On the mechanism of boiling instability in microchannels. This project will enable designers to create highly efficient miniaturised devices based on the boiling of fluids such as water or organics. These devices include micro-power generation systems, coolers for computer chips and solar collectors, and micro-chemical process systems. Such devices provide environmental, safety and economic benefits.
Heat Transfer Characteristics of Biological Tissues with Nanoparticles. Heat transfer of laser-irradiated nanoparticles in biological tissues requires a basic knowledge of the unique strong resonance absorption properties and a fundamental understanding of the thermal and chemical conversions as a consequence of these heated nanoparticles. This project aims to investigate the extent of the non-equilibrium heating effects of heated nanoparticles on the destruction of biological tissues. Comprehen ....Heat Transfer Characteristics of Biological Tissues with Nanoparticles. Heat transfer of laser-irradiated nanoparticles in biological tissues requires a basic knowledge of the unique strong resonance absorption properties and a fundamental understanding of the thermal and chemical conversions as a consequence of these heated nanoparticles. This project aims to investigate the extent of the non-equilibrium heating effects of heated nanoparticles on the destruction of biological tissues. Comprehensive experimental studies and computational modelling to be performed are expected to significantly enhance the understanding of laser-induced heating phenomena of embedded nanoparticles in biological tissues and the prediction of the level of destruction that can be experienced by these heated nanoparticles.Read moreRead less
The Development of a Hybrid Energy Simulation Model for Masonry Enclosures. This project aims to develop and validate a hybrid energy simulation model for assessing the thermal performance of masonry enclosures. The model will combine the zonal and computational fluid dynamics modelling techniques into a fully integrated computational tool. Once validated, the proposed model will be employed to evaluate the thermal performance of a wide range of wall designs taking into account the Australian cl ....The Development of a Hybrid Energy Simulation Model for Masonry Enclosures. This project aims to develop and validate a hybrid energy simulation model for assessing the thermal performance of masonry enclosures. The model will combine the zonal and computational fluid dynamics modelling techniques into a fully integrated computational tool. Once validated, the proposed model will be employed to evaluate the thermal performance of a wide range of wall designs taking into account the Australian climatic conditions, construction practices and typical residential developments. The results will be then employed to modify and refine the existing wall designs and develop optimum masonry walling system(s) that are well suited for the Australian climatic conditions.Read moreRead less
Experimental Modelling of Masonry Buildings' Thermal Performance. Mathematical modelling of the thermal performance of buildings has been identified as one of the key technologies necessary for designing energy-efficient buildings. The aim of this project is to develop an experimental model of the thermal response of typical masonry enclosures by establishing relationships between input and output measurements from several full-scale test houses rather than relying on conservation principles. On ....Experimental Modelling of Masonry Buildings' Thermal Performance. Mathematical modelling of the thermal performance of buildings has been identified as one of the key technologies necessary for designing energy-efficient buildings. The aim of this project is to develop an experimental model of the thermal response of typical masonry enclosures by establishing relationships between input and output measurements from several full-scale test houses rather than relying on conservation principles. Once validated, the proposed model will be employed to evaluate the thermal performance of a wide range of walling systems. This should lead to an improved understanding of mechanisms influencing the thermal behaviour of masonry enclosures under Australian climatic conditions.Read moreRead less
Smart Utilisation of Thermal Mass in Masonry Buildings. This study will help determine the effectiveness of a range of novel technologies for smart utilisation of thermal mass in masonry buildings. The ultimate goal is to improve the thermal performance of such constructions. The project focuses on the National Research Priority 3 because of the novel and advanced technological nature of the proposed research. The project has also a significant potential in contributing to the Federal Government ....Smart Utilisation of Thermal Mass in Masonry Buildings. This study will help determine the effectiveness of a range of novel technologies for smart utilisation of thermal mass in masonry buildings. The ultimate goal is to improve the thermal performance of such constructions. The project focuses on the National Research Priority 3 because of the novel and advanced technological nature of the proposed research. The project has also a significant potential in contributing to the Federal Government's effort in the Research Priority 1 because achieving better thermal efficiency in buildings will undoubtedly help to minimise electricity usage leading to a reduction in CO2 emissions.Read moreRead less
