Control Of SNARE-mediated Granule Fusion In Mast Cells
Funder
National Health and Medical Research Council
Funding Amount
$196,527.00
Summary
Asthma is an allergic disease affecting two million Australians. A major player in asthma is the mast cell which releases histamine when the cell is stimulated by antigen. The process by which histamine is released involves fusion of cytoplasmic granules containing the histamine with the cell surface membrane. The mechanism of this fusion process appears to be different in mast cells compared with other cells studied, raising the possibility that release of histamine, and hence the acute allergi ....Asthma is an allergic disease affecting two million Australians. A major player in asthma is the mast cell which releases histamine when the cell is stimulated by antigen. The process by which histamine is released involves fusion of cytoplasmic granules containing the histamine with the cell surface membrane. The mechanism of this fusion process appears to be different in mast cells compared with other cells studied, raising the possibility that release of histamine, and hence the acute allergic response, could be controlled if more were understood about the fusion process. This project aims to define the mechanism by which granules dock and then fuse with the cell surface. These are the two apects most likely to be unique in mast cells.Read moreRead less
Drinking Patterns, Gender And Social Roles In Alcohol Problems In Victoria, In An International Comparative Context
Funder
National Health and Medical Research Council
Funding Amount
$342,239.00
Summary
The varied impacts of drinking in the family and other gendered relations are an important and understudied aspect of alcohol studies, with general social and policy implications. The proposed research will make an important contribution to developing quantitative research in this area in Australia. The project uses concepts and measures which are novel in an Australian environment, and the international comparative aspect of the project, with comparable questionnaires in a wide diversity of soc ....The varied impacts of drinking in the family and other gendered relations are an important and understudied aspect of alcohol studies, with general social and policy implications. The proposed research will make an important contribution to developing quantitative research in this area in Australia. The project uses concepts and measures which are novel in an Australian environment, and the international comparative aspect of the project, with comparable questionnaires in a wide diversity of societies, is novel and innovative for the alcohol research field in general. Measures of social problems from drinking, and particularly and family and relationship, developed in analysing the study material will be made more broadly available for use in future studies, raising the possibility that the study may serve as a first measurement point for future data-series over time.Read moreRead less
Effects Of Lead And Socio-cultural Factors On Cognition And Behaviour Of Children In Port Pirie And Broken Hill
Funder
National Health and Medical Research Council
Funding Amount
$394,825.00
Summary
The effect of lead on children's 'intelligence' is controversial. Poorer IQ scores in children with higher exposure to lead, have been found reasonably consistently, - but there is disagreement on whether lead exposure is simply a common ASSOCIATE of poor IQ, or whether it actually CAUSES deficits. In 1994, the NHMRC prudently recommended a graded series of interventions to be implemented, depending on the proprtion of children in the community with blood lead concentrations in specific categori ....The effect of lead on children's 'intelligence' is controversial. Poorer IQ scores in children with higher exposure to lead, have been found reasonably consistently, - but there is disagreement on whether lead exposure is simply a common ASSOCIATE of poor IQ, or whether it actually CAUSES deficits. In 1994, the NHMRC prudently recommended a graded series of interventions to be implemented, depending on the proprtion of children in the community with blood lead concentrations in specific categories above 10 ug lead -100 ml of blood. The choice of this figure (10 ug-dl) was more pragmatic than scientific; there being very little data on the health effects of exposures below 10 ug-dl available at that time. A recent analysis of pooled data from past studies has now suggested there may be very large effects on child IQ at blood lead concentration BELOW 10 ug-dl. Health authorities will soon be lobbied intensely to spend vast sums on new lead abatement programs. Cities like Port Pirie and Broken Hill (where cooperative programs have achieved such significant reductions in lead exposure that a high percentage of their children now have blood lead levels below 10 ug-dl), will be forced to examine expensive options to avoid closure of the industries which provide their economic backbones, if this analysis proves to be correct. Our proposal argues that before committing to new and costly abatement programs, there is an urgent need to augment our evidence-base by conducting a new study ofchildren with lead exposures below 10 ug-dl, using more modern measures of intelligence. The study will pay closer attention to some of the socio-cultural and inherited determinants of child IQ which may have confounded the lead-IQ association in past studies, and will supplement IQ assessments (which are now considered to derive from a very old and narrow view of intelligence) with new tools for measuring 'intelligence' that may be less socio-culturally dependent.Read moreRead less
Living In A Rural Community: A Longitudinal Study Of The Course And Outcome Of Mental Health And Wellbeing.
Funder
National Health and Medical Research Council
Funding Amount
$841,947.00
Summary
This unique rural Australian study will investigate individual, family and community factors associated with the mental health and wellbeing of residents in rural communities of New South Wales. It aims to identify factors that may maintain or promote mental health, thereby investigating the potential protective effect of community factors, as well as more proximal social factors (such as family-household attributes and responses) on dimensions of mental health and wellbeing among rural people.
Changing Heat: Direct Impacts Of Temperature On Health And Productivity - Current Risks And Climate Change Projections
Funder
National Health and Medical Research Council
Funding Amount
$277,915.00
Summary
We know that heatwaves kill people - some 50,000 died in the 2003 European heatwave - but little is known of the details. This project will discover those details, in three important dimensions: WHO is at risk, and where do they live; HOW are people at risk, e.g. from kidney failure; and just WHAT is it about heat that is most dangerous? We will then build mathematical models of the future risks, and explore what public health measures will best protect Australians in a warming climate.
