Elastic and biodegradable sponges/aerogels from exfoliated silk nanofibres . The aim of this project is to investigate methods to produce highly porous elastic sponges from silk protein nanofibres. These sponges will have optimal mechanical, insulation and degradation properties making them suitable for a wide range of applications including the biomedical and personal care sectors, where current products have significant drawbacks due to the use of non-biodegradable synthetic materials. Outco ....Elastic and biodegradable sponges/aerogels from exfoliated silk nanofibres . The aim of this project is to investigate methods to produce highly porous elastic sponges from silk protein nanofibres. These sponges will have optimal mechanical, insulation and degradation properties making them suitable for a wide range of applications including the biomedical and personal care sectors, where current products have significant drawbacks due to the use of non-biodegradable synthetic materials. Outcomes include new knowledge on controlling porous structures and tailoring properties to targeted applications. This project, by laying the groundwork for a new generation of bio-based materials, will benefit the Australian advanced manufacturing sector, and enhance Australia's standing in materials science and engineering.Read moreRead less
The true potential and limitations of fibres. This project aims to understand the fibre spinning process of nanomaterials to identify their true potential and limitations in wearable applications. The project is expected to lead to multifunctional materials that allow design and production of smart functional fibres and textiles that store and convert energy and sense, monitor and respond to human activities and external environments. The project outcomes are expected to accelerate the transform ....The true potential and limitations of fibres. This project aims to understand the fibre spinning process of nanomaterials to identify their true potential and limitations in wearable applications. The project is expected to lead to multifunctional materials that allow design and production of smart functional fibres and textiles that store and convert energy and sense, monitor and respond to human activities and external environments. The project outcomes are expected to accelerate the transformation of the fibre industry, which will have far reaching implications across research disciplines and sectors critical to technology, health, social, and economic future.Read moreRead less
Understanding the composite structures and properties of wild silk cocoons. This project will reveal the secret of wild silk cocoon structures, which are very thin and light in weight, yet they can protect wild silkworms in very harsh environments. This new knowledge will lead to the development of nature inspired materials and structures for personal protection.
Short silk nanofibre based 3D scaffolds with enhanced biomimicry. This project aims to understand the behaviour of haematopoietic stem cells (HSC) in novel 3D scaffolds based on short silk nanofibres. This will lead to highly functional 3D scaffolding materials that support efficient HSC renewal in vitro. This project aims to overcome the key problem with existing in vitro systems, which lack the morphological and biochemical complexities of native HSC-niche. Since haematopoietic stem cells are ....Short silk nanofibre based 3D scaffolds with enhanced biomimicry. This project aims to understand the behaviour of haematopoietic stem cells (HSC) in novel 3D scaffolds based on short silk nanofibres. This will lead to highly functional 3D scaffolding materials that support efficient HSC renewal in vitro. This project aims to overcome the key problem with existing in vitro systems, which lack the morphological and biochemical complexities of native HSC-niche. Since haematopoietic stem cells are the precursors to all blood cells, this project has the potential of engineering a high yield artificial ‘blood factory’, which will help save the lives of many thousands of people who rely on bone marrow transplants to treat life-threatening illness such as leukaemia.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE170100068
Funder
Australian Research Council
Funding Amount
$390,000.00
Summary
Bioinspired liposome-based smart sensors. This project aims to develop a liposome-based biosensor technology that mimics cell sensory systems. Selective detection of compounds is increasingly important for food, health and environmental monitoring. Biosensor development faces long-standing challenges such as response time, sensitivity, specificity, and multiplexing. On the other hand, cells can sense and discriminate multiple biomolecules in seconds with high sensitivity and specificity. This pr ....Bioinspired liposome-based smart sensors. This project aims to develop a liposome-based biosensor technology that mimics cell sensory systems. Selective detection of compounds is increasingly important for food, health and environmental monitoring. Biosensor development faces long-standing challenges such as response time, sensitivity, specificity, and multiplexing. On the other hand, cells can sense and discriminate multiple biomolecules in seconds with high sensitivity and specificity. This project aims to harness cells’ exquisite biological properties to improve current detection techniques. It will integrate liposome-based sensors with microfluidics to perform analytical tasks ranging from food safety to diagnostics.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE130100800
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Polymer micropatches applied to the skin for integrated capture and detection of circulating biomarkers. The purpose of this project is to develop a rapid and integrated technology for user-friendly biomarker detection at the point-of-care. We expect the device to rapidly detect proteins and/or antibodies, without the need for highly trained health workers or access to scientific laboratories.