Development and application of a virtue experimental blast furnace. This project aims to develop a virtual experimental blast furnace based on advanced discrete particle simulation technique. It is intended that the model furnace will be used to study the flow and thermochemical behaviour in iron making, quantify the effects of key variables related to raw material and operational conditions, and formulate strategies for optimum process design and control under different conditions. The findings ....Development and application of a virtue experimental blast furnace. This project aims to develop a virtual experimental blast furnace based on advanced discrete particle simulation technique. It is intended that the model furnace will be used to study the flow and thermochemical behaviour in iron making, quantify the effects of key variables related to raw material and operational conditions, and formulate strategies for optimum process design and control under different conditions. The findings aim to be very useful to comprehensively assess the performance of Australian minerals in iron making, improve the energy efficiency and reduce carbon dioxide emission in the steel industry, and enhance the competitiveness of the Australian economy.Read moreRead less
Yield improvement in large-scale bubble column fermenters. For companies operating in the global marketplace, yield differences of a few percent can be critically important. Improving yeast fermentation yield requires major advances in modelling the bubble size distribution and how this impacts micro- and macro-scale mixing. Model-based knowledge transfer via full-scale plant trials is a key outcome.
Design and Optimisation of Novel Enthalpy Heat Exchangers. This project deals with the thermal design and optimisation of a novel type of latent energy heat exchanger. This new heat exchanger overcomes the practical implementation problems of previous latent energy heat exchangers such as heat-wheels. The main application of this innovative heat exchanger will be to improve the capacity and efficiency of air conditioning systems. As the new heat exchanger is very compact it will be ideally sui ....Design and Optimisation of Novel Enthalpy Heat Exchangers. This project deals with the thermal design and optimisation of a novel type of latent energy heat exchanger. This new heat exchanger overcomes the practical implementation problems of previous latent energy heat exchangers such as heat-wheels. The main application of this innovative heat exchanger will be to improve the capacity and efficiency of air conditioning systems. As the new heat exchanger is very compact it will be ideally suited for integration with air conditioning coils. Existing latent heat wheels are very bulky and are difficult to integrate into standard air conditioner installations.Read moreRead less
Solving Delivery Of Gene Therapy For Control Of Human Immunodeficiency Virus Infection
Funder
National Health and Medical Research Council
Funding Amount
$765,439.00
Summary
Antiretroviral therapy free control of Human Immunodeficiency Virus (HIV) infection requires control of the viral reservoir. We have a unique approach, aimed at enforcing HIV latency by targeting highly conserved regions in the viral promoter. These constructs completely silence viral transcription for long periods of time. We intend to develop & assess vectors that are specifically targeted to the reservoir and which can enforce viral latency despite immune activation or viral variation.
Design of high performance heat sink composites. Heat sink composites are advanced materials that have the very substantial but widely untapped potential to reduce Society's energy consumption by means of utilizing waste energy or through energy-efficient temperature control. This Project uses computational analysis and parallel experimentation to design optimum heat-sink composites for highly energy-efficient temperature control of chemical batteries or electronic components as well as the mean ....Design of high performance heat sink composites. Heat sink composites are advanced materials that have the very substantial but widely untapped potential to reduce Society's energy consumption by means of utilizing waste energy or through energy-efficient temperature control. This Project uses computational analysis and parallel experimentation to design optimum heat-sink composites for highly energy-efficient temperature control of chemical batteries or electronic components as well as the means for the efficient heating/cooling of buildings. The outcomes of the project will lay the scientific foundation for the industrial scale development of advanced heat sinks that will lower energy costs and decrease climate changing emissions. This represents a new market for Australian industry.Read moreRead less