Cross-Sectional And Longitudinal Evaluation Of Childhood Anxiety And Depression: Pathways, Risk Factors And Prevention
Funder
National Health and Medical Research Council
Funding Amount
$333,055.00
Summary
Anxiety and depression are the most common forms of psychological distress affecting Australian children today. These disorders are seriously disabling and continuous across time. Therefore, it is very important to understand more about the onset and course of these disorders, and about factors which influence these disorders in either a positive or negative manner. There are three major goals for the current project. The first is to further our understanding of the development, maintenance, and ....Anxiety and depression are the most common forms of psychological distress affecting Australian children today. These disorders are seriously disabling and continuous across time. Therefore, it is very important to understand more about the onset and course of these disorders, and about factors which influence these disorders in either a positive or negative manner. There are three major goals for the current project. The first is to further our understanding of the development, maintenance, and amelioration of anxiety and depression in a child and youth population. The second is to understand the relationship between these two disorders in children and youth. The third is to use the acquired information to assist in the identification of optimal ages for preventive interventions, and to aid in the matching of interventions to the specific needs and vulnerabilities of children versus adolescents. This project aims to meet these goals through implementation of a controlled prevention trial. The aims fo the research are: 1. To examine the relationship between symptoms of anxiety and depresison in Australian children and youth 2. To gain valuable clinical information regarding the assessment and prevention of these disorders 3. To understand the risk and protective factors associated with these disorders, and the impact of these factors over time 4. To implement and evaluate a school-based prevention program The expected outcomes of the research are: 1. To acquire valuable information related to the onset and course of anxiety and depression in children and youth, and their associated risk and protective factors 2. To further development of more timely and targeted interventions for the prevention of anxiety and depression 4. To enhance the emotional resilience of participating children and prevent the onset of anxiety and depression 5. To promote Australian research by publishing the results of the project within the international research literatureRead moreRead less
Living In A Rural Community:determinants And Consequences Of Mental Health And Wellbeing.
Funder
National Health and Medical Research Council
Funding Amount
$729,415.00
Summary
Th e proposed study will investigate individual, family and community factors associated with the mental health and wellbeing of residents in rural communties of NSW. It will also examine rural residents' perceptions of their mental health needs and their access and utilisation of health services. The study will be conducted in 3 rural Area Health Services in NSW (Greater Western,Hunter New England and North Coast) comprising 70% of the rural population of NSW. These health regions encompass rur ....Th e proposed study will investigate individual, family and community factors associated with the mental health and wellbeing of residents in rural communties of NSW. It will also examine rural residents' perceptions of their mental health needs and their access and utilisation of health services. The study will be conducted in 3 rural Area Health Services in NSW (Greater Western,Hunter New England and North Coast) comprising 70% of the rural population of NSW. These health regions encompass rural, remote and coastal NSW. We aim to conduct the mail and telephone survey on adults residing in 4000 households across the 3 regions. Unique aspects of the study include: i) Examination of a diverse range of rural communities which will provide the opportunity to investigate the influence and interaction of specific community characteristics on mental health. These community factors will include social and economic factors, severity of rural environmental stress (eg drought), and the levels of access to health and other services. ii) Focus on the household and its members so as to examine the mental health needs of family groups in rural communities. This cross-sectional study will form the baseline for a longitudinal study investigating the changes experienced by rural families over time and the impact of such change on mental health outcomes.Read moreRead less
Safe Koori Kids: Community Based Approaches To Indigenous Injury Prevention
Funder
National Health and Medical Research Council
Funding Amount
$671,905.00
Summary
The study will involve the development of an intervention targeting Indigenous children, schools and families and schools in urban environments. Specifically, over a three year period, the proposed research aims to: explore the incidence and impact of intentional and unintentional injury in selected urban Indigenous communities in NSW and identify factors contributing to positive and negative consequences relating to injury; develop and evaluate initiatives in Indigenous communities aimed at inc ....The study will involve the development of an intervention targeting Indigenous children, schools and families and schools in urban environments. Specifically, over a three year period, the proposed research aims to: explore the incidence and impact of intentional and unintentional injury in selected urban Indigenous communities in NSW and identify factors contributing to positive and negative consequences relating to injury; develop and evaluate initiatives in Indigenous communities aimed at increasing resiliency in at-risk children, youth and families; and make recommendations for changes to policy and practice across a range of government portfolios and non-government organisations. Injury, which has received almost no research attention among Indigenous populations, is the leading cause of death, illness and disability for young Australians with the burden of injury for Indigenous Australians significantly higher than for the non-Indigenous population. Indigenous children and youth are over-represented in both intentional (eg. suicide, domestic violence and abuse, assaults and self-harm) and unintentional (eg. burns, road injury, falls and drowning) injury statistics. The complexity of injury to Indigenous people and its 'downstream' impact on families and communities has been documented in recent studies and reports. Although Indigenous children and youth are particularly vulnerable to the impact of injury, there have been few studies that have documented the incidence and impact of injury on Indigenous children or which have offered sustainable and culturally acceptable solutions to the problem of injury. The proposed research focuses on the development of effective, sustainable and culturally acceptable interventions for Indigenous children and youth based on an Indigenous perspective.Read moreRead less
Impact Of Parental Alcohol, Tobacco And Other Substance Use On Infant Development And Family Functioning
Funder
National Health and Medical Research Council
Funding Amount
$1,996,525.00
Summary
The current study will be the first large-scale Australian birth cohort study to comprehensively examine the effects of substance use in pregnant women and their partners during the prenatal period on infant developement and family functioning. Dramatically improved knowledge of these effects will provide evidence-based direction to the development of public health policy and community interventions that aim to improve the health and wellbeing of Australian children and families.