Improving road safety: advanced hybrid vehicle-based technology for monitoring driver drowsiness. Innovative technology geared towards reducing road accidents and fatalities (for improving public health) will constitute major socio-economic benefit to Australia. The Australian Transport Safety Bureau notes fatigue as a major cause of road accidents (2006). The World Health Organisation dedicated World Health Day 2004 to road safety and emphasized the importance of combating fatigue ('Road Safety ....Improving road safety: advanced hybrid vehicle-based technology for monitoring driver drowsiness. Innovative technology geared towards reducing road accidents and fatalities (for improving public health) will constitute major socio-economic benefit to Australia. The Australian Transport Safety Bureau notes fatigue as a major cause of road accidents (2006). The World Health Organisation dedicated World Health Day 2004 to road safety and emphasized the importance of combating fatigue ('Road Safety is no Accident'). This research will develop an innovative driver drowsiness detecting technology. With drowsiness attributable to substantial road fatalities, this technology aims to reduce this emotional and socio-economic burden on the community, contributing to national and community benefit by providing a safer road environment.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE140101056
Funder
Australian Research Council
Funding Amount
$380,156.00
Summary
Rational Design of Plasmonic Nanoassemblies for Rapid and Multiplexed Point-of-Care Diagnosis by Surface-enhanced Raman Spectroscopy (SERS). The central aim of this project is to develop a novel technology/sensor platform for rapid, quantitative, multiplexed and highly sensitive point-of-care diagnostics using surface-enhanced Raman spectroscopy (SERS) as the read-out approach. Three-dimensional plasmonic superstructures as novel SERS labels will be synthesised and characterised at single-partic ....Rational Design of Plasmonic Nanoassemblies for Rapid and Multiplexed Point-of-Care Diagnosis by Surface-enhanced Raman Spectroscopy (SERS). The central aim of this project is to develop a novel technology/sensor platform for rapid, quantitative, multiplexed and highly sensitive point-of-care diagnostics using surface-enhanced Raman spectroscopy (SERS) as the read-out approach. Three-dimensional plasmonic superstructures as novel SERS labels will be synthesised and characterised at single-particle level and the choice of optimal SERS-active three-dimensional superstructures for use will be guided by empirical structure-activity correlations in combination with computer simulations. Tumour biomarkers for breast cancer will be employed as the model target for establishing the detection platform in a portable configuration for point-of-care diagnostics.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE200100186
Funder
Australian Research Council
Funding Amount
$233,000.00
Summary
The 3D Nanofabrication Facility. This project aims to breach the gap between meso, micro and nanoscale manufacturing by means of a novel 3D printing technique with nanometric resolution. This project expects to generate new knowledge in the technologies to fabricate complex structures with freedom of design from the meso to the nanoscale, currently not possible in Australia, by using the innovative integration of this technique within a well establish nanofabrication facility. Expected outcomes ....The 3D Nanofabrication Facility. This project aims to breach the gap between meso, micro and nanoscale manufacturing by means of a novel 3D printing technique with nanometric resolution. This project expects to generate new knowledge in the technologies to fabricate complex structures with freedom of design from the meso to the nanoscale, currently not possible in Australia, by using the innovative integration of this technique within a well establish nanofabrication facility. Expected outcomes of this project include new discoveries in fields such as nanotechnology, photonics, robotics, metamaterials, biosurface engineering or biotechnology. This should provide significant benefits, such as placing Australia in the leadership of nanotechnology and additive manufacturing.Read moreRead less
The development of novel and tunable metamaterials. Metamaterials are designed materials with properties that cannot be found in nature. This project uses a new disruptive design that allows broadband metamaterials to be made using mass production techniques. The design opens up a range of new applications in environmental and medical sensing, improved security screening and active devices.