provide powerful complementary capacity to existing SEM, QEM-SCAN, ToF-SIMS and PD facilities. Potential and existing applications are numerous and include minerals analyses; forensic applications; micro-electronics; corrosion analyses; art analysis/conservation; archaeology; materials; polymers; thin films; dielectric properties; liquid crystals; and drug characterisation.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE120100012
Funder
Australian Research Council
Funding Amount
$230,000.00
Summary
Enhanced powder X-ray diffraction capabilities for South Australia. This X-ray diffraction facility will provide structural information on the properties of novel materials which is important for investigations ranging from post-combustion carbon dioxide capture through to the identification of new mineralogical samples. Rapid, local access to this integrated facility will position South Australian researchers to make breakthroughs that benefit Australia.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE110100137
Funder
Australian Research Council
Funding Amount
$250,000.00
Summary
Femtosecond broad wavelength range laser facility. This facility will provide a unique source of ultra-short laser pulses spanning the X-ray to the infrared regions. It will provide a powerful coherent X-ray source that will position Australia at the forefront of coherent imaging science and the ability to perform ultrafast infrared spectroscopic measurements.